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Dataset results
151 results for “High throughput screening”
C.Origami: Cell type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening
<p>This data repository includes dataset generated from IMR-90, GM12878 cell lines and C.Origami pre-trained model weights.</p> <p>GitHub page: https://github.com/tanjimin/C.Origami</p>
Resources and datasets for automated high-throughput droplet screening by iSort
<p>Contains the design files and source data linked to the following publication in Cell Reports Methods (2023, https://doi.org/10.1016/j.crmeth.2023.100478)</p> <p><strong><em>iSort </em></strong><strong>enables automated complex microfluidic droplet sorting in an effort to democratize technology.</strong></p> <p><strong>Abstract: </strong><br> Fluorescence activated droplet sorting (FADS) is a widely used microfluidic technique for high throughput screening. However, it requires highly trained specialists to determine optimal sorting parameters, resulting in a large combinatorial space that is challenging to optimize systematically. Additionally, there is currently no way to track every single droplet within a screen, leading to compromised sorting and “hidden” false positive events. To overcome all these limitations, we have developed a setup in which the droplet frequency, spacing and trajectory at the sorting junction are monitored in real time using impedance analysis. The resulting data is used to continuously optimize all parameters automatically and to counteract perturbations, resulting in higher throughput, higher reproducibility, increased robustness and a beginner-friendly character. We believe this provides a missing piece for the spreading of phenotypic single-cell analysis methods, similar to what we have seen for single-cell genomics platforms.</p> <p><strong>To cite:</strong> https://doi.org/10.1016/j.crmeth.2023.100478</p>
Selecting Chemotherapy With High-throughput Drug Screen Assay Using Patient Derived Organoids in Patients With Refractory Solid Tumours (SCORE)
ClinicalTrials.gov study NCT04279509. IPD Sharing: NO. Countries: 1. Publications: 2.
High-throughput screen to identify and optimize NOT gate receptors for cell therapy
Open the record for dataset details and reuse information.
Data from: High-throughput screening of inorganic compounds for dielectric and optical properties to enable the discovery of novel materials
Dielectrics are an important class of materials that are ubiquitous in modern electronic applications. Even though their properties are important for the performance of devices, the number of compounds with known dielectric constant is on the order of a few hundred. Here, we use Density Functional Perturbation Theory as a way to screen for the dielectric constant and refractive index of materials in a fast and computationally efficient way. Our results form the largest database to date, containing the full dielectric tensor for 1,056 compounds. Details regarding the computational methodology and technical validation are presented along with the format of our publicly available data. In addition, we integrate our dataset with the Materials Project allowing users easy access to material properties. Finally, we explain how our dataset and calculation methodology can be used in the search for novel dielectric compounds.
Data from: High-throughput screening of inorganic compounds for dielectric and optical properties to enable the discovery of novel materials
Open the record for dataset details and reuse information.
High throughput phenotypic screen and transcriptional analysis identify new compounds, targets and pathways for macrophage reprogramming I
GEO Series GSE144989. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
A high-throughput screen reveals SALL4-induced oxidative phosphorylation vulnerabilities in cancer
GEO Series GSE114808. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
High-throughput screen reveals purinergic receptor as a therapeutic target in circadian β-cell failure
GEO Series GSE186469. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing; Third-party reanalysis.
High-throughput screen reveals that atypical antipsychotics promote continual efferocytosis by antagonizing dopamine signaling and promoting vitamin A-dependent Arginase 1 upregulation
GEO Series GSE286555. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A Quantitative, High-Throughput Reverse Genetic Screen Reveals Novel Connections Between pre-mRNA Splicing and 5’ and 3’ end Transcript Determinants
GEO Series GSE34330. Saccharomyces cerevisiae. 64 samples. Type: Expression profiling by array; Expression profiling by RT-PCR.
High throughput CRISPR perturbation screens identify epigenetic regulators impacting primordial germ cell development [RNA-seq]
GEO Series GSE259290. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Identification of IKKβ Inhibitor by utilizing a novel KLF15 High-Throughput Screen for Proteinuric Kidney Disease
GEO Series GSE240634. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
High throughput small molecule screening reveals NRF2-dependent and -independent pathways of cellular stress resistance
GEO Series GSE130294. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
A high-throughput screening strategy identifies regulators of alternative splicing via interaction with RNA G-quadruplexes
GEO Series GSE113505. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
High-throughput single cell transcriptome analysis and CRISPR screen identify key β cell-specific disease genes
GEO Series GSE101207. Mus musculus; Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
High-throughput RNAi cell viability screen to identify selective targets for EWS-FLI1 positive Ewing sarcoma
GEO Series GSE73092. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
High throughput screening identifies microRNAs regulating PCSK9 and LDL receptor expression
GEO Series GSE166680. Homo sapiens. 3 samples. Type: Other.
High-Throughput Drug Screening identifies Pazopanib and Clofilium tosylate as effective treatments for malignant rhabdoid tumors
GEO Series GSE102467. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets
GEO Series GSE223599. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.