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769 results for “Deprivation”
Example meshes for 'Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation'
<p>Example meshes for 'Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation'</p> <p>The meshes contain DTI. To read the mesh to FEniCS, see e.g., <a href="https://github.com/bzapf/braintransport/blob/24ba4e37a3d6fadb37c249ca7f717a7355f48f30/optimal_velocity/postprocess_phi.py#L12">here </a>.</p> <p>Find the simulation codes for the manuscript here:</p> <p><a href="https://github.com/bzapf/braintransport">https://github.com/bzapf/braintransport</a></p>
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of TAK-925 Study in Sleep-Deprived Healthy Adults
ClinicalTrials.gov study NCT03522506. IPD Sharing: YES. Countries: 1. Publications: 1.
Transient cognitive impacts of oxygen deprivation caused by catch-and-release angling
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Food deprivation exposes sex-specific trade-offs between stress tolerance and lifespan in the copepod Tigriopus californicus
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Exploratory analysis of sleep deprivation effects on gene expression and regional brain metabolism
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Sleep deprivation drives brain-wide changes in cholinergic pre-synapse abundance in Drosophila melanogaster
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Data from: Longitudinal effects of early psychosocial deprivation on macaque executive function: Evidence from computational modelling
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Flying on empty: Reduced mitochondrial function and flight capacity in food-deprived monarch butterflies
<p>Mitochondrial function is fundamental to organismal performance, health, and fitness – especially during energetically challenging events, such as migration. With this investigation, we evaluated mitochondrial sensitivity to ecologically relevant stressors. We focused on an iconic migrant, the North American monarch butterfly (Danaus plexippus), and examined the effects of two stressors: seven days of food deprivation, and infection by the protozoan parasite Ophryocystis elektroscirrha (known to reduce survival and flight performance). We measured whole-animal resting metabolic rate (RMR) and peak flight metabolic rate, and mitochondrial respiration of isolated mitochondria from the flight muscles. Food deprivation reduced mass-independent RMR and peak flight metabolic rate, whereas infection did not. Fed monarchs used mainly lipids in flight (respiratory quotient 0.73), but the respiratory quotient dropped in food-deprived individuals, possibly indicating switching to alternative energy sources, such as ketone bodies. Food deprivation decreased mitochondrial maximum oxygen consumption but not basal respiration, resulting in lower respiratory control ratio (RCR). Furthermore, food deprivation decreased mitochondrial complex III activity, but increased complex IV activity. Infection did not result in any changes in these mitochondrial variables. Mitochondrial maximum respiration rate correlated positively with mass-independent RMR and flight metabolic rate, suggesting a link between mitochondria and whole-animal performance. In conclusion, low food availability negatively affects mitochondrial function and flight performance, with potential implications for migration, fitness, and population dynamics. Although previous studies have reported poor flight performance in infected monarchs, we found no differences in physiological performance, suggesting that reduced flight capacity may be due to structural differences or low energy stores.</p>
Code and data for "Impact of Auditory Deprivation on Tennis Performance and Perceived Exertion"
<p>Written in R + RMarkdown. Using `renv` to manage dependencies. Run `renv::restore()` after loading the project to<br>obtain required libraries.</p> <p>Main contents description:</p> <p>- `auditory_deprivation.Rmd` the main analysis file<br>- `data/data ENG.xlsx` the main dataset</p>
Example MRI scans from sleep deprivation experiment
<p>As part of a pre-study in a sleep deprivation experiment, large amount of brain MRI scans were collected.<br> An example set is shared here. The scans were taken after being awake for approximately 3, 14, 27 and 35 hours. </p> <p>The primary goal is to help researchers with example data. For instance, image co-registration between repeated scans could be challenging, or co-registering volumes from various protocols, visualization, etc. </p> <p>The dataset is voluntarily shared and published by the subject (me) for any scientific and non-commercial use.</p>
Deprived Urban Areas in Nairobi
<p>Code and main results of the analysis in the deprived urban areas of Nairobi, Kenya through Earth Observation and machine learning techniques.</p>
Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation
<p>Neurotransmission is an energetically expensive process that underlies cognition. During intense electrical activity or dietary restrictions, glucose levels in the brain plummet, forcing neurons to utilize alternative fuels. However, the molecular mechanisms of neuronal metabolic plasticity remain poorly understood. Here, we demonstrate that glucose-deprived neurons activate the CREB and PGC1α transcriptional program that induces the expression of the mitochondrial deacetylase Sirtuin 3 (Sirt3) both <em>in vitro</em> and i<em>n vivo</em>. We show that Sirt3 localizes to axonal mitochondria and stimulates mitochondrial oxidative capacity in hippocampal nerve terminals. Sirt3 plays an essential role in sustaining synaptic transmission in the absence of glucose by powering the retrieval of synaptic vesicles after release. These results demonstrate that the transcriptional induction of Sirt3 ensures the metabolic plasticity of synaptic transmission.</p>
Sleep-like changes in neural processing emerge during sleep deprivation in early auditory cortex - Dataset
<p>Dataset summarizing for every State X Unit the auditory response features + the statistical models for all the different figures.</p> <p><br> Variables:</p> <p>corticosteroneRawData:the corticosterone measures in 12 animals across the five conditions described in the paper.</p> <p>statistics: statistical models for every figure</p> <p>isUnitValidForAnalysis: Logical vector with n units length describing which units were included in every analysis.</p> <p>resultsPerUnit: auditory response features per unit for all the different states/conditions described in the paper (Vigilant, Tired, NREM, REM, Q-Wakefulness during recovery sleep, movement-controlled Vigilant and Tired conditions).</p> <p>Each state is a struct with 496 entries (496 units). the different field in the struct are:</p> <p>- session: animal and session identifiers.</p> <p>- isContext: is Auditory Paradigm A (with 2,10,20,30,40 Hz Click Trains) or B (just 40 Hz click trains.</p> <p>- ch: recording channel/microwire # (1-16)</p> <p>- clus: cluster number in channel</p> <p>- clusType: is single-unit / multi-unit</p> <p>- spikeShape: the average spike waveform</p> <p>- baseFr: unit's baseline firing rate</p> <p>- baseFanoFactor: fano factor of each unit's baseline firing rate (not used in paper).</p> <p>- baseIsiCv: baseline ISI (inter-spike interval) CV (coefficient of variation), not used in paper</p> <p>- basePopCoupling: baseline population coupling values</p> <p>- clicks40Hz: 40Hz click responses</p> <p>- clicksAll: responses to all click trains (2,10,20,30,40 Hz)</p> <p>- offState: post-onset and off-state analysis.</p> <p>- clicksSim: simulated click response to different click rates based on the onset+post onset responses as in Supp. Fig. 6.</p> <p>- PostOnsetYoked: Surrogate post-onset response following spontaneous bursts as in Fig. 5A-C</p> <p>- drc: responses to Dynamic random chords used to get tuning.</p> <p> </p> <p> </p> <p> </p>
The duration effect of short-term monocular deprivation measured by binocular rivalry and binocular combination
<p>Full dataset and analysis script (Python) of the data presented in the paper "The duration effect of short-term monocular deprivation measured by binocular rivalry and binocular combination" by Prosper, Pasqualetti, Morrone & Lunghi (https://doi.org/10.1016/j.visres.2023.108278).</p> <p>Dataset and full description in README file.</p> <p>Analysis description in "analysis_notebook" file.</p>
Data for the paper Prey consumption does not restore hydration state but mitigates the energetic costs of water deprivation in an insectivorous lizard
<p>Morphological and physiological data for the paper untitled "Prey consumption does not restore hydration state but mitigates the energetic costs of water deprivation in an insectivorous lizard" published in Journal of Experimental Biology in 2023</p> <p>Additionnal data on statistical analysis and model summary</p>
Predicting school uptake of The Daily Mile in Northern Ireland- a data linkage study with School Census Data and Multiple Deprivation Measures
<p>The datasets for the research into the uptake of The Daily Mile in Northern Ireland- a data linkage study with School Census Data and Multiple Deprivation Measures. Questionnaires completed between 31st August 2022 and 16th December 2022. </p>
Clinical Trials of Adjuvant Androgen Deprivation in Localized Prostate Cancer
ClinicalTrials.gov study NCT02175212. IPD Sharing: Not stated. Countries: 1. Publications: 20.
Phase II Study of Dasatinib (BMS-354825) for Androgen-deprived Progressive Prostate Cancer
ClinicalTrials.gov study NCT00385580. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer
ClinicalTrials.gov study NCT00936390. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Efficacy and Safety of Pembrolizumab (MK-3475) Plus Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Pro
ClinicalTrials.gov study NCT04191096. IPD Sharing: YES. Countries: 29. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.