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90 results for “Interleukin-6”
Interleukin-6 Inhibitors and Drug-drug Interactions in Patients With Rheumatoid Arthritis
ClinicalTrials.gov study NCT04842981. IPD Sharing: NO. Countries: 1. Publications: 1.
Leucine-enriched Branched-chain Amino Acid on Muscle Thickness, Interleukin-6, SOFA Score in Critical Illness
ClinicalTrials.gov study NCT06167772. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Analyses of Interleukin-6, Presepsin and Pentraxin-3 in the Diagnosis and Severity of Late-onset Preeclampsia
ClinicalTrials.gov study NCT04126902. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Effect of the Interleukin-6 Receptor Antagonist Tocilizumab in Non-ST Elevation Myocardial Infarction
ClinicalTrials.gov study NCT01491074. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Levels of Interleukin-6 andTransforming Growth Factor Beta in HCV Patients Sera
ClinicalTrials.gov study NCT03882307. IPD Sharing: NO. Countries: 1. Publications: 7.
Effect of Interleukin-6 Receptor Inhibition in Patients With Ischemic Stroke Undergoing Endovascular Treatment
ClinicalTrials.gov study NCT06238024. IPD Sharing: YES. Countries: 1. Publications: 0.
Effect of Quranic Recitation and Classical Music on Pain Intensity and Interleukin-6 Levels After Lower Limb Orthopedic Surgery with Intrathecal Anesthesia
ClinicalTrials.gov study NCT06713044. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Impaired T Cell Responsiveness to Interleukin-6 in Hematological Patients with Invasive Aspergillosis
Invasive mold infections (IMI) are among the most devastating complications following chemotherapy and hematopoietic stem cell transplantation (HSCT), with high mortality rates. Yet, the molecular basis for human susceptibility to invasive aspergillosis (IA) and mucormycosis remain poorly understood. Herein, we aimed to characterize the immune profile of individuals with hematological malignancies (n = 18) who developed IMI during the course of chemotherapy or HSCT, and compared it to that of hematological patients who had no evidence of invasive fungal infection (n = 16). First, we measured the expression of the pattern recognition receptors pentraxin 3, dectin-1, and Toll-like receptors (TLR) 2 and 4 in peripheral blood of chemotherapy and HSCT recipients with IMI. Compared to hematological controls, individuals with IA and mucormycosis had defective expression of dectin-1; in addition, patients with mucormycosis had decreased TLR2 and increased TLR4 expression. Since fungal recognition via dectin-1 favors T helper 17 responses and the latter are highly dependent on activation of the signal transducer and activator of transcription (STAT) 3, we next used phospho-flow cytometry to measure the phosphorylation of the transcription factors STAT1 and STAT3 in response to interferon-gamma (IFN-γ) and interleukin (IL)-6, respectively. While IFN-γ/STAT1 signaling was similar between groups, naïve T cells from patients with IA, but not those with mucormycosis, exhibited reduced responsiveness to IL-6 as measured by STAT3 phosphorylation. Furthermore, IL-6 increased Aspergillus-induced IL-17 production in culture supernatants from healthy and hematological controls but not in patients with IA. Altogether, these observations suggest an important role for dectin-1 and the IL-6/STAT3 pathway in protective immunity against Aspergillus.
raw data - Correlation of interleukin-1β and interleukin-6 levels with osteoarthritic lesions of the knee
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Clazakizumab (Anti-Interleukin 6 (IL-6) Monoclonal) Compared to Placebo for Coronavirus Disease 2019 (COVID-19)
ClinicalTrials.gov study NCT04348500. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Study to Investigate Interleukin-6 (IL-6) and IL-6/Soluble IL-6 Receptor (sIL-6R) Complex Levels in Subjects With Active Inflammatory Bowel Disease
ClinicalTrials.gov study NCT02790281. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Effects of Surgery Start Time on Postoperative Interleukin-6, Interleukin-8, and Cortisol
ClinicalTrials.gov study NCT03076827. IPD Sharing: YES. Countries: 0. Publications: 2.
Interferon Alfa and Interleukin-6 in Treating Patients With Recurrent Multiple Myeloma
ClinicalTrials.gov study NCT00470093. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effect of Ketamine on Interleukin-6 Synthesis in Hepatic Resections Requiring Temporary Porto-arterial Occlusion
ClinicalTrials.gov study NCT00978757. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Impaired T Cell Responsiveness to Interleukin-6 in Hematological Patients with Invasive Aspergillosis
Open the record for dataset details and reuse information.
Integrated miRNA and gene expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation [gene]
GEO Series GSE68164. Homo sapiens. 12 samples. Type: Expression profiling by array.
Muscle and adipose transcriptome in a mouse model of cachexia induced by orthotopic pancreatic cancer, with and without tumor-derived interleukin-6 (IL-6)
GEO Series GSE123310. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
Interleukin-6 (IL-6) deficiency enhances intramembranous osteogenesis following stress fracture in mice
GEO Series GSE157460. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Integrated miRNA and gene expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation
GEO Series GSE68166. Homo sapiens. 24 samples. Type: Expression profiling by array; Other.
Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes
GEO Series GSE202045. Mus musculus; Homo sapiens. 108 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.