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59 results for “HSP70”
ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (E18.5 femur and tibia)
GEO Series GSE210511. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT
GEO Series GSE114882. Saccharomyces cerevisiae. 22 samples. Type: Other.
Profiling Ssb-Nascent Chain Interactions Reveals Principles of Hsp70-Assisted Folding
GEO Series GSE93830. Saccharomyces cerevisiae. 40 samples. Type: Other.
Proteostasis perturbation of N-Myc by HSP70 inhibition improves treatment in neuroendocrine prostate cancer II
GEO Series GSE249917. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Next Generation Sequencing Facilitates Quantitative Analysis of Tg(hsp70:dn-xBrg1) and wild-type sibling hearts Transcriptomes
GEO Series GSE81627. Danio rerio. 4 samples. Type: Expression profiling by high throughput sequencing.
ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (primary cells)
GEO Series GSE210796. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
HSP70-driven molecular response to the proteasome machinery inhibition is a vulnerability in cancer
GEO Series GSE184029. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Hsp70-Bim interaction mediated mitophagy as a potential therapeutic target for CML stem cells
GEO Series GSE311089. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (proximal tibia srRNASeq)
GEO Series GSE210637. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
circ_0000045 promotes proliferation, migration, and invasion of head and neck squamous cell carcinomas via binding with HSP70 and MAPK signaling activation
GEO Series GSE197138. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Mechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery
GEO Series GSE305556. Escherichia coli str. K-12 substr. MG1655. 12 samples. Type: Other.
Transcriptional response to the HSP70 inhibitor MAL3-101 in parental rhabdomyosarcoma cells and isogenic acquired-resistance lines.
GEO Series GSE80525. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Hikeshi-Mediated Nuclear Translocation of HSP70 Promotes Myelinogenesis by Preventing FBXW7-mediated Degradation of Sox10
GEO Series GSE225577. Rattus norvegicus. 2 samples. Type: Expression profiling by high throughput sequencing.
Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2a via the Hsp70-Bag3 module.
GEO Series GSE171440. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Data from: Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding
Survival of trophoblast cells in the low oxygen environment of human placentation requires metalloproteinase-mediated shedding of HBEGF and downstream signaling. A matrix metalloproteinase (MMP) antibody array and quantitative RT-PCR revealed upregulation of MMP2 post-transcriptionally in human first trimester HTR-8/SVneo trophoblast cells and placental villous explants exposed to 2% O2. Specific MMP inhibitors established the requirement for MMP2 in HBEGF shedding and upregulation. Because α-amanitin inhibited the upregulation of HBEGF, differentially expressed genes were identified by next-generation sequencing of RNA from trophoblast cells cultured at 2% O2 for 0, 1, 2 and 4 h. Nine genes, all containing HIF-response elements, were upregulated at 1 h, but only HSPA6 (HSP70B') remained elevated at 2–4 h. The HSP70 chaperone inhibitor VER 155008 blocked upregulation of both MMP2 and HBEGF at 2% O2, and increased apoptosis. However, both HBEGF upregulation and apoptosis were rescued by exogenous MMP2. Proximity ligation assays demonstrated interactions between HSP70 and MMP2, and between MMP2 and HBEGF, supporting the concept that MMP2-mediated shedding of HBEGF, initiated by HSP70, contributes to trophoblast survival at the low O2 concentrations encountered during the first trimester, and is essential for successful pregnancy outcomes. Trophoblast survival during human placentation, when oxygenation is minimal, required HSP70 activity, which mediated MMP2 accumulation and the transactivation of anti-apoptotic ERBB signaling by HBEGF shedding.
Assessing the Effects of Omega-3 Supplementation on Serum HSP27, HSP70, YKL40, BMP-4 Levels in Male Patient With CAD
ClinicalTrials.gov study NCT02117960. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Propofol and Sevoflurane Anesthesia on HSP70 Expression in Tumor Cells
ClinicalTrials.gov study NCT06626711. IPD Sharing: YES. Countries: 1. Publications: 0.
Study Using Vaccination With Heat Shock Protein 70 (HSP70) for the Treatment of CML in Chronic Phase
ClinicalTrials.gov study NCT00027144. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Knockout of Hsp70 genes significantly affects locomotion speed and gene expression in leg skeletal muscles of Drosophila melanogaster
GEO Series GSE239395. Drosophila melanogaster. 40 samples. Type: Expression profiling by high throughput sequencing.
Data from: Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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