Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
61
datasets available to search
ShareScore release 0.9.0
Dataset results
61 results for “Epileptic Seizure”
A Study Investigating the Anti-epileptic Efficacy of Afinitor (Everolimus) in Patients With Refractory Seizures Who Have Focal Cortical Dysplasia Type II (FCD II)
ClinicalTrials.gov study NCT03198949. IPD Sharing: NO. Countries: 1. Publications: 1.
Mortality in patients with psychogenic non-epileptic seizures
<p><span><b>Objective</b></span></p> <p><span>To investigate the hypothesis that patients diagnosed with PNES on video-EEG monitoring (VEM) have increased mortality by comparison to the general population. </span></p> <p> </p> <p><span><b>Methods</b></span></p> <p><span><span>This retrospective cohort study included patients evaluated in VEM units of three tertiary hospitals in Melbourne, Australia, between January 1<sup>st</sup>, 1995 and December 31<sup>st</sup>, 2015. Diagnosis was based on consensus opinion of experienced epileptologists and neuropsychiatrists at each hospital. </span>Mortality was determined <span>in patients diagnosed with PNES, epilepsy or both conditions,</span> by linkage to the Australian National Death Index (NDI)<span>. Lifetime history of psychiatric disorders in PNES was determined from formal neuropsychiatric reports. </span></span></p> <p> </p> <p><span><b>Results </b></span></p> <p><span>5,508 patients underwent VEM. 674 (12.2%) were diagnosed with PNES, 3064 (55.6%) with epilepsy, 175 (3.2%) with both conditions, and 1,595 (29.0%) received other diagnoses or had no diagnosis made. The standardised mortality ratio (SMR) of patients diagnosed with PNES was 2.5 (95% CI 2.0–3.3). Those younger than 30 years had an 8-fold higher risk of death (95% CI 3.4–19.8). Direct comparison revealed no significant difference in mortality rate between diagnostic groups. Amongst deaths in patients diagnosed with PNES (n=55), external causes contributed 18%, with 20% of deaths in those younger than 50 years attributed to suicide, and "epilepsy" was recorded as the cause of death in 24%. </span></p> <p> </p> <p><span><b>Conclusions </b></span></p> <p><span><span>Patients diagnosed with PNES have a SMR 2.5 times above the general population, dying at a rate comparable to those with drug-resistant epilepsy. This emphasises the importance of prompt diagnosis, identification of risk factors, and the implementation of appropriate strategies to prevent potential avoidable deaths.</span></span></p>
Supplemental methods for: Circulating plasma proteins differentiate epileptic from psychogenic non-epileptic seizures
<p><b>Objective:</b> To develop a diagnostic test that stratifies epileptic seizure (ES) from psychogenic non-epileptic seizure (PNES) by developing a multimodal algorithm that integrates plasma concentrations of selected immune response associated proteins and patient clinical risk factors for seizure.</p> <p><b>Methods: </b>Daily blood samples were collected from patients evaluated in the epilepsy monitoring unit (EMU) within 24 hours after EEG confirmed ES or PNES and plasma was isolated. Levels of 51 candidate plasma proteins were quantified using an automated, multiplexed, sandwich ELISA and then integrated and analyzed using our diagnostic algorithm.</p> <p><b>Results: </b>A 51 protein multiplexed ELISA panel was used to determine the plasma concentrations of ES patients, PNES patients, and healthy controls. A combination of protein concentrations, TRAIL, ICAM-1, MCP-2 and TNF-R1 were identified that provided a probability that a patient recently experienced a seizure. The diagnostic algorithm yielded an AUC of 0.94 ± 0.07, sensitivity of 82.6% (95% CI: 62.9-93.0) and specificity of 91.6% (95% CI: 74.2-97.7). Further, expanding the diagnostic algorithm to include previously identified PNES risk factors enhanced diagnostic performance with AUC of 0.97 ± 0.05, sensitivity of 91.3%; (95% CI: 73.2-97.6), and specificity of 95.8%; (95% CI: 79.8-99.3).</p> <p><b>Conclusions: </b>We have identified four plasma proteins that could provide a rapid, cost-effective, and accurate blood-based diagnostic test to confirm recent ES or PNES.</p> <p><b>Classification of Evidence</b>: This study provides Class III evidence that variable levels of four plasma proteins, when analyzed by a diagnostic algorithm, can distinguish PNES from ES with sensitivity of 82.6% and specificity of 91.6%.</p>
Impact of Self-visualization of Epileptic Seizures on Patients' Perception of the Disease and Risk Behavior
ClinicalTrials.gov study NCT04311151. IPD Sharing: NO. Countries: 0. Publications: 3.
A Study of Levetiracetam as Monotherapy or Adjunctive Treatment of Partial Seizures in Pediatric Epileptic Subjects Ranging From 1 Month to Less Than 4 Years of Age
ClinicalTrials.gov study NCT03340064. IPD Sharing: YES. Countries: 1. Publications: 0.
Trial to Assess Lacosamide as the First add-on Anti-epileptic Drug Treatment in Patients With Partial-onset Seizures
ClinicalTrials.gov study NCT00955357. IPD Sharing: Not stated. Countries: 15. Publications: 0.
An Open Label Study to Evaluate the Effects of Ezogabine/Retigabine Added to Existing Anti-epileptic Drug(s) on Urinary Voiding Function in Subjects With Partial Onset Seizures
ClinicalTrials.gov study NCT01607346. IPD Sharing: Not stated. Countries: 3. Publications: 0.
Electrical Brain Stimulation to Reduce Epileptic Seizures
ClinicalTrials.gov study NCT00344877. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Pharmacokinetic Study of a Single-Dose of Diazepam Nasal Spray in Adult Epileptic Patients Experiencing a Seizure Episode
ClinicalTrials.gov study NCT01417078. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Auricular Acupuncture For The Treatment Of Non-Epileptic Seizures
ClinicalTrials.gov study NCT01919307. IPD Sharing: NO. Countries: 1. Publications: 0.
Diagnostic Value of Smartphone Video in Epileptic Seizures
ClinicalTrials.gov study NCT05574725. IPD Sharing: Not stated. Countries: 0. Publications: 5.
A Long-term Extension Study of E2007 in Patients With Refractory Partial Seizures Uncontrolled With Other Anti-Epileptic Drugs (AEDs)
ClinicalTrials.gov study NCT00903786. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Motivational Interviewing to Enhance Adherence of Patients With Psychogenic Non-epileptic Seizures
ClinicalTrials.gov study NCT02598076. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Trial to Assess Vagus Nerve Stimulation Therapy vs. Anti-Epileptic Drug (AED) Treatment in Children With Refractory Seizures
ClinicalTrials.gov study NCT01118455. IPD Sharing: Not stated. Countries: 5. Publications: 0.
Psychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure
ClinicalTrials.gov study NCT00255411. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Mortality in patients with psychogenic non-epileptic seizures
Open the record for dataset details and reuse information.
Supplemental methods for: Circulating plasma proteins differentiate epileptic from psychogenic non-epileptic seizures
Open the record for dataset details and reuse information.
Identification of candidate genes for generalized tonic–clonic seizures in Noda Epileptic Rat
GEO Series GSE100366. Rattus norvegicus. 16 samples. Type: Expression profiling by array.
The Effect of Jigsaw Technique on Childhood Epileptic Seizure Management Knowledge and Attitudes of Nursing Students
ClinicalTrials.gov study NCT06400966. IPD Sharing: NO. Countries: 1. Publications: 0.
Volatile Non-Invasive Biomarkers of Epileptic Seizures
ClinicalTrials.gov study NCT05725174. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.