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282 results for “Data Deficient”
Data from: Homoploid F1 hybrids and segmental allotetraploids of japonica and indica rice subspecies show similar and enhanced tolerance to N deficiency than parental lines
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Mass spectrometry data from: Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens
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Data from: Anemia and related nutrient deficiencies after Roux-en-Y gastric bypass surgery: a systematic review and meta-analysis
Objective: To obtain a pooled risk estimate on the long-term impact of anaemia and related nutritional deficiencies in patients receiving Roux-en-Y gastric bypass (RYGB) surgery. Design: Systematic review and meta-analysis. Data sources: MEDLINE, EMBASE and Cochrane databases were searched to identify English reports published before 16 May 2014. Eligibility criteria: Articles with case numbers >100, follow-up period >12 months, and complete data from both before and after surgery were selected. Outcomes of interest were changes in baseline measurements of proportion of patients with anaemia, by haemoglobin, haematocrit, ferritin, iron, vitamin B12 and folate levels. Data collection and analysis: Two reviewers independently reviewed data and selected six prospective and nine retrospective studies with a total of 5909 patients. A random effect model with inverse variance weighting was used to calculate summary estimates of outcomes at 6, 12, 24 and 36 months postoperatively. Results: Proportion of patients with anaemia was 12.2% at baseline, which, respectively, increased to 20.9% and 25.9% at 12 and 24 months follow-up, consistent with decreases in haemoglobin and haematocrit levels. Although the serum iron level did not change substantially after surgery, the frequency of patients with ferritin deficiency increased from 7.9% at baseline to 13.4% and 23.0% at 12 and 24 months, respectively, postoperation. Vitamin B12 deficiency increased from 2.3% at baseline to 6.5% at 12 months after surgery in those subjects receiving RYGB. There was no obvious increase in folate deficiency. Conclusions: RYGB surgery is associated with an increased risk of anaemia and deficiencies of iron and vitamin B12, but not folate. Ferritin is more sensitive when serum iron level is within normal range.
Data from: Diagnosis of crop secondary and micro-nutrient deficiencies in sub-Saharan Africa
Crop production in sub-Saharan Africa has numerous biotic and abiotic constraints, including nutrient deficiencies. Information on crop response to macronutrients is relatively abundant compared with secondary and micronutrients (SMN). Data from 1339 trial replicates of 280 field trials conducted from 2013 to 2016 in 11 countries were analyzed for the diagnosis of SMN deficiencies. The diagnostic data included relative yield response (RYR) and soil and foliar test results. The RYR to application of a combination of Mg, S, Zn, and B (Mg-S-Zn-B) relative to a comparable N-P-K treatment was a >5% increase for 35% of the legume blocks and 60% of the non-legume blocks. The frequencies of soil test Zn, Cu, and B being below their critical level were 28, 2 and 10% for eastern and southern Africa, respectively, and 55, 58 and 89% for western Africa, while low levels for other SMN were less frequent. The frequency of foliar results indicating low availability were 58% for Zn, 16% for S and less for other SMN. The r2 values for relationships between soil test, foliar test and RYR results were <0.035 with little complementarity except for soil test Zn and B with cassava (Manihot esculenta L. Crantz) RYR in Ghana, and foliar Zn with cereal RYR in Uganda. Positive RYR is powerful diagnostic information and indicative of good profit potential for well-targeted and well-specified SMN application. Geo-referenced RYR, soil analysis and foliar analysis results for diagnosis of SMN deficiencies in 11 countries of sub-Saharan Africa were generally not complementary.
Data from: Sex-dependent differences in central artery hemodynamics in normal and fibulin-5 deficient mice: implications for ageing
Mouse models provide unique opportunities to study vascular disease, but they demand increased experimental and computational resolution. We describe a workflow for combining in vivo and in vitro biomechanical data to build mouse-specific computational models of the central vasculature including regional variations in biaxial wall stiffness, thickness and perivascular support. These fluid–solid interaction models are informed by micro-computed tomography imaging and in vivo ultrasound and pressure measurements, and include mouse-specific inflow and outflow boundary conditions. Hence, the model can capture three-dimensional unsteady flows and pulse wave characteristics. The utility of this experimental–computational approach is illustrated by comparing central artery biomechanics in adult wild-type and fibulin-5 deficient mice, a model of early vascular ageing. Findings are also examined as a function of sex. Computational results compare well with measurements and data available in the literature and suggest that pulse wave velocity, a spatially integrated measure of arterial stiffness, does not reflect well the presence of regional differences in stiffening, particularly those manifested in male versus female mice. Modelling results are also useful for comparing quantities that are difficult to measure or infer experimentally, including local pulse pressures at the renal arteries and characteristics of the peripheral vascular bed that may differ with disease.
Supporting data set for: Sulfur-deficient edges as active sites for hydrogen evolution on MoS2
<p>Computed structures of the elementary steps of hydrogen evolution on MoS2 edges and basal plane, obtained with neutral supercells.</p><p>Naming convention: POSCAR-[system]-[number of H after Volmer step]-[reaction]-[state].</p>
Iodine deficiency data extraction sheet
<p><span>The contents of the Excel file reporting the studies assessing the prevalence of iodine deficiency and associated factors among school-age children in Ethiopia, 2023 are: <span>name of the authors, year of publication, study year, country, region, study design, study setting, quality of the paper, total population, iodine deficient population, prevalence of iodine deficiency, standard error of the prevalence and factors such as age, sex, goitrogenic food consumption, salt container used to store the iodized salt, salt adding time and maternal educational status and their derivatives.</span></span></p>
Metadata of the extracted data assessing iodine deficiency and associated factors among school-age children in Ethiopia, 2023.
<p>This is Meta-data of the extracted data assessing the prevalence of iodine deficiency and associated factors among school-age children in Ethiopia, 2023</p>
Translin facilitates RNA polymerase II dissociation and suppresses genome instability during RNase H2- and Dicer-deficiency (data files)
<p>The conserved nucleic acid binding protein Translin contributes to numerous facets of mammalian biology and genetic diseases. It was first identified as a binder of cancer-associated chromosomal translocation breakpoint junctions leading to the suggestion that it was involved in genetic recombination. With a paralogous partner protein, Trax, Translin has subsequently been found to form a hetero-octomeric RNase complex that drives some of its functions, including passenger strand removal in RNA interference (RNAi). The Translin-Trax complex also degrades the precursors to tumour suppressing microRNAs in cancers deficient for the RNase III Dicer. This oncogenic activity has resulted in the Translin-Trax complex being explored as a therapeutic target. Additionally, Translin and Trax have been implicated a wider range of biological function ranging from sleep regulation to telomere transcript control. Here we reveal a Trax- and RNAi-independent function for Translin in dissociating RNA polymerase II from its genomic template, with loss of Translin function resulting in increased transcription-associated recombination and elevated genome instability. This provides genetic insight into the longstanding question of how Translin might influence chromosomal rearrangements in human genetic diseases and provides important functional understanding of an oncological therapeutic target.</p>
Supplementary data for "Analysis of Non-21α-hydroxylase-deficiency Primary Adrenal Insufficiency in Childhood: Data from 113 Chinese Patients"
<p>Supplementary data for "Analysis of Non-21α-hydroxylase-deficiency Primary Adrenal Insufficiency in Childhood: Data from 113 Chinese Patients"</p> <p><strong>Supplementary Table 1 </strong>Causes of Primary Adrenal Insufficiency in Children</p> <p><strong>Supplementary Table 2</strong> Mutations Detected in Subjects with non-21-OHD CAH Inherited Causes of Childhood-Onset Primary Adrenal Insufficiency</p> <p><strong>Supplementary Table 3 </strong>Clinical findings in Subjects with Non-21-OHD Inherited Causes of Childhood-Onset Primary Adrenal Insufficiency</p> <p><strong>Supplementary Table 4 </strong>Population Frequencies of Common Variants in <em>STAR</em> or <em>MC2R</em></p>
Data set for the manuscript 'Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency'
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Microsatellite genotypes and associated data for: Tetrasporophyte bias coupled with heterozygote deficiency in Antarctic Plocamium sp. (Rhodophyta)
<p>Meiosis and syngamy generate an alternation between two ploidy stages, but the timing of these two processes varies widely across taxa, thereby generating life cycle diversity. One hypothesis suggests that life cycles with long-lived haploid stages are correlated with selfing, asexual reproduction, or both. Though mostly studied in angiosperms, selfing and asexual reproduction are often associated with marginal habitats. Yet, in haploid-diploid macroalgae, these two reproductive modes have subtle, but unique consequences whereby predictions from angiosperms may not apply. Along the western Antarctic Peninsula, there is a thriving macroalgal community, providing an opportunity to explore reproductive system variation in haploid-diploid macroalgae at high latitudes where endemism is common. <em>Plocamium </em>sp. is a widespread and abundant red macroalga found within this ecosystem. We sampled twelve sites during 2017 and 2018 field seasons and used ten microsatellite loci to describe the reproductive system. Overall genotypic richness and evenness were high, suggesting sexual reproduction. Eight sites were dominated by tetrasporophytes, but there was strong heterozygote deficiency, suggesting intergametophytic selfing. We found slight differences in the prevailing reproductive mode among sites, possibly due to local conditions (e.g., disturbance) that may contribute to site-specific variation. It remains to be determined whether high levels of selfing are characteristic of macroalgae more generally at high latitudes or due to the haploid-diploid life cycle. Further investigations of algal life cycles will likely reveal the processes underlying the maintenance of sexual reproduction more broadly across eukaryotes, but more studies of natural populations are required.</p>
Raw data of visual search parameters of individuals with normal trichromacy and colour vision deficiency
<p><strong><span>Background</span></strong><span>: Colour-related search tasks are common in many professional fields. The study investigated whether increasing chromatic saturation can enhance the visual performance of individuals with colour vision deficiency (CVD) in colour-related search tasks.</span></p> <p><strong><span>Methods</span></strong><span>: 10 normal trichromats (5M, 5F; Mean (SD) age: 23.1 (3.3) years) and 15 individuals with CVD [8 deutans and 7 protans identified by HRR plates] (14M, 1F; aged 28.6 (8.7) years) participated in this study. Four naturalistic sceneries of everyday tasks/ birds, animals, and flowers of 15 different colour combinations (1 pair of colours in each combination. e.g., 'brown/black' or 'red/green') were presented in 'low' saturation, 'original' (unaltered images) and 'high' saturation condition using the Psychopy program on a colour-calibrated monitor. On each trial, the subject was asked to identify a specific-coloured target. </span></p> <p><span><strong>Results</strong>: </span><span>Overall, the visual search performance index (expressed as product of accuracy and a reciprocal of reaction time (%correct*s<sup>-1</sup>) of the normal trichromats [Mean (SD):77.76% correct*s<sup>-1</sup> (16.32)] was significantly higher than CVD [45.71 % correct*s<sup>-1</sup> (18.95)] in the "original" test images (p = 0.001), but in individuals with CVD, there was no significant difference between 'original' [45.71 % correct*s<sup>-1</sup> (18.95)] and 'high' saturation condition ([47.43 % correct*s<sup>-1</sup> (20.07)]; p > 0.05). However, colour-wise, increased saturation showed improvements (≥ 10 %) in protans mainly for 'red' combinations with other colours such as white (i.e., 'red/white'), purple, orange, grey, green, brown, and black.</span></p> <p><strong><span>Conclusion</span></strong><span>:</span><span> The study suggests that increasing the saturation of certain colour combinations can potentially aid in the visual search performance of individuals with CVD. This knowledge will help in better counselling and management of the patients.</span></p>
Study to Re-assess and Re-confirm Data Previously Recorded About the Incidence and Severity of Acute Abdominal "Pancreatitis" Episodes in Lipoprotein Lipase Deficient (LPLD) Subjects Previously Enroll
ClinicalTrials.gov study NCT01448577. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Study to Collect Data to Build Artificial Intelligence Derived Algorithms for Estimating Risk of Iron Deficiency and Anaemia in African Children
ClinicalTrials.gov study NCT07186205. IPD Sharing: NO. Countries: 1. Publications: 4.
Raw data of visual search parameters of individuals with normal trichromacy and colour vision deficiency
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Data from: Diagnosis of crop secondary and micro-nutrient deficiencies in sub-Saharan Africa
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Data from: Sex-dependent differences in central artery hemodynamics in normal and fibulin-5 deficient mice: implications for ageing
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RNAseq data from: Medial prefrontal cortex samples of glutamate dehydrogenase-deficient mice, stress-exposed or -naive, and their Nestin-Cre+ controls
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Data from: Anemia and related nutrient deficiencies after Roux-en-Y gastric bypass surgery: a systematic review and meta-analysis
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.