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60 results for “Feline”
Complex feline disease mapping using a dense genotyping array
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Feline 63K SNP chip data originated from the domestic cat in Japan
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kendyteng/cat_obsity_attitude: Positive attitudes towards feline obesity are strongly associated with ownership of obese cats
<p>This repository contains the data for the paper: Positive attitudes towards feline obesity are strongly associated with ownership of obese cats</p>
Data from: Feline immunodeficiency virus in puma: estimation of force of infection reveals insights into transmission
Determining parameters that govern pathogen transmission (such as the force of infection, FOI), and pathogen impacts on morbidity and mortality, is exceptionally challenging for wildlife. Vital parameters can vary, for example across host populations, between sexes and within an individual's lifetime. Feline immunodeficiency virus (FIV) is a lentivirus affecting domestic and wild cat species, forming species-specific viral--host associations. FIV infection is common in populations of puma (Puma concolor), yet uncertainty remains over transmission parameters and the significance of FIV infection for puma mortality. In this study the age-specific FOI of FIV in pumas was estimated from prevalence data, and the evidence for disease-associated mortality was assessed. We fitted candidate models to FIV prevalence data and adopted a maximum likelihood method to estimate parameter values in each model. The models with the best fit were determined to infer the most likely FOI curves. We applied this strategy for female and male pumas from southern California, Colorado, and Florida. When splitting the data by sex and area, our FOI modelling revealed no evidence of disease-associated mortality in any population. Both sex and location were found to influence the FOI, which was generally higher for male pumas than for females. For female pumas at all sites, and male pumas from California and Colorado, the FOI did not vary with puma age, implying FIV transmission can happen throughout life; this result supports the idea that transmission can occur from mothers to offspring and also throughout adult life. For Florida males, the FOI was a decreasing function of puma age, indicating an increased risk of infection in the early years, and a decreased risk at older ages. This research provides critical insight into pathogen transmission and impact in a secretive and solitary carnivore. Our findings shed light on the debate on whether FIV causes mortality in wild felids like puma, and our approach may be adopted for other diseases and species. The methodology we present can be used for identifying likely transmission routes of a pathogen and also estimating any disease-associated mortality, both of which can be difficult to establish for wildlife diseases in particular.
On following pages: 10. Angolan Genet (Genetta angolensis); 11. Bourlon's Genet (Genetta bourloni); 12. Crested Genet (Genetta cristata); 13. Feline Genet (Genetta felina), 14. Common Genet (Genetta genetta). in Viverridae
On following pages: 10. Angolan Genet (Genetta angolensis); 11. Bourlon's Genet (Genetta bourloni); 12. Crested Genet (Genetta cristata); 13. Feline Genet (Genetta felina), 14. Common Genet (Genetta genetta).
The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-β1
<p>Chronic kidney disease (CKD) is common in both geriatric cats and aging humans, and is pathologically characterised by chronic tubulointerstitial inflammation and fibrosis in both species. Cats with CKD may represent a spontaneously occurring, non-rodent animal model of human disease, however little is known of feline renal cell biology. In other species, TGF-β1 signalling in the proximal tubular epithelium is thought to play a key role in the initiation and progression of renal fibrosis. In this study, we first aimed to isolate and characterise feline proximal tubular epithelial cells (FPTEC), comparing them to human primary renal epithelial cells (HREC) and the human proximal tubular cell line HK-2. Secondly, we aimed to examine and compare the effect of human recombinant TGF-β1 on cell proliferation, pro-apoptotic signalling and genes associated with epithelial-to-mesenchymal transition (EMT) in feline and human renal epithelial cells.</p> <p>FPTEC were successfully isolated from cadaverous feline renal tissue, and demonstrated a marker protein expression profile identical to that of HREC and HK-2. Exposure to TGF-β1 (0-10 ng/ml) induced a concentration-dependent loss of epithelial morphology and alterations in gene expression consistent with the occurrence of partial EMT in all cell types. This was associated with transcription of downstream pro-fibrotic mediators, growth arrest in FPTEC and HREC (but not HK-2), and increased apoptotic signalling at high concentrations of TGF- β1. These effects were inhibited by the ALK5 (TGF-β1RI) antagonist SB431542 (5 µM), suggesting they are mediated via the ALK5/TGF-β1RII receptor complex. Taken together, these results suggest that TGF-β1 may be involved in epithelial cell dedifferentiation, growth arrest and apoptosis in feline CKD as in human disease, and that cats may be a useful, naturally occurring model of human CKD.</p>
Supplementary documents for Decitabine Increases the Transcription of RIG-I Gene to Sup-press the Replication of Feline Calicivirus and Canine Influen-za Virus
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Fig. 5 in Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Fig. 5. Feline calicivirus (FCV)-inactivating activities of Dracocephalum spp.-derived compounds. Compounds isolated from D. fruticulosum (A and B), D. nutans (C and D), and D. foetidum (E and F) were incubated with FCV suspensions for 48 h (A, C, and E) and 6 h (B, D, and F), respectively. Viral titer data are presented as the mean ± standard deviation (n = 3–7 per group). *p <0.05; **p <0.01 vs. the dimethyl sulfoxide (DMSO) control group (Student's t-test). TCID50, 50% tissue culture infectious dose.
Fig. 4 in Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Fig. 4. Key heteronuclear multiple bonds (HMBC) and nuclear Overhauser effect (NOE) correlations of compounds 19–21.
Data from: Feline immunodeficiency virus in puma: estimation of force of infection reveals insights into transmission
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Characterization of Neutrophil Functional Responses to SARS-CoV-2 Infection in a Translational Feline Model for COVID-19
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Fig. 2 in Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Fig. 2. Key heteronuclear multiple bond (HMBC) correlations of compound 1.
Fig. 3 in Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Fig. 3. Electronic CD spectra of compounds 1 and 5.
Fig. 1 in Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Fig. 1. Structures of compounds 1–21.
Human and feline adipose-derived mesenchymal stem cells have comparable immunomodulatory functions
GEO Series GSE94773. Felis catus. 3 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome Profiling sequencing analysis of feline ovarian granulosa cell treated with Atractylenolide Ⅰ
GEO Series GSE155784. Felis catus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic signatures of feline chronic gingivostomatitis are influenced by upregulated IL6
GEO Series GSE230491. Felis catus. 29 samples. Type: Expression profiling by high throughput sequencing.
The transcriptomic and proteomic landscape of feline fibrosarcoma and matched normal tissue
GEO Series GSE275872. Felis catus. 77 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of feline chronic gingivostomatitis (FCGS)
GEO Series GSE149881. Felis catus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis reveals a critical role for activating Gsα mutations in spontaneous feline hyperthyroidism
GEO Series GSE276271. Felis catus. 15 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.