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130 results for “Dietary restriction”
The hidden costs of dietary restriction: implications for its evolutionary and mechanistic origins
<p></p><p>Dietary restriction (DR) extends life span across taxa. Despite considerable research, universal mechanisms of DR have not been identified, limiting its translational potential. Guided by the conviction that DR evolved as an adaptive, pro-longevity physiological response to food scarcity, biomedical science has interpreted DR as an activator of pro-longevity molecular pathways. Current evolutionary theory predicts that organisms invest in their soma during DR, and thus when resource availability improves, should outcompete rich-fed controls in survival and/or reproduction. Testing this prediction in Drosophila melanogaster (N > 66,000 across 11 genotypes), our experiments revealed substantial, unexpected mortality costs when flies returned to a rich diet following DR. The physiological effects of DR should therefore not be interpreted as intrinsically pro-longevity, acting via somatic maintenance. We suggest DR could alternatively be considered an escape from costs incurred under nutrient-rich conditions, in addition to costs associated with DR.</p><p></p>
DIetary REstriction as an Adjunct to Neoadjuvant ChemoTherapy for HER2 Negative Breast Cancer
ClinicalTrials.gov study NCT02126449. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Time-restricted Feeding as a Dietary Strategy Against Metabolic Disturbances in Humans
ClinicalTrials.gov study NCT04351672. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Metabolic Impact on the Mitochondria-gut Microbiota Axis of Failure to Follow Restrictive Dietary Interventions in Subjects Living With Obesity
ClinicalTrials.gov study NCT06782009. IPD Sharing: NO. Countries: 1. Publications: 2.
The Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function.
ClinicalTrials.gov study NCT06151015. IPD Sharing: YES. Countries: 1. Publications: 7.
Assessments of Dietary Restrictions in Young and Elderly Obese Men : Metabolism Obesity Nutrition Age
ClinicalTrials.gov study NCT02161926. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Determination of the Effect of Extreme Dietary Carbohydrate Restriction on Hepatic Glucose Production
ClinicalTrials.gov study NCT01262326. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of Dietary Restrictions and Ketogenic Diet on Mitochondrial Function and Gut Microbiota in Subjects With Obesity
ClinicalTrials.gov study NCT05200468. IPD Sharing: NO. Countries: 1. Publications: 12.
Metformin and Dietary Restriction to Prevent Age-related Morbid Events in People With Metabolic Syndrome
ClinicalTrials.gov study NCT02960711. IPD Sharing: NO. Countries: 1. Publications: 4.
Effect of Dietary Protein and Energy Restriction in the Improvement of Insulin Resistance in Subjects With Obesity
ClinicalTrials.gov study NCT03627104. IPD Sharing: NO. Countries: 1. Publications: 21.
Effects of Auricular Acupressure Versus Intermittent Dietary Restriction in Children With Gastric Heat and Dampness Obstruction
ClinicalTrials.gov study NCT05847478. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Dietary Sodium Restriction in the Management of Patients With Heart Failure and Diastolic Dysfunction
ClinicalTrials.gov study NCT01896908. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Dietary Restriction in Vascular Surgery
ClinicalTrials.gov study NCT04013412. IPD Sharing: NO. Countries: 1. Publications: 8.
Short- and Longterm Effects of Physical Activity and Dietary Restriction Postpartum
ClinicalTrials.gov study NCT01343238. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Dietary Energy Restriction and Metabolic Aging in Humans
ClinicalTrials.gov study NCT00183027. IPD Sharing: Not stated. Countries: 1. Publications: 9.
The Mediterranean Diet and Time-Restricted Eating Dietary Interventions for Psoriasis Study
ClinicalTrials.gov study NCT05820698. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Study Comparing Effects of Lanthanum Carbonate Versus Calcium Acetate Versus Dietary Phosphorus Restriction
ClinicalTrials.gov study NCT01357317. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Restriction of Dietary AGEs to Prevent Diabetes in Overweight Individuals
ClinicalTrials.gov study NCT03866343. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine Dependent Epilepsy Patients
ClinicalTrials.gov study NCT01795170. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Data from: Evolution under dietary restriction increases male reproductive performance without survival cost
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OpenNeuro
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