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211
datasets available to search
ShareScore release 0.9.0
Dataset results
211 results for “Genetic screens”
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)
ClinicalTrials.gov study NCT02194738. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Preimplantation Genetic Screening in IVF Treatment
ClinicalTrials.gov study NCT05009745. IPD Sharing: YES. Countries: 1. Publications: 1.
ScreenIng of Genetic Susceptibility Genes for Breast Cancer Patients in CHinese communiTies
ClinicalTrials.gov study NCT04265937. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
ClinicalTrials.gov study NCT02465060. IPD Sharing: Not stated. Countries: 3. Publications: 13.
Investigating the Cryopreserved Blastocyst's ImplantatiOn Potential After Genetic Screening
ClinicalTrials.gov study NCT03173885. IPD Sharing: NO. Countries: 1. Publications: 1.
Genetic Newborn Screening for Cystinosis and Primary Hyperoxaluria
ClinicalTrials.gov study NCT05843851. IPD Sharing: NO. Countries: 1. Publications: 10.
The Signal-Trial: Evaluation of a Screening Tool for Psychosocial Problems in Cancer Genetics
ClinicalTrials.gov study NCT01562431. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Utility Of Genetic Screening For HLA-B*5701, On Susceptibility To Abacavir Hypersensitivity
ClinicalTrials.gov study NCT00340080. IPD Sharing: Not stated. Countries: 19. Publications: 1.
Screening and Genetic Monitoring of Patients With Myelodysplastic Syndromes (MDS) Under Different Treatment Modalities by Cytogenetic Analyses of Circulating CD34+Cells
ClinicalTrials.gov study NCT01355913. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Cumulative Live Birth Rate With eSET After Preimplantation Genetic Screening Versus Conventional In-vitro Fertilization
ClinicalTrials.gov study NCT03118141. IPD Sharing: UNDECIDED. Countries: 1. Publications: 12.
Genetic Epidemiology Risk Assessment Program or Usual Care in Colorectal Cancer Screening for Healthy Participants
ClinicalTrials.gov study NCT00478309. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Genetic Risk-Based Atrial Fibrillation Screening (GeneAF Study)
ClinicalTrials.gov study NCT04932798. IPD Sharing: NO. Countries: 1. Publications: 3.
Is Family Screening Improved by Genetic Testing of Familial Hypercholesterolemia
ClinicalTrials.gov study NCT04526457. IPD Sharing: NO. Countries: 0. Publications: 15.
Genetic Newborn Screening for Rare Diseases Within the Screen4Care Project
ClinicalTrials.gov study NCT06549218. IPD Sharing: NO. Countries: 3. Publications: 0.
Removal of the Ovaries/Fallopian Tubes and CA-125 Screening to Reduce the Risk of Ovarian Cancer in Women at Increased Genetic Risk
ClinicalTrials.gov study NCT00043472. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk
ClinicalTrials.gov study NCT02478892. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Adaptive Clinical Trial of BeginNGS Newborn Screening for Hundreds of Genetic Diseases by Genome Sequencing
ClinicalTrials.gov study NCT06306521. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis
Somatic cell genetics is a powerful approach for unraveling the regulatory mechanism of cholesterol metabolism. However, it is difficult to identify the mutant gene(s) due to cells are usually mutagenized chemically or physically. To identify important genes controlling cholesterol biosynthesis, an unbiased forward genetics approach named validation-based insertional mutagenesis (VBIM) system was used to isolate and characterize the 25-hydroxycholesterol (25-HC)-resistant and SR-12813-resisitant mutants. Here we report that five mutant cell lines were isolated. Among which, four sterol-resistant mutants either contain a truncated NH2-terminal domain of sterol regulatory element-binding protein (SREBP)-2 terminating at amino acids (aa) 400, or harbor an overexpressed SREBP cleavage-activating protein (SCAP). Besides, one SR-12813 resistant mutant was identified to contain a truncated COOH-terminal catalytic domain of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase). This study demonstrates that the VBIM system can be a powerful tool to screen novel regulatory genes in cholesterol biosynthesis.
Data from: The conditional nature of genetic interactions: the consequences of wild-type backgrounds on mutational interactions in a genome-wide modifier screen
The phenotypic outcome of a mutation cannot be simply mapped onto the underlying DNA variant. Instead, the phenotype is a function of the allele, the genetic background in which it occurs and the environment where the mutational effects are expressed. While the influence of genetic background on the expressivity of individual mutations is recognized, its consequences on the interactions between genes, or the genetic network they form, is largely unknown. The description of genetic networks is essential for much of biology; yet if, and how, the topologies of such networks are influenced by background is unknown. Furthermore, a comprehensive examination of the background dependent nature of genetic interactions may lead to identification of novel modifiers of biological processes. Previous work in Drosophila melanogaster demonstrated that wild-type genetic background influences the effects of an allele of scalloped (sd), with respect to both its principal consequence on wing development and its interactions with a mutation in optomotor blind. In this study we address whether the background dependence of mutational interactions is a general property of genetic systems by performing a genome wide dominant modifier screen of the sdE3 allele in two wild-type genetic backgrounds using molecularly defined deletions. We demonstrate that ~74% of all modifiers of the sdE3 phenotype are background-dependent due in part to differential sensitivity to genetic perturbation. These background dependent interactions include some with qualitative differences in the phenotypic outcome, as well as instances of sign epistasis. This suggests that genetic interactions are often contingent on genetic background, with flexibility in genetic networks due to segregating variation in populations. Such background dependent effects can substantially alter conclusions about how genes influence biological processes, the potential for genetic screens in alternative wild-type backgrounds identifying new loci that contribute to trait expression, and the inferences of the topology of genetic networks.
Retrospective Study on Clinical Results of Preimplantation Genetic Screening at Different Embryo Stage
ClinicalTrials.gov study NCT03065114. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.