Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,257
datasets available to search
ShareScore release 0.9.0
Dataset results
1,257 results for “Human infections”
Human adenovirus serotype 5 infection dysregulates cysteine, purine, and unsaturated fatty acid metabolism in fibroblasts
Open the record for dataset details and reuse information.
The combined impact of persistent infections and human genetic variation on C-reactive protein levels
<p>GWAS summary statistics for high-sensitive C-reactive protein (hsCRP) levels, and list of the 1809 SNPs included in the hsCRP polygenic risk score (CRP-PRS) calculation. </p>
Genome graphs detect human polymorphisms in active epigenomic states during influenza infection: code and processed data
<p>Manuscript, figure, and analysis code and processed data for the Groza et al (2022) preprint.</p>
Fig. 2 in Epidemiology of Trichinella infection in wild boar from Spain and its impact on human health during the period 2006-2019
Fig. 2. Occurrence of Trichinella infection in wild boar in Spain from 2006 to 2019.
Dataset - Dynamic persistence of intracellular bacterial communities of uropathogenic Escherichia coli in a human bladder-chip model of urinary tract infections
<p>Dataset for manuscript posted at biorxiv: https://doi.org/10.1101/2021.01.03.42483 and in revision for eLife. Data corresponding to each main figure and its associated figure supplements are in seperate .zip folders.</p>
Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes
<p>The surface polysacharide arabinomannan (AM) and related glycolipid lipoarabinomannan (LAM) play critical roles in tuberculosis pathogenesis. Human antibody responses to AM/LAM are heterogenous and knowledge of reactivity to specific glycan epitopes at the monoclonal level is limited, especially in individuals who can control <i><span>M. tuberculosis</span></i> infection<span>. </span>We generated human IgG mAbs to AM/LAM from B cells of two asymptomatic individuals exposed to or latently infected with <i><span>M. tuberculosis</span></i>. We here show that two of these mAbs have high affinity to AM/LAM, are non-competing, and recognize different glycan epitopes <span>distinct from other anti-AM/LAM mAbs reported. Both mAbs recognize virulent </span><i><span>M. tuberculosis</span></i><span> and nontuberculous mycobacteria with marked differences, can be used for the detection of urinary LAM, and can detect </span><i><span>M. tuberculosis</span></i><span> and LAM in infected lungs. These mAbs enhance our understanding of the spectrum of antibodies to AM/LAM epitopes </span>in humans <span>and</span> are valuable for <span>tuberculosis</span> diagnostic and research applications.</p>
Transcriptome profiling of human monocytes from accute phase and convalescent patients infected with Plasmodium vivax malaria
<p> RNA sequencing raw data of monocytes obtained from five patients in acute phase of <em>Plasmodium vivax </em>malaria and 45 days after treatment. Individuals from Rondônia (Brazil) were between 18 and 60 years and attended to the exclusion criteria: chronic inflammatory or infectious diseases, pregnancy, and breastfeeding. Diagnostic of malaria by clinical symptoms and thick blood smear was also confirmed by qPCR. According to the recommended protocol of the Brazilian Ministry of Health patients were treated with chloroquine associated to primaquine. Protocols used were approved by the Ethical Committees on Human Experimentation from Instituto Rene ́ Rachou, Fiocruz, and National Ethical Council (CAAE: 59902816.7.0000.5091). </p> <p> Sequencing was performed in a NextSeq 500 system using the NextSeq 500/550 High Output Kit v2.5 for 75 cycles (both from Illumina). Before sequencing total mRNA samples were prepared using TruSeq Stranded mRNA Kit (Illumina) according to the manufacturer’s protocol. Files are in FASTQ format, just as they were downloaded from Illumina's cloud environment (BaseSpace) right after sequencing. Files are identified by patient number (1 to 5) and health condition: acute phase of the disease or convalescent (45 days after treatment).</p>
Data for: The impact of wildlife and environmental factors on hantavirus infection in host and its translation into human risk
<p><span>Identifying factors that drive infection dynamics in reservoir host populations is essential in understanding human risk from wildlife-originated zoonoses. We studied zoonotic <em>Puumala</em> <em>orthohantavirus</em> (PUUV) in the host, the bank vole (<em>Myodes</em> <em>glareolus</em>), populations in relation to the host population, rodent and predator community and environment-related factors and whether these processes are translated into human infection incidence. We used 5-year rodent trapping and bank vole PUUV serology data collected from 30 sites located in 24 municipalities in Finland. We found that PUUV seroprevalence was negatively associated with the abundance of red foxes, but this process did not translate into human disease incidence, which showed no association with PUUV seroprevalence. The abundance of weasels, the proportion of juvenile bank voles in the host populations and rodent species diversity were negatively associated with the abundance index of PUUV-positive bank voles, which, in turn, showed a positive association with human disease incidence. Our results suggest certain predators, high proportion of young bank vole individuals and a diverse rodent community, may reduce PUUV risk for humans through their negative impacts on the abundance of infected bank voles.</span></p>
Complete bacterial assemblies for 'Enterobacterales plasmid sharing amongst human bloodstream infections, livestock, wastewater, and waterway niches in Oxfordshire, UK'
<p>Complete bacterial assemblies from the journal article 'Matlock, William, et al. "<em>Enterobacterales</em> plasmid sharing amongst human bloodstream infections, livestock, wastewater, and waterway niches in Oxfordshire, UK." <em>Elife</em> 12 (2023): e85302.'</p> <p>'assemblies.zip' contains assemblies for <em>n</em>=1,458 isolates with circularised chromosomes and <em>n</em>=3,697 circularised plasmids.</p> <p><strong>If you use this data please cite the journal article <em>and</em> the Zenodo DOI. </strong></p>
Safety, effectiveness, and skin immune response in a controlled human infection model of sand fly transmitted cutaneous leishmaniasis.
<p>Safety, effectiveness, and skin immune response in a controlled human infection model of sand fly transmitted cutaneous leishmaniasis.</p><p>Vivak Parkash1, Helen Ashwin1, Shoumit Dey1, Jovana Sadlova2, Barbora Vojtkova2, Katrien Van Bocxlaer1,3, Rebecca Wiggins1, David Thompson4 Nidhi Sharma Dey1, Charles L. Jaffe5, Eli Schwartz6, Petr Volf2, Charles J. N. Lacey1, Alison M. Layton1,3 * and Paul M. Kaye1,3 *.</p><p> </p><p>1 York Biomedical Research Institute, Hull York Medical School, University of York, York, UK</p><p>2 Department of Parasitology, Faculty of Science, Charles University, Viničná 7, Prague, Czech Republic</p><p>3 Skin Research Centre, Hull York Medical School, York, UK</p><p>4 York and Scarborough Teaching Hospitals NHS Foundation Trust, York, UK </p><p>5 Department of Microbiology and Molecular Genetics, Kuvin Center for the Study of Infectious and Tropical Diseases, IMRIC, The Hebrew University – Hadassah Medical School, Jerusalem, Israel</p><p>6 The Center for Geographic Medicine and Tropical Diseases, Chaim Sheba Medical Center, and The School of Medicine, Tel Aviv University, Israel.</p><p> </p><p>*Corresponding authors: paul.kaye@york.ac.uk and alison.layton@hyms.ac.uk</p><p> </p>
Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection
ClinicalTrials.gov study NCT04247282. IPD Sharing: YES. Countries: 1. Publications: 3.
A Phase I Study of Quadrivalent Human Papilloma Virus (HPV) (Types 6, 11, 16, 18) Recombinant Vaccine in HIV-Infected and HIV-Negative Pre-Adolescents, Adolescents, and Young Adults
ClinicalTrials.gov study NCT00798265. IPD Sharing: YES. Countries: 1. Publications: 3.
A Study of Heterologous Vaccine Regimen of Adenovirus Serotype 26 Mosaic4 Human Immunodeficiency Virus(Ad26.Mos4.HIV), Adjuvanted Clade C gp140 and Mosaic gp140 to Prevent HIV-1 Infection Among Cis-ge
ClinicalTrials.gov study NCT03964415. IPD Sharing: YES. Countries: 9. Publications: 1.
Study to Evaluate the Safety and Efficacy of Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Abacavir/Dolutegravir/Lamivudine in Human Immunodeficiency Virus-1 (HIV-1) Infected, Antiretroviral
ClinicalTrials.gov study NCT02607930. IPD Sharing: YES. Countries: 10. Publications: 9.
Safety and Efficacy Study of Vaccine Schedule With Ad26.Mos.HIV and MVA-Mosaic in Human Immunodeficiency Virus (HIV)-Infected Adults
ClinicalTrials.gov study NCT02919306. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Development of a Human Model of Respiratory Syncytial Virus Infection
ClinicalTrials.gov study NCT01349543. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate the Pharmacokinetics, Safety, Tolerability, and Antiviral Activity of Rilpivirine (TMC278) in Human Immunodeficiency Virus Infected Adolescents and Children Aged Greater Than or Eq
ClinicalTrials.gov study NCT00799864. IPD Sharing: Not stated. Countries: 8. Publications: 1.
A Study of TMC278 in Human Immunodeficiency Virus Type 1 Infected Patients, Who Are Not Treated With Antiretroviral Medicines
ClinicalTrials.gov study NCT00110305. IPD Sharing: Not stated. Countries: 14. Publications: 1.
Pharmacokinetics and Safety Study of Tipranavir in Combination With Low Dose Ritonavir in Human Immunodeficiency Virus (HIV)-Infected Children
ClinicalTrials.gov study NCT00076999. IPD Sharing: Not stated. Countries: 10. Publications: 2.
Study to Evaluate the Safety and Efficacy of Stribild Versus Atripla in Human Immunodeficiency Virus, Type 1 (HIV-1) Infected, Antiretroviral Treatment-Naive Adults
ClinicalTrials.gov study NCT01095796. IPD Sharing: Not stated. Countries: 2. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.