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305 results for “Diabetic kidney disease”
Evaluating Comparative Effectiveness of Empagliflozin in Type 2 Diabetes Population With and Without Chronic Kidney Disease
ClinicalTrials.gov study NCT05465317. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease
ClinicalTrials.gov study NCT02540993. IPD Sharing: Not stated. Countries: 48. Publications: 28.
Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease
ClinicalTrials.gov study NCT02545049. IPD Sharing: NO. Countries: 48. Publications: 20.
Effects of Febuxostat on Adipokines and Kidney Disease in Diabetic Chronic Kidney Disease
ClinicalTrials.gov study NCT01350388. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease
ClinicalTrials.gov study NCT03819153. IPD Sharing: YES. Countries: 28. Publications: 11.
Data from: DNA methylation changes associated with type 2 diabetes and diabetic kidney disease in an East Asian population
<p><b>Objective:</b> There is growing body of evidence that epigenetic changes including DNA methylation influence the risk of type 2 diabetes and its microvascular complications. We conducted a methylome-wide association study (MWAS) to identify differentially methylated regions (DMRs) of type 2 diabetes and diabetic kidney disease (DKD) in Korean population.</p> <p><b>Methods:</b> We performed an initial MWAS in 232 participants in a case-control study design with type 2 diabetes and 197 non-diabetic controls with Illumina EPIC bead chip using peripheral blood leukocytes. Type 2 diabetes group was subdivided to 87 DKD cases and 80 non-DKD controls. Additional 819 individuals from two population-based cohorts were used to investigate the association of the identified DMRs with quantitative metabolic traits. We developed a DNA methylation score using identified DMRs to predict the occurrence of type 2 diabetes. To examine the causal relationship between the metabolic traits and differentially methylated status, we performed Mendelian randomization (MR) analyses.</p> <p><b>Results:</b> We identified eight DMRs (each at <i>BMP8A</i>, <i>NBPF20, STX18, ZNF365, CPT1A,</i> and <i>TRIM37</i>, and two at <i>TXNIP</i>) which were significantly associated with risk of type 2 diabetes (P < 9.0×10<sup>-8</sup>), including three that were previously known (DMRs in <i>TXNIP</i> and<i> CPT1A</i>), in 429 type 2 diabetes cases and controls. DNA methylation score consisted of these DMRs differentiated the risk of developing type 2 diabetes in an independent prospective cohort with a relative risk of 2.44 (95% confidence interval 1.39–4.28) between the lowest and highest deciles of DNA methylation score. DMRs in <i>CPT1A</i> and <i>TXNIP</i> were associated with quantitative metabolic traits, including fasting glucose, HbA1c, and body mass index. We also identified three DMRs (on <i>COMMD1</i>, <i>TMOD1</i>, and <i>FHOD1</i>) associated with DKD in 167 DKD cases and controls. The DMRs of DKD did not show meaningful overlap with those of type 2 diabetes. In MR analysis, the estimated glomerular filtration rate was causally associated with DNA methylation of these three DMRs.</p> <p><b>Conclusions</b>: In an East Asian population, we identified eight DMRs, including five novel ones, associated with type 2 diabetes and three DMRs associated with DKD at methylome-wide statistical significance. Our findings suggest that epigenetics of DKD may share little with those responsible for the development of type 2 diabetes.</p>
An Observational Study, Called FINEGUST, to Learn More About How People With Chronic Kidney Disease and Type 2 Diabetes Are Treated and How the Introduction of New Treatment Options, Like Finerenone,
ClinicalTrials.gov study NCT05526157. IPD Sharing: NO. Countries: 5. Publications: 1.
A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
ClinicalTrials.gov study NCT05936151. IPD Sharing: YES. Countries: 5. Publications: 0.
Randomized Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease
ClinicalTrials.gov study NCT04626323. IPD Sharing: NO. Countries: 1. Publications: 59.
A Study of Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus With Chronic Kidney Disease or Kidney Failure on Dialysis (MK-3102-019)
ClinicalTrials.gov study NCT01698775. IPD Sharing: Not stated. Countries: 0. Publications: 1.
NEPHSTROM for Diabetic Kidney Disease
ClinicalTrials.gov study NCT02585622. IPD Sharing: NO. Countries: 3. Publications: 2.
Assessement of the Knoweldge ,Attitudes,Practices of Diabetic Kidney Disease Among Diabetic Patients
ClinicalTrials.gov study NCT06927921. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 3 Study of Bardoxolone Methyl in Patients With Diabetic Kidney Disease; AYAME Study
ClinicalTrials.gov study NCT03550443. IPD Sharing: NO. Countries: 1. Publications: 1.
Go Fish: Omega-3 Fatty Acid Supplementation in Diabetes-Related Kidney Disease
ClinicalTrials.gov study NCT01092390. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Simultaneous Islet-Kidney Transplantation in Patients of Type 1 Diabetes With End-stage Renal Disease
ClinicalTrials.gov study NCT00692562. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of GLP-1 RAs Compared to Basal Insulin Start in Patients Living With Type 2 Diabetes and Chronic Kidney Disease
ClinicalTrials.gov study NCT06236672. IPD Sharing: NO. Countries: 1. Publications: 0.
Association of BsmI Polymorphisms in Vitamin D Receptor Gene With Diabetic Kidney Disease
ClinicalTrials.gov study NCT03621384. IPD Sharing: UNDECIDED. Countries: 1. Publications: 13.
A Study Using the LMC Diabetes Registry to Learn More About Chronic Kidney Disease (CKD) in Canadian Patients With Type 2 Diabetes (T2D)
ClinicalTrials.gov study NCT04445181. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy of N-Acetylcysteine in Prevention of Post-Catheterization Contrast-Induced Nephropathy in Diabetic Patients With Chronic Kidney Disease
ClinicalTrials.gov study NCT00808795. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Using a Diabetic Kidney Disease (DKD) Registry to Treat to Multiple Targets (TMT)
ClinicalTrials.gov study NCT02176278. IPD Sharing: NO. Countries: 7. Publications: 7.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.