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datasets available to search
ShareScore release 0.9.0
Dataset results
316 results for “Cognitive aging”
Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway
ClinicalTrials.gov study NCT04200911. IPD Sharing: YES. Countries: 1. Publications: 1.
Maintaining Cognitive Health in Aging Veterans
ClinicalTrials.gov study NCT02023944. IPD Sharing: NO. Countries: 1. Publications: 14.
Aging and Cognitive Health Evaluation in Elders (ACHIEVE)
ClinicalTrials.gov study NCT03243422. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Leukotriene A4 hydrolase inhibition improves age related cognitive decline via modulation of synaptic function (Part 2/2)
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DNA methylation manipulation of memory genes is involved in sevoflurane induced cognitive impairments in aged rats
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Data from: Surgery impairs glymphatic activity and cognitive function in aged mice
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Age-specific activation patterns and inter-subject similarity during verbal working-memory maintenance and Cognitive Reserve
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Data for: General cognitive performance declines with female age and is negatively related to fledging success in a wild bird
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Leukotriene A4 hydrolase inhibition improves age related cognitive decline via modulation of synaptic function (Part 1/2)
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A neural implementation of cognitive reserve: insights from a longitudinal fMRI study of set-switching in aging
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Brief personalised rhythmic auditory stimulation facilitates cognitive and neural processing in ageing
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Age and atitude: How longevity influences cognitive biases in honeybee workers
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Data from: Sleep, inflammation, and cognitive behavior of aged wild-type mice subjected to diffuse brain injury and aged 3xTg-AD mice as a model of Alzheimer’s disease
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Data from: Cognition at age 70: life course predictors and associations with brain pathologies
Objective: To investigate predictors of performance on a range of cognitive measures including the Preclinical Alzheimer Cognitive Composite (PACC) and test for associations between cognition and dementia biomarkers in Insight 46, a sub-study of the MRC National Survey of Health and Development. Methods: 502 individuals born in the same week in 1946 underwent cognitive assessment at age 69-71 years, including an adapted version of the PACC and a test of non-verbal reasoning. Performance was characterised with respect to sex, childhood cognitive ability, education and socioeconomic position (SEP). In a sub-sample of 406 cognitively-normal participants, associations were investigated between cognition and β-amyloid (Aβ) positivity (determined from Aβ-PET imaging), whole brain volumes, white matter hyperintensity volumes (WMHV), and APOE-ε4. Results: Childhood cognitive ability was strongly associated with cognitive scores including the PACC more than 60 years later, and there were independent effects of education and SEP. Sex differences were observed on every PACC sub-test. In cognitively-normal participants, Aβ-positivity and WMHV were independently associated with lower PACC scores, and Aβ-positivity was associated with poorer non-verbal reasoning. Aβ-positivity and WMHV were not associated with sex, childhood cognitive ability, education or SEP. Normative data for 339 cognitively-normal Aβ-negative participants are provided. Conclusions: This study adds to emerging evidence that subtle cognitive differences associated with Aβ deposition are detectable in older adults, at an age when dementia prevalence is very low. The independent associations of childhood cognitive ability, education and SEP with cognitive performance aged 70 have implications for interpretation of cognitive data in later life.
Data from: Circulating cortisol and cognitive and structural brain measures in a middle-aged cohort: the Framingham Heart Study
Objective: To assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged adults without dementia. Methods: We evaluated dementia-free Framingham Study (Generation 3) participants (mean age 48.5 years; 46.8% men), who underwent cognitive testing for memory, abstract reasoning, visual perception, attention, and executive function (n= 2231), and brain MRI (n=2018) to assess total white matter, lobar gray matter, and white matter hyperintensity volumes and fractional anisotropy (FA) measures. We used linear and logistic regression to assess the relations of cortisol (categorized in tertiles, with the middle tertile as referent) to measures of cognition, MRI volumes, presence of covert brain infarcts (CBI) and cerebral microbleeds (CMB), and voxel-based microstructural white matter integrity and gray matter density, adjusting for age, sex, APOE and vascular risk factors. Results: Higher cortisol (highest tertile vs. middle tertile) was associated with worse memory and visual perception, as well as lower total cerebral brain, occipital and frontal lobar gray matter volumes. Higher cortisol was associated with multiple areas of microstructural changes (decreased regional FA), especially in the splenium of corpus callosum and the posterior corona radiata. The association of cortisol with total cerebral brain volume varied by sex (p interaction=0.048); higher cortisol was inversely associated with cerebral brain volume in women [p=0.001] but not in men [p=0.717]). There was no effect modification by the apoE4 genotype of the relations of cortisol and cognition or imaging traits. Conclusions: Higher serum cortisol was associated with lower brain volumes and impaired memory in asymptomatic younger to middle-aged adults, with the association being evident particularly in women.
Frequency of biologically-defined AD in relation to age, sex, APOEε4 and cognitive impairment in a prospective cohort study
<p><b>Objective:</b> <span> To assess the frequency of biologically-defined Alzheimer's disease (AD) in relation to age, sex and <i>APOEε4</i>, as well as rates of discordance between clinically- and biologically defined AD. </span></p> <p><b>Methods:</b> <span>We assessed cognitively unimpaired (CU) elderly (n=166), amnestic MCI (n=77) and probable AD dementia (n=62) subjects who underwent evaluation by dementia specialists and neuropsychologists in addition to amyloi</span>d-PET with [<sup>18</sup>F]AZD4694<span> and tau-PET with [<sup>18</sup>F]MK6240. Individuals were grouped according to their AD biomarker profile. Positive predictive value for biologically-defined AD was assessed in relation to clinical diagnosis. Frequency of AD biomarker profiles were assessed using logistic regressions with odds ratios and 95% CIs.</span></p> <p><b>Results:</b> <span>The clinical diagnosis of probable AD dementia demonstrated good agreement with biologically-defined AD (positive predictive value: 85.2%). 7.88% of CU elderly subjects were positive for both amyloid-PET and tau-PET. Frequency of biologically-defined AD increased with age (OR: 1.14; p<0.0001) and frequency of <i>APOEε4</i> allele carriers (Single <i>ε4: </i>OR: 3.82; <i>p</i><0.0001; Double <i>ε4: </i>OR: 17.55, <i>p</i><0.0001). </span></p> <p><b>Discussion:</b> While we observed <span>strong, but not complete, agreement between clinically-defined "probable AD" dementia and biomarker positivity for both amyloid</span>-β<span> and tau, we also observed that biologically-defined AD was not rare in CU elderly. A</span>bnormal tau-PET was almost exclusively observed in individuals with abnormal amyloid-PET. <span>Our results highlight that even in tertiary care memory clinics, detailed evaluation by dementia specialists systematically underestimates the frequency of biologically-defined AD and related entities. </span></p>
Data from: General perceptual-cognitive abilities: age and position in soccer
Various studies suggest the importance of sport-specific cognitive and perceptual abilities in soccer. However, the role of general perceptual-cognitive abilities and the relation of age respective to position have not been clarified for soccer in detail. Therefore, it was the objective of the present study to determine the relation of age and position to general perceptual-cognitive abilities. 178 highly talented male soccer players (mean age 16.2, age range 10 to 33 years) were involved. The participants performed computer-based sustained attention and anticipation (using Vienna Test System) tests. 139 subjects (mean age 16.6) took part in visual and acoustic reaction tests (using Talent Diagnostic System). The soccer players, subdivided into age and position groups, were recruited from a youth academy of a professional soccer club and played at the highest and 2nd highest national soccer competition for their age. Group differences were tested using analysis of variance. Correlations were analyzed for age and abilities. Significant correlations and group differences were found for age and sustained attention tasks. Significant differences for position groups were observed with regard to acoustic reaction time (ART). Further, we found statistical tendencies for group differences regarding the visual reaction time (VRT), indicating that midfielders outperform defenders and strikers in simple reaction tasks. Improved skills in sustained attention tasks resulted for defenders, who worked faster and more precisely in figural tasks. Regarding general anticipation tasks differences were not found. No group differences were found in basic anticipation tasks. Our study indicates that additional research is needed to further clarify the development of general perceptual-cognitive abilities and position-specific differences in the above abilities of highly talented soccer players.
Initial status and change in cognitive function mediate the association between academic education and physical activity in adults over 50 years of age
<p>The scripts for data management (i.e., from raw data to data used in the analyses) and for the models tested in the paper titled "Initial status and change in cognitive function mediate the association between academic education and physical activity in adults over 50 years of age".</p> <p>“SHARE_Data_merge_w8.R” --> merges the data between the 8 waves of measurement.</p> <p>“SHARE_computingVars_w8.R” --> computes the variables used in the abovementionned study.</p> <p>“Growth_curve_models.R” --> contains the statistical models tested in the abovementionned study.</p>
Cognitive Health in Ageing Register: Investigational, Observational and Trial Studies in Dementia Research: Prospective Readiness Cohort Study
ClinicalTrials.gov study NCT02114372. IPD Sharing: Not stated. Countries: 1. Publications: 2.
An Observational Study Using Multimodal Sensors to Measure Cognitive Health in Adults and Distinguish Mild Cognitive Impairment From Normal Aging
ClinicalTrials.gov study NCT05058950. IPD Sharing: YES. Countries: 1. Publications: 1.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.