Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,304
datasets available to search
ShareScore release 0.9.0
Dataset results
1,304 results for “Cognitive impairments”
PAK3 downregulation induces cognitive impairment following cranial irradiation
<p>Cranial irradiation is used for prophylactic brain radiotherapy as well as treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed that mice exposed to cranial irradiation exhibited cognitive dysfunction, including altered spontaneous behavior, decreased spatial memory, and reduced novel object recognition. Analysis of actin cytoskeleton revealed that ionizing radiation (IR) disrupted the filamentous/globular actin (F/G-actin) ratio and downregulated the actin turnover signaling pathway p21-activated kinase 3 (PAK3)-LIM kinase 1 (LIMK1)-cofilin. Furthermore, we found that IR could upregulate microRNA-206-3p (miR-206-3p) targeting PAK3. As the inhibition of miR-206-3p through antagonist (antagomiR), IR-induced disruption of PAK3 signaling is restored. In addition, intranasal administration of antagomiR-206-3p recovered IR-induced cognitive impairment in mice. Our results suggest that cranial irradiation-induced cognitive impairment could be ameliorated by regulating PAK3 through antagomiR-206-3p, thereby affording a promising strategy for protecting cognitive function during cranial irradiation, and promoting quality of life in patients with radiation therapy.</p>
[Supplementary Material] Personalised Route Training for People with Cognitive Impairments through Co-Creation
<p>Supplementary material for the paper ' Paving the Way: Personalised Route Training for People with Cognitive Impairments through Co-Creation' submitted to MUC 2024.</p>
Database on chemotherapy-induced cognitive impairment and its long-term development in patients with breast cancer - results from the observational CICARO Study
<p>Raw data and edited data on the observational CICARO-study on chemotherapy-induced cognitive impairment and its long-term development in patients with breast cancer</p>
Florbetaben (BAY94-9172) PET (Positron Emission Tomography) Imaging in MCI (Mild Cognitive Impairment) Patients
ClinicalTrials.gov study NCT01138111. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Program of Intensive Support in Emergency Departments for Care Partners of Cognitively Impaired Patients
ClinicalTrials.gov study NCT03325608. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease
ClinicalTrials.gov study NCT02380573. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders
ClinicalTrials.gov study NCT01333098. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study to Evaluate the Effects of Basmisanil in Participants With Cognitive Impairment Associated With Schizophrenia (CIAS) Treated With Antipsychotics
ClinicalTrials.gov study NCT02953639. IPD Sharing: YES. Countries: 1. Publications: 0.
PRIMA Intervention for Adults With Mild Cognitive Impairment and Their Caregivers
ClinicalTrials.gov study NCT04515875. IPD Sharing: NO. Countries: 1. Publications: 21.
Phase II Study of the Efficacy of Peptide T in HIV-Positive Individuals With Cognitive Impairment.
ClinicalTrials.gov study NCT00000392. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Supportive Care for Cognitively Impaired Patients and Families
ClinicalTrials.gov study NCT03881579. IPD Sharing: YES. Countries: 1. Publications: 0.
Brain and Cognitive Changes After Reasoning Training in Individuals With Mild Cognitive Impairment
ClinicalTrials.gov study NCT02596906. IPD Sharing: NO. Countries: 1. Publications: 1.
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
ClinicalTrials.gov study NCT01044758. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer's Disease
ClinicalTrials.gov study NCT02503501. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assess the Prognostic Usefulness of Flutemetamol (18F) Injection for Identifying Subjects With Amnestic Mild Cognitive Impairment Who Will Convert to Clinically Probable Alzheimer's Disease
ClinicalTrials.gov study NCT01028053. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Pharmacology of p38 MAP Kinase Inhibitor, VX-745, in Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD
ClinicalTrials.gov study NCT02423200. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Photobiomodularion on Brain Connectivity and Cognitive Function in Cognitive Impairment
ClinicalTrials.gov study NCT07287527. IPD Sharing: NO. Countries: 1. Publications: 1.
Applying a Person-Centered Approach to Enhance Cognitive Training in Senior Living Community Residents With Mild Cognitive Impairment
ClinicalTrials.gov study NCT03292705. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Study of Intravenous Immunoglobulin in Amnestic Mild Cognitive Impairment
ClinicalTrials.gov study NCT01300728. IPD Sharing: Not stated. Countries: 1. Publications: 3.
BI 425809 in Patients With Cognitive Impairment Due to Alzheimer's Disease.
ClinicalTrials.gov study NCT02788513. IPD Sharing: Not stated. Countries: 14. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.