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235
datasets available to search
ShareScore release 0.9.0
Dataset results
235 results for “Inflammasome”
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients
ClinicalTrials.gov study NCT06465095. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Role of the NLRP3 Inflammasome in Escherichia Coli and Staphylococcus Aureus Bacteria
ClinicalTrials.gov study NCT03869593. IPD Sharing: NO. Countries: 1. Publications: 5.
NLRP3 Inflammasome and Physical Therapy in ICU-Acquired Weakness
ClinicalTrials.gov study NCT07017517. IPD Sharing: NO. Countries: 1. Publications: 103.
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis
ClinicalTrials.gov study NCT02539147. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Effect of Fasting on the Asthma Inflammasome
ClinicalTrials.gov study NCT02471300. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Assessing the Role of the NLRP3 Inflammasome in Intercritical Gout
ClinicalTrials.gov study NCT04125459. IPD Sharing: NO. Countries: 1. Publications: 26.
Repurposing Fenofibrate in Modulating mTOR/NLRP3 Inflammasome in Patients With Ulcerative Colitis
ClinicalTrials.gov study NCT05781698. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Inflammasome Activation Via Circulating Metabolites
ClinicalTrials.gov study NCT03191175. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Potential Role of Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients: Impact of Ferretin and D -Dimer.
ClinicalTrials.gov study NCT06080750. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
Epigenetic Analysis of Regulation of the Inflammasome-activating NLRP3 Gene in Monocytes From Atrial Fibrillation Patients and Controls
ClinicalTrials.gov study NCT04766814. IPD Sharing: Not stated. Countries: 1. Publications: 25.
Role of Inflammasomes in COVID-19 Disease
ClinicalTrials.gov study NCT04385017. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients
ClinicalTrials.gov study NCT02833909. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Inflammasomes in Cell Death in FTMH, ERM, and RRD
ClinicalTrials.gov study NCT03332758. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Data from: Upregulation of NLRP3 inflammasome in the tears and ocular surface of dry eye patients
Open the record for dataset details and reuse information.
Immunofluorescence images: Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell derived antigen
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NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy
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S.aureus in NLRP1 inflammasome activation in AD_Online Supporting information
<p>Full list of genes that gave PP4 > 0.8 in the L. Paternoster et al and UK biobank dataset and the corresponding eQTL dataset. PP-posterior probability of colocalization, abf-analysis using Bayes Factors , nsnps- number of significant eQTL associations.</p>
Data from: A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP
Antimicrobial peptides (AMPs) are one of the most important defense mechanisms against bacterial infections in insects, plants, non-mammalian vertebrates, and mammals. In the present study, a class of synthetic AMPs was evaluated for anti-inflammatory activity. One cationic AMP, GW-A2, demonstrated the ability to inhibit the expression levels of nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-activated macrophages. GW-A2 reduced LPS-induced increases in the phosphorylation of mitogen-activated protein kinase and protein kinase C-α/δ and the activation of NF-κB. GW-A2 also inhibited NLRP3 inflammasome activation induced by LPS and ATP. Furthermore, in the mice injected with LPS, GW-A2 reduced (1) the concentration of IL-1β, IL-6 and TNF-α in the serum; (2) the concentration of TNF-α in the peritoneal lavage; (3) the expression levels of iNOS, COX-2 and NLRP3 in the liver and lung; (4) the infiltration of polymorphonuclear neutrophils in the liver and lung. The underlying mechanisms for the anti-inflammatory activity of GW-A2 were found to be partially due to LPS and ATP neutralization. These results provide insights into how GW-A2 inhibits inflammation and the NLRP3 inflammasome and provide a foundation for the design of rational therapeutics for inflammation-related diseases.
Fig. 3 in Germacranolide- and guaianolide-type sesquiterpenoids from Achillea alpina L. reduce insulin resistance in palmitic acid-treated HepG2 cells via inhibition of the NLRP3 inflammasome pathway
Fig. 3. Experimental and calculated ECD spectra of 1–8.
Fig. 2. 1H–1H in Germacranolide- and guaianolide-type sesquiterpenoids from Achillea alpina L. reduce insulin resistance in palmitic acid-treated HepG2 cells via inhibition of the NLRP3 inflammasome pathway
Fig. 2. 1H–1H COSY, key HMBC and ROESY correlations of compounds 1 and 6–8.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.