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137 results for “Domain specificity”
Figure 2. Rubicon and Pacer RH domain have inverted pRAB7A binding specificity [FINAL]
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Label-Free Quantification (LFQ) LC-MS Data for the Profiling of Domain-specific VCP/p97 Interactions in Living Cells
<p>This deposit includes LFQ LC-MS data for tandem-IP samples from VCP-L278AbK and VCP-D592AbK crosslinking experiments, their VCP-L278BocK and VCP-D592BocK controls, and SpectroMine output files.</p>
Genetic variation in cis-regulatory domains suggests cell type-specific regulatory mechanisms in immunity
<p>1- workflow for data analysis and figures generation</p>
Dataset: Maturity Evaluation of Domain-Specific Language Ecosystems for Cyber-Physical Production Systems
<p>This online repository contains the accompanying data for the ETFA publication "Maturity Evaluation of Domain-Specific Language Ecosystems for Cyber-Physical Production Systems".<br> <br> This involves all tables which contain the values of the maturity evaluation criteria of the five examined subject DSLs.</p>
Systematic Mapping Study on Domain-Specific Language Development Tools - Data Repository
<p>Domain-specific languages (DSL) are programming or modeling languages devoted to a given application domain. There are many tools used to support the implementation of a DSL, making hard the decision-making process for one or another. In this sense, identifying and mapping their features is relevant for decision-making by academic and industrial initiative on DSL development. <br> Objective: The goal of this work is to identify and map the tools, Language Workbenches (LW), or frameworks that were proposed to develop DSLs discussed and referenced in publications between 2012 and 2019. <br> Method: A Systematic Mapping Study (SMS) of the literature scoping tools for DSL development. <br> Results: We identified 59 tools, including 9 under a commercial license and 41 with non-commercial licenses, and analyzed their features from 230 papers. <br> Conclusion: There is a substantial amount of tools that cover a large number of features. Furthermore, we observed that usually, the developer adopts one type of notation to implement the DSL: textual or graphical. We also discussed research gaps, such as a lack of tools that allow meta-meta model transformations and that support modeling tools interoperability. </p>
Electrophysiological recordings showing allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains with specific sybodies
<p>Members of the LRRC8 family form heteromeric assemblies, which function as volume-regulated anion channels. These modular proteins consist of a transmembrane pore and cytoplasmic leucine-rich repeat (LRR) domains. Despite their known molecular architecture, the mechanism of activation and the role of the LRR domains in this process has remained elusive. Here we have addressed this question by generating synthetic nanobodies, termed sybodies, which target the LRR domain of the obligatory subunit LRRC8A.We used these binders to investigate their interaction with homomeric LRRC8A channels by cryo-electron microscopy and the consequent effect on channel activation by electrophysiology. The five identified sybodies either inhibit or enhance activity by binding to distinct epitopes of the LRR domain, thereby altering channel conformations. In combination, our work provides a set of specific modulators of LRRC8 proteins and reveals the role of their cytoplasmic domains as regulators of channel activity by allosteric mechanisms.</p>
Supplementary materials for paper: A domain-specific language for precision agriculture
<p>Supplementary materials for paper: A domain-specific language for precision agriculture</p>
Data from: The domain specificity of intertemporal choice in pinyon jays
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Electrophysiological recordings showing allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains with specific sybodies
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Data from: Domain-specific functions of Stardust in Drosophila embryonic development
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Data from: Neural correlates of domain-specific cognitive decline: the ARIC-NCS study
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RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific
GEO Series GSE215198. synthetic construct. 667 samples. Type: Expression profiling by array.
Lineage-specific reorganization of nuclear peripheral heterochromatin and H3K9me2 domains
GEO Series GSE121314. Mus musculus. 33 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation [WGBS]
GEO Series GSE210218. Homo sapiens. 2 samples. Type: Methylation profiling by high throughput sequencing.
PU.1 Eviction at Lymphocyte-Specific Chromatin Domains Mediates Glucocorticoid Response in Acute Lymphoblastic Leukemia
GEO Series GSE236085. Homo sapiens. 21 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
A PWWP domain-containing protein Crf4-3 specifically modulates fungal azole susceptibility by regulating sterol C-14 demethylase ERG11
GEO Series GSE272185. Neurospora crassa. 12 samples. Type: Expression profiling by high throughput sequencing.
Replacing C189 in the bZIP domain of Zta to S, T, V, and A changes DNA binding specificity to four types of double-stranded DNA (mC)
GEO Series GSE108272. synthetic construct; human gammaherpesvirus 4. 29 samples. Type: Other.
Proliferative Receptor Binding Domain (RBD)-specific CD4+ T cells correlate with neutralizing antibody levels after natural SARS-CoV-2 infection and are induced following vaccination
GEO Series GSE198281. Homo sapiens; synthetic construct. 6 samples. Type: Expression profiling by high throughput sequencing.
PGC methylome analysis revealed large, germline-specific mouse hypomethylated DNA domains with unique genomic and epigenomic features [DNA methylation_NimbleGen]
GEO Series GSE39794. Mus musculus. 32 samples. Type: Methylation profiling by genome tiling array.
Cancer-specific retargeting of BAF complexes by a prion-like domain [RNA-Seq]
GEO Series GSE94277. Homo sapiens. 29 samples. Type: Expression profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.