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1,301 results for “Epilepsy”
Dataset to 'Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy '
<p>Dataset to 'Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy '</p> <div> <div>For the linked publication see: <a href="https://doi.org/10.1162/netn_a_00362" target="_blank" rel="noopener">https://doi.org/10.1162/netn_a_00362</a></div> <div> </div> </div> <p><em>eeg-fmri_$dataset$_$group$_connectomes_desikan_scrubbed.mat</em><br>datasets with filename truncTo5min hold static connectivities based on timeseries truncated<br>to 5min. All other datasets are based on static connectivities derived from the total session<br>timeseries.</p> <p><br>subj: subject<br>subj.name: name of the subject<br>subj.sess: session<br>subj.sess.sess_name: name of the session<br>subj.sess.fMRI: vector of upper triangular of fMRI connectivity<br>subj.sess.EEG: EEG connectomes<br>subj.sess.EEG.name: name of connectivity measure used (corrected imaginary part of the coherency: iCoh)<br>subj.sess.EEG.bands: EEG frequency bands<br>subj.sess.EEG.bands.name: name of frequency band (delta, theta, alpha, beta, gamma)<br>subj.sess.EEG.bands.name.conn: vector of upper triangular of EEG connectivity<br>subj.atlas: Atlas<br>subj.atlas.name: name of atlas used (Desikan)<br>subj.atlas.regions: number of regions</p> <p><em>$dataset$_$group$_</em>particpants.tsv: Subject metadata</p> <p><em>$dataset$_$group$_spikes.mat: Interictal epileptoform discharges (IEDs) marked for each session of TLE patients</em></p> <p><em>aparc_aseg_yeoR7_68reg_eeg_nosubc_cmfg2dan.mat: mapping of Desikan regions to Yeo7-networks (Yeo et al. 2011, JNP)</em></p> <p><em>desi_coord_68.txt: MNI coordinates of region centers of the Desikan atlas<br></em></p> <p><em>For the related code to this dataset please clone: </em>https://github.com/jwirsich/eeg-fmri-tle or use the code provided in 'eeg-fmri-tle-code.zip'</p>
Raw Data for the article: Functional Gastrointestinal Disorders in Patients With Epilepsy: Reciprocal Influence and Impact on Seizure Occurrence
<p><strong>Introduction:</strong> The complex relationship between the microbiota-gut-brain axis (MGBA) and epilepsy has been increasingly investigated in preclinical studies. Conversely, evidence from clinical studies is still scarce. In recent years, the pivotal role of MGBA dysregulation in the pathophysiology of functional gastrointestinal disorders (FGID) has been recognized. With this background, we aimed to investigate the prevalence of FGID in patients with epilepsy (PWE) and the possible impact of bowel movement abnormalities on seizure recurrence. <strong>Methods:</strong> A total of 120 PWE and 113 age-, sex-, and BMI-matched healthy subjects (HS) were consecutively enrolled. A questionnaire to evaluate the presence of FGID (according to Rome III diagnostic criteria) was administrated to all participants. In a subgroup of drug-resistant patients, we administered an <em>ad-hoc</em> questionnaire combining Bristol stool charts and seizure diaries to evaluate seizure trends and bowel movement changes. <strong>Results:</strong> A higher prevalence of FGID in PWE (62.5%) than in HS (39.8%) was found (<em>p</em> < 0.001). The most frequently observed disorder was constipation, which was significantly higher in PWE than in HS (43.3 vs. 21.2%, <em>p</em> < 0.001), and was not associated with anti-seizure medication intake according to multivariable analysis. In drug-resistant patients, most seizures occurred during periods of altered bowel movements, especially constipation. A significant weak negative correlation between the number of days with seizures and the number of days with normal bowel movements was observed (<em>p</em> = 0.04). According to multivariable logistic regression analysis, FGID was significantly associated with temporal lobe epilepsy as compared with other lobar localization (<em>p</em> = 0.03). <strong>Conclusions:</strong> Our clinical findings shed new light on the complex relationship between epilepsy and the MGBA, suggesting a bidirectional link between bowel movement abnormalities and seizure occurrence. However, larger studies are required to better address this important topic.</p>
Patient-reported outcomes via electronic health record portal vs. telephone: process and retention data in a pilot trial of anxiety or depression symptoms in epilepsy
<p>Objective: To close gaps between research and clinical practice, tools are needed for efficient pragmatic trial recruitment and patient-reported outcome(PROM) collection. The objective was to assess feasibility and process measures for patient-reported outcome collection in a randomized trial comparing electronic health record(EHR) patient portal questionnaires to telephone interview among adults with epilepsy and anxiety or depression symptoms.</p> <p>Results: Participants were 60% women, 77% White/non-Hispanic, with mean age 42.5 years. Among 15 individuals randomized to EHR portal, 10(67%, CI 41.7-84.8%) met the 6-month retention endpoint, versus 100%(CI 79.6-100%) in the telephone group(p=0.04). EHR outcome collection at 6 months required 11.8 minutes less research staff time per participant than telephone (5.9, CI 3.3-7.7 vs. 17.7, CI 14.1-20.2). Subsequent telephone contact after unsuccessful EHR attempts enabled near complete data collection and still saved staff time.</p> <p>Discussion: Data from this randomized pilot study of pragmatic outcome collection methods for patients with anxiety or depression symptoms in epilepsy includes baseline participant characteristics, recruitment flow resulting from a novel EHR-based, care-embedded recruitment process, and data on retention along with various process measures at 6-months.</p>
Data: Computer modelling of connectivity change suggests epileptogenesis mechanisms in idiopathic generalised epilepsy
<p>We provide the generalised fractional anisotropy connectometry database used in our study titled: <em>Computer modelling of connectivity change suggests epileptogenesis mechanisms in idiopathic generalised epilepsy.</em></p>
Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: a randomized proof-of-concept clinical trial
<p>Open dataset for a proof-of-concept randomized clinical trial with a four month follow-up period was conducted to investigate whether ivermectin had an added value in decreasing the frequency of seizures in onchocerciasis-infected persons with epilepsy (PWE). The 90 PWE with epilepsy were randomly allocated to the treatment arms: phenobarbital + ivermectin (n = 44) or phenobarbital alone (n = 46). Two weeks after randomization, a follow-up visit was scheduled to assess the early treatment outcomes and potential side effects of AED. After the second week visit, PWE had to report to the health center for further follow-up consultations by the project nurses and medical doctors, scheduled at 1, 2, 3 and 4 months. By March 2018, 89 (99%) participants in both arms attended the final follow-up visit. The trial was conducted in five onchocerciasis-endemic villages within the Logo health zone in the Ituri province, DRC: Draju, Kanga, Wala, Ulyeko and Thedeja. </p> <p>At baseline, information was collected on seizure semiology, seizure frequency, epilepsy risk factors, relevant medical history, previous AED and ivermectin use. Weight and height measurements were carried out on all participants, followed by a complete physical and neurological examination performed by one of the medical doctors who had been trained in epilepsy, or by the neurologist. Cognitive impairment was assessed by determining whether the participant was well oriented in time and place, whether he/she could remember his/her name, was coherent in speech, and was obedient to orders; abnormal behaviour such as unexplained aggressive attitudes and/or wandering episodes were also noted.</p> <p> </p> <p> </p>
Fig. 2 in Establishment of the sea grape flatid, Petrusa epilepsis (Hemiptera: Fulgoroidea: Flatidae), in Florida
Fig. 2. Petrusa epilepsis feeding on stem of Hamelia patens (firebush).
Fig. 3 in Establishment of the sea grape flatid, Petrusa epilepsis (Hemiptera: Fulgoroidea: Flatidae), in Florida
Fig. 3. Petrusa epilepsis feeding on inflorescence of Stachytarpheta jamaicensis (blue porterweed).
Dataset on household survey on the prevalence of epilepsy in onchocerciasis endemic communities in the Bono Region of Ghana
<p>Household survey on prevalence of epilepsy in onchocerciasis endemic communities in the Bono Region of Ghana</p>
Intracranial EEG Structure-Function Coupling and Seizure Outcomes After Epilepsy Surgery
<p>iEEGnetworksFC: Functional Connectivity Networks</p> <p>iEEGnetworkSCPre: Structural Connectivity Networks before surgery</p> <p>iEEGnetworkSCPost: Structural Connectivity Networks expected after surgery</p> <p>iEEGnetworkSCPre5mm: Structural Connectivity Networks before surgery with alternate ROI size of 5mm at each contact</p> <p> </p>
Study in Pediatric Subjects With Epilepsy
ClinicalTrials.gov study NCT01494584. IPD Sharing: Not stated. Countries: 1. Publications: 1.
PRX-00023 Therapy in Localization-Related Epilepsy
ClinicalTrials.gov study NCT01281956. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy(STANDLOW)
ClinicalTrials.gov study NCT03689114. IPD Sharing: NO. Countries: 1. Publications: 7.
Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy
ClinicalTrials.gov study NCT03373383. IPD Sharing: YES. Countries: 19. Publications: 2.
Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE)
ClinicalTrials.gov study NCT02383407. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Comparing Best Medical Practice With or Without VNS Therapy in Pharmacoresistant Partial Epilepsy Patients
ClinicalTrials.gov study NCT00522418. IPD Sharing: Not stated. Countries: 10. Publications: 17.
Safety & Efficacy of Eslicarbazepine Monotherapy in Sub.w/Partial Epilepsy Not Well Controlled by Current Antiepileptic
ClinicalTrials.gov study NCT01091662. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Repeat-Dose Pharmacokinetics Study of NRL-1 in Epilepsy Subjects
ClinicalTrials.gov study NCT02724423. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Levetiracetam Versus Oxcarbazepine as Monotherapy to Evaluate Efficacy and Safety in Subjects With Newly or Recently Diagnosed Partial Epilepsy
ClinicalTrials.gov study NCT01498822. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Treating Obstructive Sleep Apnea in Epilepsy
ClinicalTrials.gov study NCT00047463. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Prevalence and Risk Factors of Coagulopathy in Pediatric Epilepsy Surgery Patients
ClinicalTrials.gov study NCT05675254. IPD Sharing: NO. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.