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31
datasets available to search
ShareScore release 0.9.0
Dataset results
31 results for “D-serine”
A Study to Compare the Safety, Tolerability, and Pharmacokinetics of CTP-692 Versus D-serine in Healthy Volunteers
ClinicalTrials.gov study NCT03778320. IPD Sharing: NO. Countries: 1. Publications: 0.
D-SPARK: A Clinical Trial of D-Serine for Modifying Parkinson's Disease Progression
ClinicalTrials.gov study NCT07312110. IPD Sharing: YES. Countries: 1. Publications: 0.
Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy Volunteers
ClinicalTrials.gov study NCT07079930. IPD Sharing: Not stated. Countries: 1. Publications: 0.
High Dose D-Serine as Adjuvant Treatment for Recent Onset Schizophrenia
ClinicalTrials.gov study NCT01459029. IPD Sharing: Not stated. Countries: 1. Publications: 0.
D-serine AudRem: R33 Phase
ClinicalTrials.gov study NCT05046353. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
D-Serine Treatment For Tardive Dyskinesia
ClinicalTrials.gov study NCT01804920. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila
GEO Series GSE207799. Drosophila melanogaster. 8 samples. Type: Expression profiling by high throughput sequencing.
Expression data from brain tissue of Rattus norvegicus treated with D-Serine
GEO Series GSE10748. Rattus norvegicus. 24 samples. Type: Expression profiling by array.
Serum D-serine to total serine ratio and glycine levels as predictive biomarkers for cognitive dysfunction in frail elderly subjects
<p>Here we report (i) the raw data used to conduct the study analyses; (ii) a list of online-only supplementary tables.</p> <p>Abstract: Frailty is a common age-related clinical syndrome characterized by a decline in the function of multiple organ systems, increased vulnerability to stressors and huge socio-economic burden on healthcare systems. Despite recent research efforts, the physiopathological mechanisms concurring to determine frailty remain elusive and biomarkers able to predate its occurrence in the early stages are still lacking. Beyond its physical component, cognitive decline represents a crucial domain of frailty associated with higher risk of adverse health outcomes. Previous OMICS studies showed a range of metabolic abnormalities in frail compared to non-frail subjects, such as dysregulation in the blood levels of glutamate, carnitine, urea cycle and kidney markers, as well as of anti-oxidants and pro-inflammatory cytokines.</p> <p>Here, in a well-characterized cohort of elderly subjects encompassing the entire continuum from fitness to frailty, we measured by High Performance Liquid Chromatography (HPLC) a pool of serum amino acids including L-glutamate, L-aspartate, glycine and D-serine, as well as their precursors L-glutamine, L-asparagine and L-serine. These amino acids are known to orchestrate excitatory and inhibitory neurotransmission the brain, but also play a key role as intermediates of energy metabolism and are critically involved in liver, kidney, muscle and immune system functioning. To comprehensively assess frailty, we employed both the Edmonton Frail Scale (EFS), as a practical and quick tool to capture the multidimensionality of frailty, and the frailty phenotype, as a measure of physical function. We found that D-serine and D-/Total serine ratio were independent predictors of EFS but not of physical frailty. Furthermore, higher glycine levels and D-/Total serine correlated with worse cognition and depressive symptoms in the frail group. Taken together, these findings suggest that altered homeostasis of blood D-serine may represent a biochemical signature of frailty in the elderly, while increased serum glycine and D-/Total serine ratio could be specifically associated with cognitive decline and depression in frail older populations.</p>
D-Serine Monotherapy for Schizophrenia
ClinicalTrials.gov study NCT00215917. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of D-serine on gene expression in Neuro2a cells
GEO Series GSE268106. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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