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Dataset results
204 results for “Ionizing radiation”
Low dose ionizing radiation treated lymphoblastoid cells
Irradiated cell lines exposed to 1-10 cGy 2 Lymphoblastoid cell lines (GM15510 and GM15036) irradiated 1 2.5 5 7.5 10 cGy RNA is isolated and labeled using a T7 amplification Arcturus kit for hybridization on triplicate arrays.
Non-targeted effects of low dose ionizing radiation act via TGF-beta to promote mammary carcinogenesis
This is a genome-wide approach to identifying genes persistently induced in the mouse mammary gland by acute whole body low dose ionizing radiation (10cGy) 1 and 4 weeks after exposure. Gene expression that is modified under these parameters were compared between Tgfb1 wild type and heterozygote littermates in order to determine which genes induced or repressed by radiation were mediated via Tgfb1 status. Differential gene expression was analyzed in Tgfb1 heterozygote and wild type littermate 4th mammary glands after whole body exposure to an acute dose of 10cGy ionizing radiation. Estrus cycle was normalized in all mice two days prior to irradiation by injection with an estrogen and progesterone mixture. It is widely believed that the carcinogenic action of ionizing radiation is due to targeted DNA damage and resulting mutations but there is also substantial evidence that non-targeted radiation effects alter epithelial phenotype and the stromal microenvironment. Activation of transforming growth factor beta 1 (TGFbeta) is a non-targeted radiation effect that mediates cell fate decisions following DNA damage and regulates microenvironment composition; it could either suppress or promote cancer. Gene expression profiling shown herein demonstrates that low dose radiation (10 cGy) elicits persistent changes in Tgfb1 wild type and heterozygote murine mammary gland that are highly modulated by TGFbeta. We asked if such non-targeted radiation effects contribute to carcinogenesis by using a novel radiation chimera model. Unirradiated Trp53 null mammary epithelium was transplanted to the mammary stroma of mice previously exposed to a single low (10 -100 cGy) radiation dose. By 300 days 100% of transplants in irradiated hosts at either 10 or 100 cGy had developed Trp53 null breast carcinomas compared to 54% in unirradiated hosts. Tumor growth rate was also increased by high but not low dose host irradiation. In contrast irradiation of Tgfb1 heterozygote mice prior to transplantation failed to decrease tumor latency or increase growth rate at any dose. Host irradiation significantly reduced the latency of invasive ductal carcinoma compared to spindle cell carcinoma as well as those tumors negative for smooth muscle actin in wild type but not Tgfb1 heterozygote mice. However irradiation of either host genotype significantly increased the frequency of estrogen receptor negative tumors. These data demonstrate two concepts critical to understanding radiation risks. First non-targeted radiation effects can significantly promote the frequency and alter the features of epithelial cancer. Second radiation-induced TGFbeta activity is a key mechanism of tumor promotion. Keywords: Differential gene expression after low dose irradiation Two genotypes: TGBbeta1 heterozygote and wildtype mouse mammary glands. Two time points post-10cGy-irradiation per genotype (1 week 4 weeks); control time point was 1 week post-sham-irradiation. Two or three replicates per time point.
Chronic low dose-rate versus acute ionizing radiation induced gene expression in primary derived prostate fibroblasts
Using a novel flood source construct we performed a direct comparison of genome-wide gene expression regulations resulting from exposure of primary human prostate fibroblast cultures to acute (10cGy and 200cGy) and longer-term chronic (1.0-2.45cGy cumulative over 24hr) exposures.
Effects of Ionizing Radiation on Self Renewal and Pluripotency of Human Embryonic Stem Cells
GEO Series GSE20951. Homo sapiens. 12 samples. Type: Expression profiling by array.
Genome-wide map of p53 binding sites by ChIP-seq in human lymphoblastoid cell lines treated with ionizing radiation
GEO Series GSE46993. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation [RNA-Seq]
GEO Series GSE110762. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Pro-inflammatory cytokine and high doses of ionizing radiation have similar effects on the expression of NF-kappaB-dependent genes [RNA-seq]
GEO Series GSE110386. Homo sapiens. 45 samples. Type: Expression profiling by high throughput sequencing.
Skin transcriptomics predict outcome after ionizing radiation exposure with potential dosimetric applications in a mouse model
GEO Series GSE185149. Mus musculus. 82 samples. Type: Expression profiling by array.
Venetoclax cooperates with ionizing radiation to attenuate Diffuse Midline Glioma tumor growth
GEO Series GSE198979. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing; Other.
Genome-wide DNA damage response following ionizing radiation
GEO Series GSE60526. Homo sapiens. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Ionizing Radiation Induced Gene and micro RNA Expression Alterations in Human Peripheral Blood Mononuclear Cells
GEO Series GSE55955. Homo sapiens. 56 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Effect of ionizing radiation on transcriptome during neural differentiation of hESC
GEO Series GSE137800. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
Uncovering genetic dependencies in the DNA repair network after ionizing radiation
GEO Series GSE290153. Homo sapiens. 6 samples. Type: Other.
Ionizing Radiation Induced Gene Expression Alterations in Human Peripheral Blood Mononuclear Cells
GEO Series GSE55953. Homo sapiens. 28 samples. Type: Expression profiling by array.
RNA-Seq analysis of human lens epithelial cells exposed to ionizing radiation
GEO Series GSE120805. Homo sapiens. 70 samples. Type: Expression profiling by high throughput sequencing.
The mutational landscape of cancer’s vulnerability to ionizing radiation
GEO Series GSE216711. Homo sapiens. 96 samples. Type: Expression profiling by high throughput sequencing.
RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation [ChIP-Seq]
GEO Series GSE110800. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Global Transcriptional Response of Escherichia coli Exposed In Situ to Different Low-Dose Ionizing Radiation Sources
GEO Series GSE208658. Escherichia coli. 30 samples. Type: Expression profiling by high throughput sequencing.
Pro-inflammatory cytokine and high doses of ionizing radiation have similar effects on the expression of NF-kappaB-dependent genes
GEO Series GSE110387. Homo sapiens. 63 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Selective DNA-PK inhibition enhances chemotherapy and ionizing radiation activity in soft-tissue sarcomas
GEO Series GSE243758. synthetic construct; Homo sapiens. 3 samples. Type: Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.