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41 results for “Deuterium”
Preparation of Deuterium-Labeled Armodafinil by Hydrogen–Deuterium Exchange and Its Application in Quantitative Analysis by LC-MS
<p>Armodafinil, the R enantiomer of modafinil, was approved in 2007 by the US Food and<br> Drug Administration as a wake-promoting agent for excessive sleepiness treatment. Due to its<br> abuse by students and athletes, there is a need of its quantification. Quantitative analysis by liquid<br> chromatography-mass spectrometry, however, though very common and sensitive, frequently cannot<br> be performed without isotopically labeled standards which usually have to be specially synthesized.<br> Here we reported our investigation on the preparation of deuterated standard of armodafinil based<br> on the simple and inexpensive hydrogen–deuterium exchange reaction at the carbon centers. The<br> obtained results clearly indicate the possibility of introduction of three deuterons into the armodafinil<br> molecule. The introduced deuterons do not undergo back exchange under neutral and acidic<br> conditions. Moreover, the deuterated and non-deuterated armodafinil isotopologues revealed coelution<br> during the chromatographic analysis. The ability to control the degree of deuteration using<br> different reaction conditions was determined. The proposed method of deuterated armodafinil<br> standard preparation is rapid, cost-efficient and may be successfully used in its quantitative analysis<br> by LC-MS.</p>
Synthesis of Tris[2‐(dimethylamino)ethyl]amine with Regiospecific Deuterium Labels
<p>Simple synthetic routes to regioselectively deuterated tris[2-(dimethylamino)ethyl]amine (Me6TREN) variants are described. Imine formation with formaldehyde-d2 from tris(2-aminoethyl)amine (TREN) and subsequent reductions with NaBD4 afforded N[CH2CH2N(CD3)2]3 or d18-Me6TREN in 79 % yield. A trisubstitution protocol from 2-bromo-N,N-dimethylacetamide and ammonium carbonate and subsequent reduction of the N(CH2CONMe2)3 intermediate by lithium aluminum deuteride has afforded N[CH2CD2N(CH3)2]3 or (d6-arm)-Me6TREN in three steps and 52 % overall yield. A similar protocol from 2-bromo-N,N-dimethyl-d2-acetamide, obtained in two steps from d4-acetic acid, with reduction of the N(CD2CONMe2)3 intermediate by lithium aluminum hydride has afforded N[CD2CH2N(CH3)2]3 or (d6-cap)-Me6TREN in four steps and 13 % overall yield from CD3COOD.</p>
Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength
<p>Raw 2H-NMR Data of deuterium content in tumor tissues. </p>
TES/Aura L3 Deuterium Oxide Monthly Gridded V006
TL3HDOM_6 is the Tropospheric Emission Spectrometer (TES)/Aura L3 Deuterium Oxide Monthly Gridded Version 6 data product. TES was an instrument aboard NASA's Aura satellite and was launched from California on July 15, 2004. Data collection for TES is complete. This product consisted of daily atmospheric temperature and volume mixing ratio (VMR) for the atmospheric species, which were provided at 2 degree latitude by 4 degree longitude spatial grids and at a subset of TES standard pressure levels. The TES Science Data Processing L3 subsystem interpolated the L2 atmospheric profiles collected in a Global Survey onto a global grid uniform in latitude and longitude to provide a 3-D representation of the distribution of atmospheric gasses. Daily and monthly averages of L2 profiles and browse images are available. The L3 standard data products were composed of L3 HDF-EOS grid data. A separate product file was produced for each different atmospheric species. TES obtained data in two basic observation modes: Limb or Nadir. The product file may have contained, in separate folders, limb data, nadir data, or both folders may have been present. Specific to L3 processing were the terms Daily and Monthly, which represented the approximate time coverage of the L3 products. However, the input data granules to the L3 process were completed Global Surveys; in other words a Global Survey were not split in relation to time when input to the L3 processes even if they exceed the usual understood meanings of a day or month. More specifically, Daily L3 products represented a single Global Survey (approximately 26 hours) and Monthly L3 products represented Global Surveys that were initiated within that calendar month. The data granules defined for L3 standard products were daily and monthly. Details of the format of this product can be found in the TES Data Products Specifications (DPS).
TES/Aura L2 Deuterium Oxide Lite Nadir V007
TL2HDOLN_7 is the Tropospheric Emission Spectrometer (TES)/Aura Level 2 Deuterium Oxide Lite Nadir Version 7 data product. TES was an instrument aboard NASA's Aura satellite and was launched from California on July 15, 2004. Data collection for TES is complete. TES Level 2 data contains retrieved species (or temperature) profiles at the observation targets and the estimated errors. The geolocation, quality, and other data (e.g., surface characteristics for nadir observations) were also provided. L2 modeled spectra were evaluated using radiative transfer modeling algorithms. The process, referred to as retrieval, compared observed spectra to the modeled spectra and iteratively updated the atmospheric parameters. L2 standard product files included information for one molecular species (or temperature) for an entire global survey or special observation run. A global survey consisted of a maximum of 16 consecutive orbits. A nadir sequence within the TES Global Survey was a fixed number of observations within an orbit for a Global Survey. Prior to April 24, 2005, it consisted of two low resolution scans over the same ground locations. After April 24, 2005, Global Survey data consisted of three low resolution scans. The Nadir standard product consisted of four files, where each file was composed of the Global Survey Nadir observations from one of four focal planes for a single orbit, i.e. 72 orbit sequences. The Global Survey Nadir observations only used a single set of filter mix. A Global Survey consisted of observations along 16 consecutive orbits at the start of a two day cycle, over which 3,200 retrievals were performed. Each observation was the input for retrievals of species volume mixing ratios (VMRs), temperature profiles, surface temperature and other data parameters with associated pressure levels, precision, total error, vertical resolution, total column density, and other diagnostic quantities. Each TES Level 2 standard product reported information in a swath format conforming to the HDF-EOS Aura File Format Guidelines. Each Swath object was bounded by the number of observations in a global survey and a predefined set of pressure levels representing slices through the atmosphere. Each standard product could have had a variable number of observations depending upon the Global Survey configuration and whether averaging is employed. Also, missing or bad retrievals were not reported. The organization of data within the Swath object was based on a superset of the Upper Atmosphere Research Satellite (UARS) pressure levels that was used to report concentrations of trace atmospheric gases. The reporting grid was the same pressure grid used for modeling. There were 67 reporting levels from 1211.53 hPa, which allowed for very high surface pressure conditions, to 0.1 hPa, about 65 km. In addition, the products reported values directly at the surface when possible or at the observed cloud top level. Thus in the Standard Product files each observation could potentially contain estimates for the concentration of a particular molecule at 67 different pressure levels within the atmosphere. However, for most retrieved profiles, the highest pressure levels were not observed due to a surface at lower pressure or cloud obscuration. For pressure levels corresponding to altitudes below the cloud top or surface, where measurements were not possible, a fill value was applied.To minimize the duplication of information between the individual species standard products, data fields common to each species (such as spacecraft coordinates, emissivity, and other data fields) have been collected into a separate standard product, termed the TES L2 Ancillary Data product (ESDT short name: TL2ANC). Users of this product should also obtain the Ancillary Data product.
TES/Aura L3 Deuterium Oxide Daily Gridded V006
TL3HDOD_6 is the Tropospheric Emission Spectrometer (TES)/Aura Level 3 (L3) 3 Deuterium Oxide Daily Gridded Version 6 data product. It consists of daily atmospheric temperature and volume mixing ratio (VMR) for the deuterium oxide atmospheric species, which are provided at 2 degree latitude by 4 degree longitude spatial grids and at a subset of TES standard pressure levels. TES was an instrument aboard NASA's Aura satellite and was launched from California on July 15, 2004. Data collection for TES is complete. The TES Science Data Processing L3 subsystem interpolated L2 atmospheric profiles collected in a Global Survey onto a global grid uniform in latitude and longitude to provide a 3-D representation of the distribution of atmospheric gasses. The L3 standard data products are composed of L3 HDF-EOS grid data. A separate product file was produced for each different atmospheric species. TES obtained data in two basic observation modes: Limb or Nadir; Nadir observations, which point directly to the surface of the Earth, are different from limb observations, which are pointed at various off-nadir angles into the atmosphere. The product file may contain, in separate folders, limb data, nadir data, or both folders may be present. Specific to L3 processing were the terms Daily and Monthly representing the approximate time coverage of the L3 products. However, the input data granules to the L3 process are complete Global Surveys; in other words a Global Survey was not split in relation to time when input to the L3 processes even if they exceed the usual understood meanings of a day or month. More specifically, Daily L3 products represented a single Global Survey (approximately 26 hours) and Monthly L3 products represent Global Surveys that are initiated within that calendar month. The data granules defined for L3 standard products were daily and monthly.
Repository: Deuterium and 37Chlorine Rich Fluids on the Surface of Mars: Evidence from the Enriched Basaltic Shergottite Northwest Africa 8657
<p>This repository contains three supplementary tables corresponding to the EPMA and nanoSIMS analytical data of apatite from the martian meteorite NWA 8657.</p> <p>Supplementary Table 1: EPMA result of apatite from NWA 8657 .</p> <p>Supplementary Table 2: Water content and hydrogen isotopes of apatite, merrillite, maskelynite, mesostasis, and pyroxene from NWA 8657.</p> <p>Supplementary Table 3: Cl content and Cl isotopes of apatite from NWA 8657.</p> <p> </p>
Deuterium Metabolic Imaging repeatability dataset, Aarhus 2023
<p>### BACKGROUND</p> <p>Manuscript title: ‘Repeatability of deuterium metabolic imaging of healthy volunteers at 3T’<br> Authors: Nikolaj Bøgh, Michael Vaeggemose, Rolf Schulte, Esben SS Hansen, Christoffer Laustsen<br> Contact: Nikolaj Bøgh at nikolaj.boegh@clin.au.dk</p> <p><br> ### DESCRIPTION OF DATASET</p> <p>This dataset contains images and spectra of healthy volunteers imaged with deuterium metabolic imaging. The data files are structured as subject (sub-xx) —> session (ses-xx) —> run (run-xx). Each subject (n=6) were imaged at two sessions 6 weeks apart.<br> Each session consisted of 4 runs:<br> ⁃ run-01 before 2H-glucose administration<br> ⁃ run-02 30 minutes after 2h-glucose<br> ⁃ run-03 75 minutes after 2h-glucose<br> ⁃ run-04 120 minutes after 2h-glucose</p> <p>At each run, a T1-weighted anatomical image was acquired. In this public dataset, a defaced version is provided. The anatomical images are accompanied by the DMI data, consisting of NIFTI-files of the fitted metabolite maps and a .-mat file with the raw MRSI data.</p>
Multi-frequency Bioelectrical Impedance for Estimating Total Body Water by Deuterium Dilution
ClinicalTrials.gov study NCT01607229. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Deuterium Metabolic Imaging to Assess Radiotherapy Changes in Glioblastoma Multiforme
ClinicalTrials.gov study NCT05908669. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
New Method Using Deuterium Labelled Creatine to Measure Total Body Skeletal Muscle Mass
ClinicalTrials.gov study NCT02519751. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study on Water Turnover of the Chinese Population Based on Deuterium Dilution Method
ClinicalTrials.gov study NCT07028021. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Deuterium Metabolic Imaging in People with Multiple Sclerosis
ClinicalTrials.gov study NCT06611280. IPD Sharing: NO. Countries: 1. Publications: 0.
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide
ClinicalTrials.gov study NCT06269653. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Glucose Metabolism in Brown Adipose Tissue (BAT) in Young Healthy Men Evaluated by Deuterium Metabolic Imaging (DMI)
ClinicalTrials.gov study NCT04060745. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Measurement of Lipogenic Flux by Deuterium Resolved Mass Spectrometry Via Non-invasive Breath Analysis
ClinicalTrials.gov study NCT05274334. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Deuterium Metabolic MRI and [18F]FDG PET for Assessment of Treatment Response Following Radioembolization
ClinicalTrials.gov study NCT06232889. IPD Sharing: Not stated. Countries: 1. Publications: 0.
TES/Aura L2 Deuterium Oxide Nadir V008
TL2HDON_8 is the Tropospheric Emission Spectrometer (TES)/Aura Level 2 Deuterium Oxide Nadir Version 8 data product. TES was an instrument aboard NASA's Aura satellite and was launched from California on July 15, 2004. Data collection for TES is complete. TES Level 2 data contains retrieved species (or temperature) profiles at the observation targets and the estimated errors. The geolocation, quality, and other data (e.g., surface characteristics for nadir observations) were also provided. L2 modeled spectra were evaluated using radiative transfer modeling algorithms. The process, referred to as retrieval, compared observed spectra to the modeled spectra and iteratively updated the atmospheric parameters. L2 standard product files included information for one molecular species (or temperature) for an entire global survey or special observation run. A global survey consisted of a maximum of 16 consecutive orbits. A nadir sequence within the TES Global Survey was a fixed number of observations within an orbit for a Global Survey. Prior to April 24, 2005, it consisted of two low resolution scans over the same ground locations. After April 24, 2005, Global Survey data consisted of three low resolution scans. The Nadir standard product consisted of four files, where each file was composed of the Global Survey Nadir observations from one of four focal planes for a single orbit, i.e. 72 orbit sequences. The Global Survey Nadir observations only used a single set of filter mix. A Global Survey consisted of observations along 16 consecutive orbits at the start of a two day cycle, over which 3,200 retrievals were performed. Each observation was the input for retrievals of species volume mixing ratios (VMRs), temperature profiles, surface temperature and other data parameters with associated pressure levels, precision, total error, vertical resolution, total column density, and other diagnostic quantities. Each TES Level 2 standard product reported information in a swath format conforming to the HDF-EOS Aura File Format Guidelines. Each Swath object was bounded by the number of observations in a global survey and a predefined set of pressure levels representing slices through the atmosphere. Each standard product could have had a variable number of observations depending upon the Global Survey configuration and whether averaging is employed. Also, missing or bad retrievals were not reported. The organization of data within the Swath object was based on a superset of the Upper Atmosphere Research Satellite (UARS) pressure levels that was used to report concentrations of trace atmospheric gases. The reporting grid was the same pressure grid used for modeling. There were 67 reporting levels from 1211.53 hPa, which allowed for very high surface pressure conditions, to 0.1 hPa, about 65 km. In addition, the products reported values directly at the surface when possible or at the observed cloud top level. Thus in the Standard Product files each observation could potentially contain estimates for the concentration of a particular molecule at 67 different pressure levels within the atmosphere. However, for most retrieved profiles, the highest pressure levels were not observed due to a surface at lower pressure or cloud obscuration. For pressure levels corresponding to altitudes below the cloud top or surface, where measurements were not possible, a fill value was applied.To minimize the duplication of information between the individual species standard products, data fields common to each species (such as spacecraft coordinates, emissivity, and other data fields) have been collected into a separate standard product, termed the TES L2 Ancillary Data product (ESDT short name: TL2ANC). Users of this product should also obtain the Ancillary Data product.
TES/Aura L2 Deuterium Oxide Nadir Special Observation V008
TL2HDONS_8 is the Tropospheric Emission Spectrometer (TES)/Aura Level 2 Deuterium Oxide Nadir Special Observation Version 8 data product. TES was an instrument aboard NASA's Aura satellite and was launched from California on July 15, 2004. Data collection for TES is complete. TES Level 2 data contain retrieved species (or temperature) profiles at the observation targets and the estimated errors. The geolocation, quality, and other data (e.g., surface characteristics for nadir observations) were also provided. L2 modeled spectra were evaluated using radiative transfer modeling algorithms. The process, referred to as retrieval, compared observed spectra to the modeled spectra and iteratively updated the atmospheric parameters. L2 standard product files included information for one molecular species (or temperature) for an entire global survey or special observation run. A global survey consisted of a maximum of 16 consecutive orbits. Nadir observations, which point directly to the surface of the Earth are different from limb observations, which are pointed at various off-nadir angles into the atmosphere. Nadir and limb observations were added to separate L2 files, and a single ancillary file was composed of data that are common to both nadir and limb files. A Nadir sequence within the TES Global Survey was a fixed number of observations within an orbit for a Global Survey. Prior to April 24, 2005, it consisted of two low resolution scans over the same ground locations. After April 24, 2005, Global Survey data consisted of three low resolution scans. The Nadir standard product consists of four files, where each file is composed of the Global Survey Nadir observations from one of four focal planes for a single orbit, i.e. 72 orbit sequences. The Global Survey Nadir observations only used a single set of filter mix. A Global Survey consisted of observations along 16 consecutive orbits at the start of a two day cycle, over which 3,200 retrievals were performed. Each observation was the input for retrievals of species Volume Mixing Ratios (VMRs), temperature profiles, surface temperature, and other data parameters with associated pressure levels, precision, total error, vertical resolution, total column density, and other diagnostic quantities. Each TES Level 2 standard product reported information in a swath format conforming to the HDF-EOS Aura File Format Guidelines. Each Swath object was bounded by the number of observations in a global survey and a predefined set of pressure levels representing slices through the atmosphere. Each standard product could have had a variable number of observations depending upon the Global Survey configuration and whether averaging was employed. Also, missing or bad retrievals were not reported. Further, observations were occasionally scheduled on non-global survey days. In general they were measurements made for validation purposes or with highly focused science objectives. Those non-global survey measurements were referred to as “special observations”The organization of data within the Swath object was based on a superset of the Upper Atmosphere Research Satellite (UARS) pressure levels used to report concentrations of trace atmospheric gases. The reporting grid was the same pressure grid used for modeling. There were 67 reporting levels from 1211.53 hPa, which allowed for very high surface pressure conditions, to 0.1 hPa, about 65 km. In addition, the products reported values directly at the surface when possible or at the observed cloud top level. Thus in the Standard Product files, each observation could potentially contain estimates for the concentration of a particular molecule at 67 different pressure levels within the atmosphere. However, for most retrieved profiles, the highest pressure levels were not observed due to a surface at lower pressure or cloud obscuration. For pressure levels corresponding to altitudes below the cloud top or surface, where measurements were not possible, a fill value was applied.To minimize the duplication of information between the individual species standard products, data fields common to each species (such as spacecraft coordinates, emissivity, and other data fields) was collected into a separate standard product, termed the TES L2 Ancillary Data product (Short name: TL2ANC). Users of this product should also obtain the Ancillary Data product.
Effect of deuterium oxide on Arabidopsis gene expression
GEO Series GSE18153. Arabidopsis thaliana. 15 samples. Type: Expression profiling by array.
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