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204
datasets available to search
ShareScore release 0.9.0
Dataset results
204 results for “Drug-resistance”
Transformable nano-antibiotics for mechanotherapy and immune activation against drug-resistant Gram-negative bacteria
<p><span>The dearth of antibiotic candidates against Gram-negative bacteria and the rise of antibiotic resistance create a global health concern. The challenge lies in the unique Gram-negative bacterial outer membrane that provides the impermeable barrier for antibiotics and sequesters antigen presentation. We designed a transformable nano-antibiotics (TNA) which can transform from nontoxic nanoparticles to bactericidal nanofibrils with reasonable rigidity (Young's modulus, 21.6 ± 5.9 MPa) after targeting β-barrel assembly machine A (BamA) and lipid polysaccharides (LPS) of Gram-negative bacteria. After morphological transformation, the TNA can penetrate and damage the bacterial envelope, disrupt electron transport and multiple conserved biosynthetic and metabolic pathways, burst bacterial antigen release from the outer membrane, and subsequently activate innate and adaptive immunity. TNA kills Gram-negative bacteria in vitro and in vivo with undetectable resistance through multiple bactericidal modes of action. TNA-treatment-induced vaccination results in rapid and long-lasting immune responses, protecting against lethal re-infections.</span></p>
Efficacy, Tolerability and Adherence of the Modified Atkins Diet on Drug-resistant Epilepsy
ClinicalTrials.gov study NCT03183076. IPD Sharing: NO. Countries: 1. Publications: 30.
Study of 6b11-OCIK Injection Treatment in Patients With Recurrent Drug-resistant Ovarian Cancer
ClinicalTrials.gov study NCT03542669. IPD Sharing: NO. Countries: 1. Publications: 1.
Ultralow Dose Computed Tomography in High-risk Drug-resistant Tuberculosis Contacts
ClinicalTrials.gov study NCT02454738. IPD Sharing: YES. Countries: 1. Publications: 1.
PRediction of Vagal Nerve Stimulation EfficaCy In Drug-reSistant Epilepsy
ClinicalTrials.gov study NCT04935567. IPD Sharing: NO. Countries: 1. Publications: 1.
The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children
ClinicalTrials.gov study NCT05697614. IPD Sharing: NO. Countries: 1. Publications: 1.
Real-World Study of Magnetic Resonance-guided Laser Interstitial Thermal Therapy for Drug-resistant Epilepsy
ClinicalTrials.gov study NCT06341075. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
IF-MCT 16:8: Investigating the Influence of Intermittent Fasting With and Without MCTs in Patients With Drug-resistant Epilepsy
ClinicalTrials.gov study NCT06013761. IPD Sharing: NO. Countries: 1. Publications: 0.
Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients
ClinicalTrials.gov study NCT05339438. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
The Individualized M(X) Drug-resistant TB Treatment Strategy Study
ClinicalTrials.gov study NCT03237182. IPD Sharing: YES. Countries: 1. Publications: 3.
Patient-derived Organoid Drug Sensitivity Guided Treatment for Drug-resistant Recurrent Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT06406608. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Determinants of Adaptive Behavior Through the Vineland Scale in Pediatric Patients with Severe and Drug-resistant Epilepsy
ClinicalTrials.gov study NCT06832020. IPD Sharing: YES. Countries: 1. Publications: 8.
Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))
ClinicalTrials.gov study NCT05135091. IPD Sharing: NO. Countries: 1. Publications: 1.
Exploring the Characteristics of Epileptogenic Foci in Drug-Resistant Epilepsy Based on Multimodal Imaging Technology
ClinicalTrials.gov study NCT06557720. IPD Sharing: NO. Countries: 1. Publications: 6.
Italian Registry of HIV-1 Infected Patients With Drug-RESistant Virus to Reverse Transcriptase Inhibitors, InteGrasE and Viral Protease.
ClinicalTrials.gov study NCT04098315. IPD Sharing: YES. Countries: 1. Publications: 3.
Genetic and Electrophysiologic Study in Focal Drug-resistant Epilepsies
ClinicalTrials.gov study NCT02890641. IPD Sharing: Not stated. Countries: 1. Publications: 9.
The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major Depression
ClinicalTrials.gov study NCT02037503. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Recording "Fast Ripples" Using Microelectrodes During Stereo-encephalography in Patients With Drug-resistant Partial Epilepsy
ClinicalTrials.gov study NCT02491476. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Biomarkers for Therapy Response in Drug-resistant Tuberculosis
ClinicalTrials.gov study NCT02597621. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Linezolid Dosing Strategies in Drug-Resistant TB
ClinicalTrials.gov study NCT05007821. IPD Sharing: YES. Countries: 7. Publications: 0.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.