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268 results for “Erythropoiesis”
Hyperoxia, Erythropoiesis and Microcirculation in Critically Ill Patient
ClinicalTrials.gov study NCT02481843. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Renal Prognosis in Chronic Kidney Disease Patients With Hyporesponsive Anemia to Erythropoiesis Stimulating Agents
ClinicalTrials.gov study NCT02136563. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The transcriptomic landscape of normal and ineffective erythropoiesis at single cell resolution
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Data from: Evolutionary suppression of erythropoiesis via the modulation of TGF-β signaling in an Antarctic icefish
The Antarctic icefish, a family (Channichthyidae) of teleosts within the perciform suborder Notothenioidei, are the only known vertebrates without oxygen-transporting haemoglobins and that are largely devoid of circulating erythrocytes. To elucidate the evo-devo mechanisms underpinning the suppressed erythropoiesis in the icefish, we conducted comparative studies on the transcriptomes and microRNAomes of the primary haematopoietic tissues between an icefish (Chionodraco hamatus) and two red-blooded notothenioids (Trematomus bernacchii and Gymnodraco acuticeps). We identified substantial remodelling of the haematopoietic programs in the icefish through which erythropoiesis is selectively suppressed. Experimental verification showed that erythropoietic suppression in the icefish may be attributable to the upregulation of TGF-β signalling, which coincides with reductions in multiple transcription factors essential for erythropoiesis and the upregulation of hundreds of microRNAs, the majority (> 80%) of which potentially target erythropoiesis regulating factors. Of the six microRNAs selected for verification, three miRNAs (miR-152, miR-1388 and miR-16b) demonstrated suppressive functions on GATA1 and ALAS2, which are two factors important for erythroid differentiation, resulting in reduced numbers of erythroids in microinjected zebra fish embryos. Codon substitution analyses of the genes of the TGF-β superfamily revealed signs of positive selection in TGF-β1 and endoglin in the lineages leading to Antarctic notothenioids. Both genes are previously known to function in erythropoietic suppression. These findings implied a general trend of erythropoietic suppression in the cold-adapted notothenioid lineages through evolutionary modulation of the multi-functional TGF-β signalling pathway. This trend is more pronounced in the haemoglobin-less icefish, which may pre-emptively hinder the otherwise defective erythroids from production.
Health Care Personnel Time for Anemia Management With Erythropoiesis Stimulating Agents in Hemodialysis Centers in Croatia
ClinicalTrials.gov study NCT02625844. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Evaluate Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) Who Are Hyporesponsive to Erythropoiesis Stimulating Agents
ClinicalTrials.gov study NCT03140722. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Anemia Studies in CKD: Erythropoiesis Via a Novel PHI Daprodustat - Pediatric (ASCEND-P)
ClinicalTrials.gov study NCT05682326. IPD Sharing: YES. Countries: 2. Publications: 0.
Prevalence of Erythropoiesis Stimulating Agents Hyporesponsiveness in Dialysis Patients in Assiut University Hospital
ClinicalTrials.gov study NCT06053866. IPD Sharing: UNDECIDED. Countries: 0. Publications: 8.
Effects Dapagliflozin on Inflammatory Markers Erythropoiesis and Iron Metabolism in Patients with Type 2 Diabetes and CKD
ClinicalTrials.gov study NCT06820567. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Dose-finding Study of Novel Erythropoiesis Stimulating Protein (NESP) for the Treatment of Anaemia in Subjects With Solid Tumours Receiving Multicycle Chemotherapy
ClinicalTrials.gov study NCT00540384. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Study of Roxadustat Conversion in Participants Receiving Stable Erythropoiesis-Stimulating Agent (ESA) or as Initial Anemia Treatment in Chronic Dialysis Participants
ClinicalTrials.gov study NCT04410198. IPD Sharing: NO. Countries: 1. Publications: 0.
Combination of JAK2 Inhibitor and Erythropoiesis-stimulating Agent in Myelofibrosis
ClinicalTrials.gov study NCT03208803. IPD Sharing: NO. Countries: 0. Publications: 7.
Data from: Evolutionary suppression of erythropoiesis via the modulation of TGF-β signaling in an Antarctic icefish
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Global Analysis of the RNA-Protein Interaction and RNA Secondary Structure Landscapes Identifies Dynamic Changes During Mammalian Erythropoiesis (mRNA)
GEO Series GSE148421. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Direct Targets of pSTAT5 signalling in erythropoiesis
GEO Series GSE94301. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Characterization of human erythropoiesis using ex vivo differentiation of CD34 HSC (NG Capture-C)
GEO Series GSE125925. Homo sapiens. 18 samples. Type: Other.
CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis [RNA-seq]
GEO Series GSE281733. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Hydroxymethylation at gene regulatory regions directs stem cell commitment during erythropoiesis
GEO Series GSE40243. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Dynamic control of enhancer repertoires drives lineage and developmental stage-specific transcription during human erythropoiesis
GEO Series GSE70660. Homo sapiens. 30 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Integrated epigenomic and transcriptomic profiling of terminal human erythropoiesis [RNA-seq]
GEO Series GSE115678. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.