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201
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Dataset results
201 results for “Glutamate”
Does Enhanced Glutamate Transporter Function Produce Antidepressant Effects in People With Major Depression?
ClinicalTrials.gov study NCT02049385. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Glutamate for Metabolic Intervention in Coronary Surgery II
ClinicalTrials.gov study NCT02592824. IPD Sharing: Not stated. Countries: 1. Publications: 36.
Research Study for Major Depressive Disorder: Investigation of Glutamate Medications
ClinicalTrials.gov study NCT00419003. IPD Sharing: NO. Countries: 1. Publications: 3.
Data from: Effects of fluorescent glutamate indicators on neurotransmitter diffusion and uptake
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Characterization of postsynaptic glutamate transporter functionality in the zebrafish retinal first synapse across different wavelengths
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Nanoelectrochemistry reveals how soluble Aβ42 oligomers alter vesicular storage and release of glutamate
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Data from: Glutamate sensor and calcium signals in dopamine neurons and dopamine release
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Data from: Bidirectional dysregulation of synaptic glutamate signaling after transient metabolic failure
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Influence of Volatile Anesthesia on the Release of Glutamate and other Amino Acids in the Nucleus Accumbens of Alcohol-Withdrawn Rats
<p>An alcohol withdrawal syndrome is a potentially life-threatening condition, which may occur when patients with alcohol use disorders have to undergo general anesthesia. Excitatory amino acids, such as glutamate, act as neurotransmitters and play a key role in alcohol withdrawal. We investigated the influence of isoflurane, sevoflurane, and desflurane anesthesia on the profile of excitatory and inhibitory amino acids in the Nucleus accumbens (NAcc) of alcohol-withdrawn rats (AWR).</p> <p>80 Wistar rats were randomized into two groups of 40, pair-fed with alcoholic or non-alcoholic nutrition. Nutrition was withdrawn and microdialysis trials were performed to measure the activity of amino acids in the NAcc. The withdrawal onset time was determined in a first trial with 20 rats. 60 rats then received isoflurane, sevoflurane, or desflurane anesthesia for three hours during withdrawal period, followed by one hour of elimination. Amino acid concentrations were obtained by chromatography. Quantification was done by integration and analysis of the area under the curve (AUC).</p>
Influence of Volatile Anesthesia on the Release of Glutamate and other Amino Acids in the Nucleus Accumbens of Alcohol-Withdrawn Rats
<p>An alcohol withdrawal syndrome is a potentially life-threatening condition, which may occur when patients with alcohol use disorders have to undergo general anesthesia. Excitatory amino acids, such as glutamate, act as neurotransmitters and play a key role in alcohol withdrawal. We investigated the influence of isoflurane, sevoflurane, and desflurane anesthesia on the profile of excitatory and inhibitory amino acids in the Nucleus accumbens (NAcc) of alcohol-withdrawn rats (AWR).</p> <p>80 Wistar rats were randomized into two groups of 40, pair-fed with alcoholic or non-alcoholic nutrition. Nutrition was withdrawn and microdialysis trials were performed to measure the activity of amino acids in the NAcc. The withdrawal onset time was determined in a first trial with 20 rats. 60 rats then received isoflurane, sevoflurane, or desflurane anesthesia for three hours during withdrawal period, followed by one hour of elimination. Amino acid concentrations were obtained by chromatography. Quantification was done by integration and analysis of the area under the curve (AUC).</p>
Data for: Engineering A-type Dye-decolorizing Peroxidases by Modification of a Conserved Glutamate Residue
<p><span>Dye-decolorizing peroxidases (DyPs) are recently identified microbial enzymes that have been used in several Biotechnology applications from wastewater treatment to lignin valorization. However, their properties and mechanism of action still have many open questions. Their heme-containing active site is buried by three conserved flexible loops with a putative role in modulating substrate access and enzyme catalysis. Here, we investigated the role of a conserved glutamate residue in stabilizing interactions in loop 2 of A-type DyPs. First, we did site saturation mutagenesis of this residue, replacing it with all possible amino acids in bacterial DyPs from Bacillus subtilis (BsDyP) and from Kitasatospora aureofaciens (KaDyP1), the latter being characterized here for the first time. We screened the resulting libraries of variants for activity towards ABTS and identified variants with increased catalytic efficiency. The selected variants were purified and characterized for activity and stability. We furthermore used Molecular Dynamics simulations to rationalize the increased catalytic efficiency and found that the main reason is the electron channeling becoming easier from surface-exposed tryptophans. Based on our findings, we also propose that this glutamate could work as a pH switch in the wild-type enzyme, preventing intracellular damage. </span></p>
Identification and prioritization of novel therapeutic candidates against Glutamate racemase from Klebsiella pneumoniae
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Transient Na+-binding site is essential for transport mechanism in the glutamate transporter homologue GltTk
<p>Dataset to reproduce MD simulations described in "Transient Na+-binding site is essential for transport mechanism in the glutamate transporter homologue GltTk".</p>
Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6
<p>Dataset to reproduce MD simulations described in "New insights into a mutation leading to episodic ataxia 6"</p>
Data underlying the article: Molecular insights into disease-associated glutamate transporter (EAAT1 / SLC1A3) variants using in silico
<p>This repository contains the scripts and data for the project published in Frontiers in Molecular Biosciences under the title:<strong> Molecular insights into disease-associated glutamate transporter (EAAT1 / SLC1A3) variants using in silico and in vitro approaches</strong> (DOI <a href="https://www.frontiersin.org/articles/10.3389/fmolb.2023.1286673/full">10.3389/fmolb.2023.1286673</a>). </p>
Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls
<p>This link contains the Data Source files, the code, and raw MRS data analysed in <a href="https://www.researchsquare.com/article/rs-2152573/v1">this article</a>. </p>
Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine
ClinicalTrials.gov study NCT04977674. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Safety Study of PGA (Poly-gamma Glutamic Acid) for Cervical Intraepithelial Neoplasia
ClinicalTrials.gov study NCT01826045. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine and Cyanocobalamin as Therapy for Vertigo
ClinicalTrials.gov study NCT05221892. IPD Sharing: NO. Countries: 1. Publications: 10.
Altered Brain GABA and Glutamate in Restless Legs Syndrome
ClinicalTrials.gov study NCT01109537. IPD Sharing: Not stated. Countries: 1. Publications: 8.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.