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Dataset results
262 results for “Human leukemia”
Data from: A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells
Technological advances have enabled the analysis of cellular protein and RNA levels with unprecedented depth and sensitivity, allowing for an unbiased re-evaluation of gene regulation during fundamental biological processes. Here, we have chronicled the dynamics of protein and mRNA expression levels across a minimally perturbed cell cycle in human myeloid leukemia cells using centrifugal elutriation combined with mass spectrometry-based proteomics and RNA-Seq, avoiding artificial synchronization procedures. We identify myeloid-specific gene expression and variations in protein abundance, isoform expression and phosphorylation at different cell cycle stages. We dissect the relationship between protein and mRNA levels for both bulk gene expression and for over ∼6000 genes individually across the cell cycle, revealing complex, gene-specific patterns. This data set, one of the deepest surveys to date of gene expression in human cells, is presented in an online, searchable database, the Encyclopedia of Proteome Dynamics (http://www.peptracker.com/epd/).
Data from: Characterization of leukemia-inducing genes using a proto-oncogene/homeobox gene retroviral human cDNA library in a mouse in vivo model
The purpose of this research is to develop a method to screen a large number of potential driver mutations of acute myeloid leukemia (AML) using a retroviral cDNA library and murine bone marrow transduction-transplantation system. As a proof-of-concept, murine bone marrow (BM) cells were transduced with a retroviral cDNA library encoding well-characterized oncogenes and homeobox genes, and the virus-transduced cells were transplanted into lethally irradiated mice. The proto-oncogenes responsible for leukemia initiation were identified by PCR amplification of cDNA inserts from genomic DNA isolated from leukemic cells. In an initial screen of ten leukemic mice, the MYC proto-oncogene was detected in all the leukemic mice. Of ten leukemic mice, 3 (30%) had MYC as the only transgene, and seven mice (70%) had additional proto-oncogene inserts. We repeated the same experiment after removing MYC-related genes from the library to characterize additional leukemia-inducing gene combinations. Our second screen using the MYC-deleted proto-oncogene library confirmed MEIS1and the HOX family as cooperating oncogenes in leukemia pathogenesis. The model system we introduced in this study will be valuable in functionally screening novel combinations of genes for leukemogenic potential in vivo, and the system will help in the discovery of new targets for leukemia therapy.
Mass spectrometry data on study of CNOT3 function in human myeloid leukemia cells
<p>Mass spectrometry data on study of CNOT3 function in human myeloid leukemia cells</p>
AMG 176 First in Human Trial in Participants With Relapsed or Refractory Multiple Myeloma and Participants With Relapsed or Refractory Acute Myeloid Leukemia
ClinicalTrials.gov study NCT02675452. IPD Sharing: YES. Countries: 5. Publications: 0.
Data from: Characterization of leukemia-inducing genes using a proto-oncogene/homeobox gene retroviral human cDNA library in a mouse in vivo model
Open the record for dataset details and reuse information.
Data from: A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells
Open the record for dataset details and reuse information.
Identification of a common prognostic gene signature and its association with miR-181 regulation in human acute myeloid leukemia
GEO Series GSE30257. Homo sapiens. 158 samples. Type: Expression profiling by array.
Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia
GEO Series GSE150081. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Human B-cell precursor acute lymphoblastic leukemia cells overexpressing ST6Gal1
GEO Series GSE185611. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
GEO Series GSE12363. Homo sapiens; Mus musculus. 49 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array.
PRMT5 methylome profiling uncovers a direct link to splicing regulation in human acute myeloid leukemia
GEO Series GSE129652. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
Inhibition of DOT1L and PRMT5 promote synergistic anti-tumor activity in a human MLL leukemia model induced by CRISPR/Cas9
GEO Series GSE128342. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Gene expression data from sorted primary human acute myeloid leukemia (AML) samples
GEO Series GSE127200. Homo sapiens. 30 samples. Type: Expression profiling by array.
Real-time quantitative PCR analysis for NF-kB related genes of mouse bone marrow with engrafted human leukemia cells after C-miR146a treatment
GEO Series GSE141402. Mus musculus. 9 samples. Type: Expression profiling by RT-PCR.
Transcriptomes of normal human mature B cells and REH B-cell acute lymphoblastic leukemia cells: effect of FBXW7 isoform knockdown or knockout followed by reconstitution
GEO Series GSE212312. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing.
Acute Myeloid Leukemia iPSCs reveal a role for RUNX1 in the maintenance of human Leukemia Stem Cells
GEO Series GSE124992. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Dynamic transcriptomes of human myeloid leukemia cells
GEO Series GSE46164. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
CD200 expression marks leukemia stem cells (LSC) in human AML part 2
GEO Series GSE159321. Homo sapiens. 2 samples. Type: Expression profiling by array.
Inducible PAX5 expression in a human B lymphoblastic leukemia cell line
GEO Series GSE57480. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
BCR-ABL1 and a dominant negative isoform of Ikaros cooperate to induce human acute myeloid leukemia
GEO Series GSE45452. Homo sapiens. 16 samples. Type: Expression profiling by array.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.