Find research datasets worth reusing

opencc-by-4.0Dec 2022View details →

Figure 1 in Detection of respiratory viruses and expression of inflammatory cytokines in patients with acute exacerbation chronic obstructive pulmonary disease in Mongolia China

Figure 1. Distribution of Viruses.

opencc-by-4.0Jul 2024View details →

Molecular Dynamics Simulation and Docking Studies Reveals Inhibition of NF-kB signaling as a Promising Therapeutic Drug Target for reduction in Cytokines Storms

The complexes of the top identified molecules with NF-kB-kB site, as well as all the designed molecules used in the screening process.

opencc-by-4.0Sep 2018View details →

qPCR cytokines upon treatment

Raw data (Ct values) of qPCR performed on zebrafish rag1+/+ (wt) and rag1-/- (mutant) intestines dissected 6 hours after i.p. injection with PBS, Vibrio anguillarum or Anisakis simplex extract.

Data for Marshall et al, "Microbial metabolism disrupts cytokine activity to impact host immune response"

Raw data for publication "Microbial metabolism disrupts cytokine activity to impact host immune response", Marshall EKP et al. The archive is organized into folders containing raw data pertaining to each figure.

Design of facilitated dissociation enables control over cytokine signaling duration - SMT raw data - ASneo2 - ASneo2 + Effector - intraFRET ASneo2

This dataset contains the raw data for the Single-molecule tracking data of the manuscript: "Design of facilitated dissociation enables control over cytokine signaling duration". Presicely, it contains the imaging data for ASneo2 stimulation before and after effector addition and the smFRET with double labeled ASneo2 (E4C_K211C)

Design of facilitated dissociation enables control over cytokine signaling duration - SMT raw data - neo2 - neo2 + Effector

This dataset contains the raw data for the Single-molecule tracking data of the manuscript: "Design of facilitated dissociation enables control over cytokine signaling duration". Presicely, it contains the imaging data for neo2 stimulation before and after effector addition.

Design of facilitated dissociation enables control over cytokine signaling duration - SMT raw data - unstimulated - calibration beads - long term tracking - labelled ligand

This dataset contains the raw data for the Single-molecule tracking data of the manuscript: "Design of facilitated dissociation enables control over cytokine signaling duration". Presicely, it contains the calibration beads for all imaging experiments, the long term tracking experiments, the experiments with labelled ligand and the unstimulated probes

opencc-zeroAug 2021View details →

Cytokine storms and pyroptosis are primarily responsible for the rapid death of mice infected with pseudorabies virus

Pseudorabies virus (PRV) , the causative agent of Aujeszky's disease (AD), is one of the most harmful pathogens to the pig industry. PRV can infect and kill a variety of mammals. Nevertheless, the underlying pathogenesis related to PRV is still unclear. This study aims to investigate the pathogenesis induced by PRV in a mouse model. The mice infected with the PRV-HLJ strain were developed severe clinical manifestations at 36 hour post-infection (hpi), and mortality occurred within 48-72 hpi. Hematoxylin-eosin staining and qRT-PCR methods were used to detect the pathological damage and expression of cytokines related to immune reaction in brain tissue, respectively. The cytokine storms caused by IFN-α, IFN-β, TNF-α, IL-1β, IL-6 and IL-18 were related to the histopathological changes induced by PRV. This pattern of cytokine secretion depicts an image of typical cytokine storms, characterized by dysregulated secretion of pro-inflammatory cytokines and imbalanced pro-inflammatory and anti-inflammatory responses. In addition, the pyroptosis pathway was also activated by PRV by elevating the expression levels of nod-like receptor protein 3, caspase-1, gasdermin-D and interleukin-1β/18. These findings provide a way for further understanding the molecular basis in PRV pathogenesis.

opencc-zeroOct 2021View details →

Relationships between immune gene expression and circulating cytokine levels in wild house mice

1. Quantitative PCR (qPCR) has been commonly used to measure gene expression in a number of research contexts, but the measured RNA concentrations do not always represent the concentrations of active proteins which they encode. This can be due to transcriptional regulation or post-translational modifications, or localisation of immune environments, as can occur during infection. However, in studies using free-living non-model species, such as in ecoimmunological research, qPCR may be the only available option to measure a parameter of interest, and so understanding the quantitative link between gene expression and associated effector protein levels is vital. 2. Here we use qPCR to measure concentrations of RNA from mesenteric lymph node (MLN) and spleen tissue, and multiplex ELISA of blood serum to measure circulating cytokine concentrations in a wild population of a model species, Mus musculus domesticus. 3. Few significant correlations were found between gene expression levels and circulating cytokines of the same immune genes or proteins, or related functional groups. Where significant correlations were observed, these were most frequently within the measured tissue (i.e. the expression levels of genes measured from spleen tissue were more likely to correlate with each other rather than with genes measured from MLN tissue, or with cytokine concentrations measured from blood). 4. Potential reasons for discrepancies between measures, including differences in decay rates and transcriptional regulation networks are discussed. We highlight the relative usefulness of different measures under different research questions, and consider what might be inferred from immune assays.

opencc-zeroDec 2022View details →

Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)

Background: Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. It's final neurological outcome determined from both primary and secondary injury process. Neuroinflammation is a key component of the secondary injury mechanisms with local and systemic consequences. A neuroprotective compound, ACTH4-10Pro8-Gly9-Pro10 also known as Semax has shown neuroprotective and anti-inflammatory properties. ACTH4-10Pro8-Gly9-Pro10 also has actively used in the treatment of brain ischemia without serious complication reported. Here we analyzed the effects of ACTH4-10Pro8-Gly9-Pro10 in regulating inflammatory cascade in SCI by looking at the expression of anti-inflammatory cytokine IL-4, IL-10, IL-13 in acute compression SCI. Method: We do laminectomy in Sprague Dawley rats at the second thoracic vertebrae. After laminectomy we expose the myelum and create mild SCI model with 20gr and severe SCI with 35gr aneurysm clips. ACTH4-10Pro8-Gly9-Pro10 was administered intranasally to the treatment group and 0,9% NaCl to the control group (placebo). Both group was remain alive and terminated at 3 and 6 hour. The preparations tissue sample were fixed in formalin and examined for immunohistochemistry. Quantitative measurement of anti-inflammatory cytokine (IL-4, IL-10, IL-13) was done in posterior horn with associated anti-monoclonal antibodies. Result: Rats with mild SCI that were given ACTH4-10Pro8-Gly9-Pro10 shown greater expression of IL-4, IL-10 and IL-13 at three hour post compression but only IL-10 and IL-13 elevated significantly at six hour. Rats with severe compression in ACTH4-10Pro8-Gly9-Pro10 group shown greater expression of IL-10, IL-13 at three hour and IL-4, IL-10 at six hour compared with the placebo group. Conclusion: Administration of ACTH4-10Pro8-Gly9-Pro10 intranasal can increase anti inflammatory cytokine expression at Sprague Dawley rat model with mild and severe SCI. Expression of anti inflammatory cytokine was greater in mild compression and early hour (3 hour). Further research needs to be done to determine optimal dose and the actual clinical outcome in vivo.

opencc-by-4.0Dec 2022View details →

Database review of studies on the impact of flavonoids released in nanoparticles on cytokine production.

This table contains the data extracted from the source of evidence to analyze the role of flavonoids encapsulated in nanoparticles in the regulation of pro-inflammatory cytokines.

opencc-zeroMar 2023View details →

Microglial cytokines mediate plasticity induced by 10 Hz repetitive magnetic stimulation

Microglia—the resident immune cells of the central nervous system—sense the activity of neurons and regulate physiological brain functions. They have been implicated in the pathology of brain diseases associated with alterations in neural excitability and plasticity. However, experimental and therapeutic approaches that modulate microglia function in a brain-region-specific manner have not been established. In this study, we tested for the effects of repetitive transcranial magnetic stimulation (rTMS), a clinically employed non-invasive brain stimulation technique, on microglia-mediated synaptic plasticity. 10 Hz electromagnetic stimulation triggered a release of plasticity-promoting cytokines from microglia in organotypic brain tissue cultures, while no changes in microglial morphology or microglia dynamics were observed. Indeed, substitution of tumor necrosis factor alpha (TNFα) and interleukin 6 (IL6) preserved synaptic plasticity induced by 10 Hz stimulation in the absence of microglia. Consistent with these findings, in vivo depletion of microglia abolished rTMS-induced changes in neurotransmission in the medial prefrontal cortex (mPFC) of anesthetized mice. We conclude that rTMS affects neural excitability and plasticity by modulating the release of cytokines from microglia.

closedIPD-NOFeb 2026View details →

Cytokine-induced Memory-like NK Cells in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

ClinicalTrials.gov study NCT01898793. IPD Sharing: NO. Countries: 1. Publications: 4.

controlledIPD-YESFeb 2026View details →

Cytokine Induced Killer (CIK) Cells In Leukemia Patients

ClinicalTrials.gov study NCT01186809. IPD Sharing: YES. Countries: 1. Publications: 4.

Cytokines in Papillon-Lefèvre Syndrome

ClinicalTrials.gov study NCT01116934. IPD Sharing: Not stated. Countries: 1. Publications: 5.

The Efficacy of Symbiotic on Cytokines

ClinicalTrials.gov study NCT01899677. IPD Sharing: Not stated. Countries: 1. Publications: 1.

A Pivotal Study Of SU011248 In The Treatment Of Patients With Cytokine-Refractory Metastatic Renal Cell Carcinoma.

ClinicalTrials.gov study NCT00077974. IPD Sharing: Not stated. Countries: 1. Publications: 4.

controlledIPD-YESFeb 2026View details →

Effect of IMMUNEPOTENT-CRP on Serum Pro-Inflammatory Cytokines in Mild to Moderate COVID-19

ClinicalTrials.gov study NCT06676709. IPD Sharing: YES. Countries: 1. Publications: 26.

Academic Stress and Proinflammatory Cytokines: Omega-3 Intervention

ClinicalTrials.gov study NCT00519779. IPD Sharing: Not stated. Countries: 1. Publications: 1.