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1,772 results for “Gels”
Dataset for publication "Sol-gel derived silicate-phosphate glass SiO2–P2O5–CaO–TiO2: the effect of titanium isopropoxide on porosity and thermomechanical stability"
<p>In this work, sol-gel silica-phosphate glasses (30 mol.% P<sub>2</sub>O<sub>5</sub>) with defined porosity from 2.5 to 7.5 mol.% TiO<sub>2</sub> modifications were synthesized. Thee dimensional stability with respect to the thermal stability of porous silica-phosphate glasses modified by titanium dioxide (TiO<sub>2</sub>) through titanium isopropoxide (TTIP) precursor was studied.</p> <p>The data of thermomechanical and thermogravimetric analysis, X-ray diffraction, SEM -EDX, mercury intrusion porosimetry, N2 physisorption, micro-computed tomography, ultra-small-angle X-ray scattering are published.</p>
Segmented Gel Electrophoresis Images used for Training GelGenie Models
<p>This repository contains gel images and corresponding hand-labelled segmentation maps (575 total) from various sources. The images have various sizes, shapes, gel contents and imaging conditions. In more detail:</p> <ul> <li>The matthew_gels (301 total), matthew_gels_2 (85 total) and nathan_gels (37 total) folders contain images originating from previous experiments in the Dunn Lab. </li> <li>The quantitation_ladder_gels (35 total) were generated specifically for the GelGenie project and contain gel ladders in each well. These were used to generate the data for Figure 1 in the main paper.</li> <li>The stella_gels_for_finetuning (26 total) folder contains gel images provided to us from Siyuan Stella Wang (Wyss Institute/Dana-Farber Cancer Institute) which we used to finetune our U-Net model and produce the results in Figure 4C of the main paper.</li> <li>The external_gels (25 total) images were gifted to us from 5 different researchers: Yichen Zhao (images generated at the University of Waterloo), Huangchen Cui (images generated at Tsinghua University), Thomas Mayer (images generated at the Technical University of Munich), Joana Reis (images generated at the Dana-Farber Cancer Institute) and Ricarda Törner (images generated at the Dana-Farber Cancer Institute). These were used as an external unseen test set for our fine-tuned model.</li> <li>The lsdb_gels (66 total) folder contains segmentation maps of images downloaded from the RGB Caps dataset, which is available from https://dbarchive.biosciencedbc.jp/en/rgp-caps/desc.html. The original images have been shared with a Creative Commons Attribution-Share Alike 2.1 Japan license. Permission was obtained from the data depositors for the training of our models on these images, as well as for the sharing of derived segmentation masks using the CC-BY license. To use this portion of the dataset, you will need to download the original images from the website, and place them alongside our segmentation masks, mirroring the same setup used for all the other datasets in this repository.</li> </ul> <p>The folders are organised as follows:</p> <ul> <li>The images, val_images and test_images contain the original images, split into training/validation/testing partitions respectively (except for the lsdb_gels dataset).</li> <li>The masks, val_masks and test_masks contain the corresponding segmentation maps for each image in the main folders (they have identical naming i.e. an image named test_image.tif will have a segmentation map labelled test_image.tif).</li> <li>The external_gels folder does not have validation or test partitions.</li> </ul> <p>The segmentation maps are 8-bit images, for which a white pixel (0) corresponds to a background pixel and a brown pixel (1) corresponds to a foreground pixel.</p> <p>This is the main dataset used to train the GelGenie models, for which the corresponding source code and GUI can be downloaded at https://github.com/mattaq31/GelGenie.</p>
Dataset: Glass-forming ability and structural features of melt-quenched and gel-derived SiO2-TiO2 glasses
<p>Research data for Manuscript submission with title</p> <p><strong>Glass-forming ability and structural features of melt-quenched and gel-derived SiO<sub>2</sub>-TiO<sub>2</sub> glasses</strong></p> <p><strong>Abstract</strong></p> <p>SiO<sub>2</sub>-TiO<sub>2 </sub>glasses produced by melt-quenching or sol-gel spray-drying were compared to highlight their structural differences. Glass formation was possible by melt-quenching up to 10 mol% TiO<sub>2</sub>, while higher contents led to devitrification. Raman spectroscopy and solid-state <sup>17</sup>O and <sup>29</sup>Si MAS NMR confirmed the clear emergence of Ti-O-Si bonds and a tetrahedral oxygen coordination of Ti<sup>4+</sup> leading to full network connectivity, as also substantiated by the synthesis of TiO<sub>2</sub>-doped cristobalite. In gel-derived glasses, water content induced partial network depolymerization, thereby enhancing the solubility of TiO<sub>2</sub> in the hydrous silicate matrix. However, full dehydration during heating proved challenging due to the competing devitrification tendency: the glass-forming range in the anhydrous binary SiO<sub>2</sub>-TiO<sub>2</sub> system does not therefore appear to be significantly enlarged by the sol-gel synthesis route.</p>
A representative gel of ALAD following a restriction fragment length digestion
<p><span><strong>Background</strong>:</span><span> Rapid industrialization, urbanization, and population explosion in sub-Saharan Africa escalate environmental lead levels and subsequently blood lead levels in children. Its levels in one's environment account for his/her blood lead levels. One's susceptibility to lead toxicity is governed by his/her nutrition status, age and genetics. This study aimed at expounding susceptibility to lead toxicity by relating blood lead levels, delta-aminolevulinic acid dehydratase (ALAD) enzyme activity, and genetic variations of proteins that code for ALAD in urban children of Uganda.</span></p> <p><span><strong>Methods</strong>: </span><span>A total of 198 blood samples were spectrophotometrically analyzed for blood lead levels (BLL), hemoglobin (Hb) levels, and ALAD enzyme activity before DNA extraction, polymerase chain reaction, and restriction fragment length digestion for ALAD polymorphism. </span></p> <p><span><strong>Results</strong>: </span><span>Up to 99.5% of the total samples analysed coded for ALAD1 allele compared to 0.05% that coded for ALAD2. There was a significant relationship between BLL, Hb status and ALAD enzyme activity in the three isozymes (ALAD1-1, ALAD1-2 and ALAD2-2) in strength of ALAD1-1 (r = 0.42, p-value = 0.02) ˂ALAD1-2 (r = 0.62, p-value = ˂0.001) ˂ ALAD2-2 (r = 0.67, p-value = ˂0.001).</span></p> <p><span><strong>Conclusions</strong>: </span><span>The majority of children in Uganda code for the ALAD1 allele, which is important for blood lead ions hoarding during lead toxicity. Hoarding of blood lead not only delays exposure effects but also accumulates its levels in deposit tissues and this poses adverse effects later in their lives.</span></p>
Macrophage targeting of nitazoxanide-loaded transethosomal gel in cutaneous leishmaniasis
<p>Topical delivery is preferable over systemic delivery for cutaneous leishmaniasis (CL), because of its easy administration, reduced systemic adverse effects, and low cost. Nitazoxanide (NTZ) has broad-spectrum activity against various parasites and has the potential to avoid drug resistance developed by enzymatic mutations. NTZ oral formulation is being associated with severe dyspepsia and stomach pain. Herein, NTZ-transethosomes (NTZ-TES) were prepared and loaded into chitosan gel (NTZ-TEG) for topical delivery. NTZ-TES were prepared by thin-film-hydration method and optimized statistically via Box-Behnken method. The optimized formulation indicated excellent particle size (176 nm), PDI (0.093), zeta potential (-26.4 mV) and entrapment efficiency (EE, 86%). The TEM analysis showed spherical sized particles and FTIR analysis indicated no interaction among the excipients. Similarly, NTZ-TEG showed optimal pH, desirable viscosity and good spreadability. NTZ-TES and NTZ-TEG showed prolonged release behavior and higher skin penetration and deposition in epidermal/dermal layer of skin in comparison with the NTZ-dispersion. Moreover, NTZ-TES showed higher percentage inhibition, lower IC50 against promastigotes and higher macrophage uptake. Additionally, skin irritation and histopathology studies indicated the safe and non-irritant behavior of the NTZ-TEG. The obtained findings suggested the enhanced skin permeation and improved anti-leishmanial effect of NTZ when administered as NTZ-TEG.</p>
Data for 'From Gel to Crystal: Mechanism of HfO2 and ZrO2 Nanocrystal Synthesis in Benzyl Alcohol'
<p>Data of the figures in the publication "<strong>From Gel to Crystal: Mechanism of HfO<sub>2</sub> and ZrO<sub>2</sub> Nanocrystal Synthesis in Benzyl Alcohol</strong>".</p> <p>The <em>.pxp</em> documents contain the experimental data of the figures in the manuscript and they can be opened/edited with the software IGOR Pro 6.3 or higher.</p> <p>Table of contents:</p> <p><strong>Figure 1.</strong> (A) Microwave-assisted solvothermal synthesis of HfO<sub>2</sub> nanocrystals starting from HfCl<sub>4</sub>·2THF in benzyl alcohol. (B) XRD spectrum (black) with a monoclinic reference spectrum (blue, Crystallographic Open Database ID 9013470). (C) Pictures of the upside down microwave tube, stopped at different time points in the reaction to indicate the disappearance of the gel over time. (D) TEM image of the synthesized NCs shows their ellipsoidal shape. The size distribution and a zoom of a single NC are shown in the top and bottom left corner, respectively. (E) The rapid increase in storage modulus <em>G</em>′ and loss modulus <em>G</em>″ over time (average of 3 measurements) indicates the point where the solution turns into a gel. (F) Storage modulus <em>G</em>′ and loss modulus <em>G</em>″ of the gel after repeatedly (three cycles) applying 10% (stress) and 1% (recovery) shear stress (γ) at 25 °C and (G) at 160 °C.</p> <p><strong>Figure 2.</strong> (A) Titration of HfCl<sub>4</sub>·2THF with benzyl alcohol in the presence of TOPO in C<sub>6</sub>D<sub>6</sub>, followed via <sup>31</sup>P NMR. The spectra have a relative <em>x</em>-offset of 1 ppm with respect to each other for clarity. (B) Coordination numbers of chloride and oxygen surrounding the hafnium center, calculated from the EXAFS data. (C) Hf–O distance contraction at increasing temperature. The octahedral of the HfCl<sub>3</sub>OBn·2THF structure is shown for clarity.</p> <p><strong>Figure 3. </strong>(A) <sup>1</sup>H NMR assignment of the resonances in the supernatant between 4.4 and 4.8 ppm. The full width at half-maximum (in Hz) of the benzyl alcohol peak is indicated and decreases with increasing temperature. (B) Equivalents of benzyl alcohol, dibenzyl ether, and benzyl chloride with respect to hafnium (taking into account other side products present) in the reaction supernatant at increasing temperature. The amount of water is calculated based on the amount of dibenzyl ether and benzyl chloride detected.</p> <p><strong>Figure 4. </strong>(A) <em>In situ</em> total scattering data showing <em>G</em>(<em>r</em>) as a function of time. Dashed lines indicate when temperature is increased. Selected PDFs from the intermediate and the final stage of the reaction are plotted. (B) PDF of the precursor structure with major peaks assigned and in comparison to simulated PDFs based on the possible precursor structures. Fit of the PDF data of (C) the intermediate gel, collected after 9 min of reaction at 150 °C, and (D) the final product to m-HfO<sub>2</sub>, collected after 81 min of total reaction time. (E) Refined crystallite size and scale factor as a function of time. (F) TEM image of a sample after 3 min at 220 °C. The size distribution (25 particles) and zoom of a single NC are shown in the top and bottom left corner, respectively.</p> <p><strong>Figure 5. </strong>Isolated particle yield of HfO<sub>2</sub> NC syntheses run for different reaction times. The yield can be significantly improved at only 1 h by adding water postsynthesis. Each reaction is performed in triplicate, and yield is determined gravimetrically.</p>
Data for: Bioinspired Lubricity from Surface Gel Layers
<p>Surface gel layers on commercially-available contact lenses have been shown to reduce frictional shear stresses and mitigate damage during sliding contact with fragile epithelial cell layers <em>in vitro</em>. Spencer and coworkers recently demonstrated that surface gel layers could arise by polymerizing hydrogels within molds composed of low surface energy materials and near oxygen-rich interfaces from peroxidation gradients. In this study, polyacrylamide hydrogel shell probes (7.5 wt.% polyacrylamide, 0.3 wt.% methylenebisacrylamide) were polymerized in three hemispherical molds listed in order of decreasing surface energy and increasing oxygen permeability: borosilicate glass, polyetheretherketone (PEEK), and polytetrafluoroethylene (PTFE). Hydrogel probes polymerized in PEEK and PTFE molds exhibited 100´ lower elastic moduli at the surface (<em>E*<sub>PEEK </sub></em>= 80 ± 31 Pa and <em>E*<sub>PTFE</sub></em><sub> </sub>= 106 ± 26 Pa, respectively) than those polymerized in glass molds (<em>E*<sub>glass</sub></em><sub> </sub>= 31,560 ± 1,570 Pa), in agreement with previous investigations by Spencer and coworkers. Biotribological experiments revealed that hydrogel probes with surface gel layers reduced frictional shear stresses against cells (<em><em>τ</em><sub>PEEK</sub></em> = 35 ± 15 Pa and <em>τ<sub>PTFE</sub></em> = 22 ± 16 Pa) more than those without (<em>τ</em><em><sub>glass</sub></em> = 68 ± 15 Pa) and offered greater protection against cell damage when sliding against human telomerase-immortalized corneal epithelial (hTCEpi) cell monolayers. Our work demonstrates that the "mold effect" resulting in oxygen-inhibition polymerization creates hydrogels with surface gel layers that reduce shear stresses in sliding contact with cell monolayers, similar to the protection offered by gradient mucin gel networks across epithelial cell layers.</p>
Figure 1 in Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies
Figure 1. pH analysis for cosmetics in cream and gel base.
Figure 2 in Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies
Figure 2. Color analysis for cosmetics in cream and gel base.
Figure 5 in Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies
Figure 5. Wavelength analysis for cosmetics in cream and gel base.
TECdisplay validation gel images
<p>Gel images collected during development of the Transcription Elongation Complex Display (TECdisplay) method to validate the RNA-dependent DNA fractionation strategy and deoxyuridine excision tagging optimizations.</p>
TECprobe-LM validation gel images
<p>Gel images collected during development of the linked multipoint Transcription Elongation Complex RNA structure probing (TECprobe-LM) method to assess the transcription roadblocking configurations that were used to capture RNA folding intermediates.</p>
Data for the publication: Advancing Reversible Magnesium−Sulfur Batteries with a Self-Standing Gel Polymer Electrolyte
<p>This is a collection featuring the data generated and used within the paper: "Advancing Reversible Magnesium−Sulfur Batteries with a Self-Standing Gel Polymer Electrolyte"</p>
DNA Stack Data Structure: Data Set of Polyacrylamide Gels
<p>Data set to accompany paper: A Last-In First-Out Stack Data Structure Implemented in DNA, Lopiccolo and Shirt-Ediss et al., Nature Comms 12, 4861 (2021). <a href="https://doi.org/10.1038/s41467-021-25023-6">doi:10.1038/s41467-021-25023-6</a>.</p> <p>The data set contains 32 polyacrylamide gel experiments (reaction sequences and gel images) used for creating the electrophoretic mobility graph in Figure S13 of the SI of the above paper.</p>
Rat tooth extraction and 3% binahong (Anredera cordifolia (Ten.) STEENIS) leaf extract gel
<p>The following photos are related to the research entitled "The effects of 3% binahong (Anredera cordifolia) leaf extract gel on the alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus)"</p>
The hidden hierarchical nature of soft particulate gels
<p>This dataset contains data for the manuscript "The hidden hierarchical nature of soft particulate gels".</p>
Videos: The crystallization mechanism of gel-derived SiO2-TiO2 amorphous nanobeads elucidated by high-temperature in-situ experiments
<p>Supplementary materials detailing high-temperature in-situ TEM experiments.</p> <p>Main article available at: <a href="https://doi.org/10.1021/acs.cgd.3c00300">https://doi.org/10.1021/acs.cgd.3c00300</a></p> <p> </p>
Trial to Assess the Impact of PrEP to Tenofovir Gel on the Efficacy of Tenofovir-containing ART on Viral Suppression
ClinicalTrials.gov study NCT01387022. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Benzac 5% Gel in Combination With Cosmetic Products in Acne Vulgaris
ClinicalTrials.gov study NCT02589405. IPD Sharing: Not stated. Countries: 1. Publications: 1.
LEO 90100 Aerosol Foam Compared to Calcipotriol Plus Betamethasone Dipropionate Gel in Subjects With Psoriasis Vulgaris
ClinicalTrials.gov study NCT02132936. IPD Sharing: NO. Countries: 1. Publications: 4.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.