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228
datasets available to search
ShareScore release 0.9.0
Dataset results
228 results for “Immunotherapy targets”
Detection of Plasmatic Cell-free BRAF and NRAS Mutations : a New Tool for Monitoring Patients with Metastatic Malignant Melanoma Treated with Targeted Therapies or Immunotherapy ( MALT )
ClinicalTrials.gov study NCT03493230. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
ClinicalTrials.gov study NCT03866382. IPD Sharing: YES. Countries: 2. Publications: 1.
Granzyme B-targeted PET Imaging Monitoring Tumor Responses to Immunotherapy
ClinicalTrials.gov study NCT06916442. IPD Sharing: NO. Countries: 1. Publications: 1.
The Rome Trial From Histology to Target: the Road to Personalize Target Therapy and Immunotherapy
ClinicalTrials.gov study NCT04591431. IPD Sharing: NO. Countries: 1. Publications: 1.
Safely Delivered Targeted High-dose Irradiation Followed by Adoptive Immunotherapy with Regulatory and Conventional T Cells to Increase Potency of Hematopoietic Stem Cell Transplantation in High-risk
ClinicalTrials.gov study NCT06845592. IPD Sharing: Not stated. Countries: 1. Publications: 61.
A Clinical Trial of Neoadjuvant Targeted Therapy, Immunotherapy, and Lysogenic HSV-Based Virotherapy in Resectable Head and Neck Squamous Cell Carcinoma
ClinicalTrials.gov study NCT07010120. IPD Sharing: NO. Countries: 1. Publications: 7.
Immunotherapy With Ipilimumab and Nivolumab Preceded or Not by a Targeted Therapy With Encorafenib and Binimetinib
ClinicalTrials.gov study NCT03235245. IPD Sharing: YES. Countries: 9. Publications: 1.
Basiliximab in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Undergoing Targeted Immunotherapy and Temozolomide-Caused Lymphopenia
ClinicalTrials.gov study NCT00626483. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Targeting metabotropic glutamate receptor 4 for cancer immunotherapy
<p><span><span><span><span><span><span><span><span><span><span><span>The complex mechanism regulating the immunosuppressive tumor microenvironment (TME) remains poorly understood. Here, we reported a novel role of the metabotropic glutamate receptor-4 (GRM4) in suppressing the anti-tumor immunity. We revealed in three murine syngeneic tumor models (B16, MC38, and 3LL) that either genetic knockout (<i>Grm4</i><sup>−/−</sup>) or pharmacological inhibition led to significant delay in tumor growth and synergized with immune checkpoint inhibitors in male mice. Mechanistically, perturbation of GRM4 resulted in a strong anti-tumor immunity by promoting nature killer (NK), CD4<sup>+</sup> and CD8<sup>+</sup> T cells towards an activated, proliferative, and functional phenotype. Single-cell RNA-sequencing and T Cell Receptor (TCR) profiling further defined the clonal expansion and immune landscape changes in CD8<sup>+</sup> T cells. Mechanistically, <i>Grm4</i><sup>-/- </sup>intrinsically activated IFN-g production in CD8<sup>+</sup> T cells through cAMP/CREB-mediated pathway. Our study appears to be of clinical significance as a signature of NK<sup>high</sup>-GRM4<sup>low</sup> and CD8<sup>high</sup>-GRM4<sup>low</sup> correlated with improved survival in melanoma patients. Therefore, targeting GRM4 could be exploited as a new approach for cancer immunotherapy. </span></span></span></span></span></span></span></span></span></span></span></p>
Using a Targeted Cancer Vaccine (Galinpepimut-S) With Immunotherapy (Nivolumab) in Mesothelioma
ClinicalTrials.gov study NCT04040231. IPD Sharing: YES. Countries: 1. Publications: 0.
Immunotherapy Targeted Against Cytomegalovirus in Patients With Newly-Diagnosed WHO Grade IV Unmethylated Glioma
ClinicalTrials.gov study NCT03927222. IPD Sharing: NO. Countries: 1. Publications: 0.
Neoadjuvant Radiotherapy Plus Targeted Therapy and Immunotherapy vs. Targeted Therapy Plus Immunotherapy in Resectable HNSCC
ClinicalTrials.gov study NCT06804850. IPD Sharing: NO. Countries: 0. Publications: 9.
Neoadjuvant Her2-targeted Therapy and Immunotherapy With Pembrolizumab [IIT2018-04-MCARTHUR-NEOHP]
ClinicalTrials.gov study NCT03747120. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Immunotherapy (Sasanlimab) in Combination With Targeted Therapies in People With Advanced Non-small Cell Lung Cancer (NSCLC) (Landscape 1011 Study)
ClinicalTrials.gov study NCT04585815. IPD Sharing: YES. Countries: 4. Publications: 0.
A Phase II, Single-Arm, Prospective Trial on the Efficacy and Safety of QL1706 Combination Regimen as Second-Line Therapy for Targeted-Immunotherapy-Resistant Hepatocellular Carcinoma
ClinicalTrials.gov study NCT07138885. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study on the Reactogenicity, Safety and Immune Response of a Targeted Immunotherapy Against HSV in Healthy Japanese Participants Aged 18-40 Years
ClinicalTrials.gov study NCT05989672. IPD Sharing: YES. Countries: 1. Publications: 0.
Study on the Efficacy and Safety of Transarterial Chemoembolization Combined with Targeted Immunotherapy in Patients with Unresectable Hepatocellular Carcinoma
ClinicalTrials.gov study NCT06715072. IPD Sharing: NO. Countries: 0. Publications: 1.
CD47-targeted nano-immunotherapy for treatment of atherosclerosis
Open the record for dataset details and reuse information.
Targeting metabotropic glutamate receptor 4 for cancer immunotherapy
Open the record for dataset details and reuse information.
Targeted erythrophagocyte reprogramming of Kupffer cells halts cancer immunotherapy associated liver toxicity [Ter119 experiment]
GEO Series GSE202917. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.