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125 results for “JNK”

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zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-19T15:20:00+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=JTBMdp4t1R8</li> <li>strain : VC8</li> <li>timestamp : 2011-08-19T15:20:00+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : clockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food L_2011_08_19__15_20___4___10</li> <li>total time (s) : 899.0</li> <li>frames per second : 30.03</li> <li>video micrometers per pixel : 4.76371</li> <li>number of segmented skeletons : 25953</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-31T15:29:50+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=4yRQMIttv78</li> <li>strain : VC8</li> <li>timestamp : 2011-08-31T15:29:50+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : clockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food L_2011_08_31__15_29_50___6___8</li> <li>total time (s) : 899.033</li> <li>frames per second : 30.03</li> <li>video micrometers per pixel : 4.60195</li> <li>number of segmented skeletons : 24683</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-25T15:21:12+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=-1yp2OEFZBE</li> <li>strain : VC8</li> <li>timestamp : 2011-08-25T15:21:12+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : anticlockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food R_2011_08_25__15_21_12___6___8</li> <li>total time (s) : 899.033</li> <li>frames per second : 30.03</li> <li>video micrometers per pixel : 4.60195</li> <li>number of segmented skeletons : 26252</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-19T15:59:19+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=NXgQzxnWFw0</li> <li>strain : VC8</li> <li>timestamp : 2011-08-19T15:59:19+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : clockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food L_2011_08_19__15_59_19___6___12</li> <li>total time (s) : 899.067</li> <li>frames per second : 30.03</li> <li>video micrometers per pixel : 4.57167</li> <li>number of segmented skeletons : 20388</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-19T11:00:49+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=_PAaYZrQ5EM</li> <li>strain : VC8</li> <li>timestamp : 2011-08-19T11:00:49+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : clockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food L_2011_08_19__11_00_49___7___1</li> <li>total time (s) : 899.033</li> <li>frames per second : 30.03</li> <li>video micrometers per pixel : 4.11384</li> <li>number of segmented skeletons : 25417</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-31T15:53:43+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=PD_1dkwPFkg</li> <li>strain : VC8</li> <li>timestamp : 2011-08-31T15:53:43+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : anticlockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food R_2011_08_31__15_53_43___7___9</li> <li>total time (s) : 899.0</li> <li>frames per second : 30.03</li> <li>video micrometers per pixel : 4.22941</li> <li>number of segmented skeletons : 20842</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-25T15:43:52+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=Ia_nKJ59wCs</li> <li>strain : VC8</li> <li>timestamp : 2011-08-25T15:43:52+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : anticlockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food R_2011_08_25__15_43_52___7___9</li> <li>total time (s) : 899.0</li> <li>frames per second : 30.03</li> <li>video micrometers per pixel : 4.22941</li> <li>number of segmented skeletons : 25819</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-19T13:00:02+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=SAMrPn3Nv40</li> <li>strain : VC8</li> <li>timestamp : 2011-08-19T13:00:02+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : clockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food L_2011_08_19__13_00_02___2___8</li> <li>total time (s) : 899.0</li> <li>frames per second : 30.03</li> <li>video micrometers per pixel : 4.52306</li> <li>number of segmented skeletons : 25853</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-31T12:29:06+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=9OtbvktULDs</li> <li>strain : VC8</li> <li>timestamp : 2011-08-31T12:29:06+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : anticlockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food R_2011_08_31__12_29_06___2___4</li> <li>total time (s) : 898.362</li> <li>frames per second : 18.3824</li> <li>video micrometers per pixel : 4.45771</li> <li>number of segmented skeletons : 14816</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-19T13:21:00+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=k4Kb4PV9qRU</li> <li>strain : VC8</li> <li>timestamp : 2011-08-19T13:21:00+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : clockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food L_2011_08_19__13_21___3___9</li> <li>total time (s) : 898.967</li> <li>frames per second : 30.03</li> <li>video micrometers per pixel : 4.53662</li> <li>number of segmented skeletons : 26796</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-31T12:49:00+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=_gcudDd07sc</li> <li>strain : VC8</li> <li>timestamp : 2011-08-31T12:49:00+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : clockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food L_2011_08_31__12_49___3___5</li> <li>total time (s) : 898.688</li> <li>frames per second : 24.2131</li> <li>video micrometers per pixel : 4.58337</li> <li>number of segmented skeletons : 21062</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-25T12:39:00+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=vqN5TxM5vsA</li> <li>strain : VC8</li> <li>timestamp : 2011-08-25T12:39:00+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : clockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk-1)IV on food L_2011_08_25__12_39___3___5</li> <li>total time (s) : 898.294</li> <li>frames per second : 27.1003</li> <li>video micrometers per pixel : 4.58337</li> <li>number of segmented skeletons : 24208</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo36/100

VC8 jnk-1(gk7)IV | 2011-08-04T12:50:00+01:00

<blockquote> This experiment is part of the C.elegans behavioural database. For more information and the complete collection of experiments visit http://movement.openworm.org </blockquote> <ul> <li>preview link : https://www.youtube.com/watch?v=mrNcIV6uLxM</li> <li>strain : VC8</li> <li>timestamp : 2011-08-04T12:50:00+01:00</li> <li>gene : jnk-1</li> <li>chromosome : IV</li> <li>allele : gk7</li> <li>strain_description : jnk-1(gk7)IV</li> <li>sex : hermaphrodite</li> <li>stage : adult</li> <li>ventral_side : anticlockwise</li> <li>media : NGM agar low peptone</li> <li>arena : <ul> <li>style : petri</li> <li>size : 35</li> <li>orientation : away</li> </ul> </li> <li>food : OP50</li> <li>habituation : 30m wait</li> <li>who : Laura Grundy</li> <li>protocol : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li>lab : <ul> <li>name : William R Schafer</li> <li>location : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li>software : <ul> <li>name : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li>version : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li>featureID : @OMG</li> </ul> </li> <li>base_name : jnk-1 (gk1)IV on food R_2011_08_04__12_50___3___8</li> <li>total time (s) : 898.967</li> <li>frames per second : 30.03</li> <li>video micrometers per pixel : 4.53662</li> <li>number of segmented skeletons : 26459</li> </ul>

opencc-by-4.0Oct 2017View details →

zenodo32/100

JNK Activation Correlates with Cognitive Impairment and Alteration of the Post-Synaptic Element in the 5xFAD AD Mouse Model

The c-Jun N-terminal kinases (JNKs) are a family of proteins that, once activated by stress stimuli, can alter neuronal functions and survival. The JNK cascade plays a crucial role in the post-synaptic neuronal compartment by altering its structural organization and leading, at worst, to an overall impairment of neuronal communication. Increasing evidence suggests that synaptic impairment is the first neurodegenerative event in Alzheimer’s disease (AD). To better elucidate this mechanism, we longitudinally studied 5xFAD mice at three selected time points representative of human AD symptom progression. We tested the mice cognitive performance by using the radial arm water maze (RAWM) in parallel with biochemical evaluations of post-synaptic enriched protein fraction and total cortical parenchyma. We found that 5xFAD mice presented a strong JNK activation at 3.5 months of age in the post-synaptic enriched protein fraction. This JNK activation correlates with a structural alteration of the post-synaptic density area and with memory impairment at this early stage of the disease that progressively declines to cause cell death. These findings pave the way for future studies on JNK as a key player in early neurodegeneration and as an important therapeutic target for the development of new compounds able to tackle synaptic impairment in the early phase of AD pathology

opencc-by-4.0Mar 2023View details →

zenodo32/100

Oncogenic BRAF V600E induces glial proliferation through ERK and neuronal death through JNK

Raw Data Files for the manuscript entitled "Oncogenic BRAF V600E induces glial proliferation through ERK and neuronal death through JNK".

opencc-by-4.0Jan 2022View details →

dryad32/100

DUX4 expression activates JNK and p38 MAP kinases in myoblasts: MAJIQ splicing results

Facioscapulohumoral muscular dystrophy (FSHD) is caused by misexpression of the DUX4 transcription factor in skeletal muscle that results in transcriptional alterations, abnormal phenotypes, and cell death. To gain insight into the kinetics of DUX4-induced stresses, we activated DUX4 expression in myoblasts and performed longitudinal RNA sequencing (GEO GSE205421) paired with proteomics and phosphoproteomics (MassIVE MSV000089812). This analysis revealed changes in cellular physiology including DNA damage and altered mRNA splicing. Phosphoproteomic analysis uncovered widespread changes in protein phosphorylation rapidly following DUX4 induction indicating that alterations in kinase signaling may play a role in DUX4-mediated stress and cell death. Indeed, we demonstrate that two stress-responsive MAP kinase pathways, JNK and p38, are activated in response to DUX4 expression. Inhibition of each of these pathways ameliorated DUX4-mediated cell death in myoblasts. These findings uncover JNK as a novel pathway involved in DUX4-mediated cell death as well as provide additional insights into the role of the p38 pathway, a clinical target for the treatment of FSHD.

opencc-zeroOct 2022View details →

dryad32/100

DUX4 expression activates JNK and p38 MAP kinases in myoblasts: MAJIQ splicing results

Open the record for dataset details and reuse information.

publicOct 2022View details →

zenodo28/100

JNK inhibition in Rett Syndrome models

Datasets produced and used during the current study. Data are mean ± SEM.

opencc-by-4.0Oct 2021View details →

zenodo28/100

Oncogenic BRAF V600E induces glial proliferation through ERK and neuronal death through JNK

Background: Activating V600E in BRAF is a common driver mutation in cancers of multiple tissue origins, including melanoma and glioma. BRAF V600E has also been implicated in neurodegeneration. The present study aims to characterize BRAF V600E on cell death and survival in three major cell types of the CNS: neurons, astrocytes, and microglia. Methods : Multiple primary cultures and cell lines of glial cells and neurons were employed. BRAF V600E as well as BRAF WT expression was mediated by lentivirus or retrovirus. Blockage of downstream effectors were achieved by siRNA. Gene expression data from patients with Parkinson’s disease was analyzed. Results : In astrocytes and microglia, BRAF V600E induces cell proliferation, and the proliferative effect in microglia is mediated by activated ERK but not JNK. Conditioned medium from BRAF V600E -expressing microglia induced neuronal cell death. In neuronal cells, BRAF V600E directly induces cell death, through JNK but not ERK. We further show that BRAF-related genes are enriched in pathways in patients with Parkinson’s disease. Conclusions : Our study identifies distinct consequences mediated by distinct downstream effectors in dividing glial cells and in neurons following the same BRAF mutational activation and a causal link between BRAF-activated microglia and neuronal cell death that does not require physical proximity. It provides insight into a possibly important role of BRAF in neurodegeneration as a result of either dysregulated BRAF in neurons or its impact on glial cells.

opencc-by-4.0Jan 2022View details →

geo24/100

The activation of the NF-κB-JNK pathway is independent of the PI3K-Rac1-JNK pathway involved in the bFGF-regulated human fibroblast cell migration

GEO Series GSE65193. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.

openGEO-OpenJan 2018View details →

ScienceDex guides

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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.

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Allen Brain Atlas

Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.

allen-brain-atlas

neuroscienceopenDocumentation, web resources, and API references are available online.

Last verified 2026-04-30Open record

Annotated Behaviour and Observability Dataset (ABODe)

ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.

abode-home-cage

behavioral-neuroscienceopenThe DataShare record exposes download links for annotations, documentation, license text, and the zipped per-snippet data directory.

Last verified 2026-04-30Open record

DANDI Archive for NWB datasets

DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.

dandi-nwb

electrophysiologyopenPublished Dandiset metadata and archive endpoints are available through the production DANDI API.

Last verified 2026-04-30Open record

International Brain Laboratory public data

The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.

ibl

behavioral-neuroscienceopenPublic sessions can be searched and loaded from the IBL public data server through ONE.

Last verified 2026-04-29Open record

OpenNeuro

OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.

openneuro

neuroscienceopenPublished datasets are available on demand over the internet.

Last verified 2026-04-29Open record