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174 results for “Klebsiella”
Direct prediction for carbapenemase-producing and colistin-resistant Klebsiella pneumoniae isolates from routine MALDI-TOF mass spectrum using machine learning
<p>The emergence of carbapenem-nonsusceptible K. pneumoniae (CnSKP) leads a serious threat to patient survival and colistin resistance makes the treatment of CnSKP more difficultly. To make treatment strategy properly and quickly, we aimed to develop a rapid prediction method for CnSKP and colistin-resistant K. pneumoniae (ColRKP) based on the spectra of routine matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI–TOF MS). The machine learning (ML) model for differentiating CnSKP and carbapenem-susceptible K. pneumoniae (CSKP) showed accuracy of 0.8869 and AUC of 0.9551; the model for ColRKP and colistin-intermediate K. pneumoniae (ColIKP) showed accuracy of 0.8361 and the AUC of 0.8447.</p>
Klebsiella pneumoniae Centrifuge DB
<p>Plascope DB for Klebsiella pneumoniae</p>
Emergence of Klebsiella quasipneumoniae harboring blaKPC-2 in Saudi Arabia
<p>Fasta and gff files for the assemblies that were obtained from the study "Emergence of <em>Klebsiella </em><em>quasipneumoniae</em> harboring blaKPC-2 in Saudi Arabia"</p>
Emergence of Klebsiella quasipneumoniae harboring blaKPC-2 in Saudi Arabia
<p>Fasta and gff files for the assemblies that were obtained from the study "Emergence of <em>Klebsiella </em><em>quasipneumoniae</em> harboring blaKPC-2 in Saudi Arabia"</p>
Figure 1 in Isolation and characterization of Klebsiella oxytoca from the rhizosphere of Lotus corniculatus and its biostimulating features
Figure 1. Pure colonies of the LCK121 strain from the rhizosphere of L. corniculatus.
Klebsiella species assemblies
<p>Assemblies of Klebsiella species. The files comprise assemblies for four sample sites for the following species:</p> <p>KP-Klebsiella pneumoniae</p> <p>KO-klebsiella oxytoca</p> <p>KQV-Klebsiella quasivariicola</p> <p>KQP-Klebsiella quasipneumoniae</p> <p>KV-Klebsiella variicola</p>
Klebsiella pneumonia in Sudan: Multidrug Resistance, Poly-clonal Dissemination and Virulence
<p>Minimum spanning tree (MST) of 84 <em>K. pneumoniae</em> by hospital information. Ridom SeqSphere+ MST for 84 samples based on 2358 columns, pairwise ignoring missing values, logarithmic scale. Cluster distance threshold: 15. Isolates grouped by colour indicating the different hospitals . Samples were collected from five different hospitals, 37 different STs were identified, in addition to 14 transmission clusters, represented by shaded nodes and arrows. Numbers between the nodes indicate the number of allelic differences.</p>
Genome assemblies: Horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae ST23/KL57 to Serratia marcescens
<p>Hypervirulent Klebsiella pneumonia isolates express a range of virulence factors, often encoded on virulence plasmids. Occasionally these hypervirulent lineages acquire antimicrobial resistance genes rendering them multidrug-resistant. We describe the nosocomial transmission of a hypervirulent K. pneumoniae ST23/KL57 isolate carrying an NDM-1 and OXA-48 beta-lactamase among COVID-19 patients in a Danish university hospital. Furthermore, we characterize the plasmid structure and describe a within-patient horizontal transfer of a plasmid carrying a blaOXA-48 gene from K. pneumoniae ST23/KL57 to a Serratia marcescens isolate.</p>
The impact of antibiotic induction on virulence and antibiotic resistance in Klebsiella pneumoniae
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Nutrient conditions are primary drivers of bacterial capsule maintenance in Klebsiella
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Polyphasic characterization of carbapenem-resistant Klebsiella pneumoniae clinical isolates suggests vertical transmission of the blaKPC-3 gene
<p>Optical DNA mapping (ODM) data related to the study, presented in figures 2-6 in the paper.</p>
Computer-Aided Drug Design (CADD): To Screen Potential Antibiotics Against Klebsiella Pneumoniae Beta-Lactamase Enzyme
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Identification and prioritization of novel therapeutic candidates against Glutamate racemase from Klebsiella pneumoniae
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IMPACT OF TEBIPENEM-PIVOXIL ON THE INTESTINAL MICROBIOTA AND ON ESTABLISHMENT OF COLONIZATION WITH CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE IN MICE
<p><span>Antimicrobial therapy has the</span><span> potential to cause unintended adverse effects by promoting antibiotic-resistant bacteria. Therefore, as new antibiotics are developed there is a need to understand their potential to disrupt the indigenous microbiota of the colon and promote colonization by pathogens. Tebipenem pivoxil (Teb-piv), the first oral carbapenem, has potent <em>in vitro</em> activity against <em>Enterobacterales</em> pathogens, but requires combination with an appropriate β-lactamase inhibitor to achieve activity against <em>Klebsiella pneumoniae</em> carbapenemase and metallo-β-lactamase (MBL)-producing carbapenem-resistant <em>Enterobacterales</em></span></p>
Data from: Clinical outcomes and safety of polymyxin B versus tigecycline combination therapy for pneumonia of carbapenem-resistant Klebsiella pneumoniae: A retrospective cohort study
<p><strong>Purpose:</strong> Infection by carbapenem-resistant <em>Klebsiella pneumoniae</em> (CRKP) has high mortality. There is no clear optimal therapeutic choice for pneumonia caused by CRKP. The aim of this study was to compare the clinical outcomes and safety of the standard doses of polymyxin B-based regimens vs tigecycline-based regimens and to identify risk factors for mortality.</p> <p><strong>Methods:</strong><strong> </strong>This retrospective cohort study included patients with pneumonia caused by CRKP for three years. The primary outcomes were 7-day bacterial eradication rate and 14- and 28-day all-cause mortality. The secondary outcome was incidence of acute kidney injury.</p> <p><strong>Results:</strong><strong> </strong>Seventy-three patients were included in this study, 29 in the<strong> </strong>polymyxin B-based combination therapy group and 44 in tigecycline-based combination therapy group. There were no significant differences between the two groups in terms of the 7-day bacterial eradication rate (31.0% vs 20.5%, <em>P</em>=0.409), the 14-day all-cause mortality (37.9% vs 22.7%, <em>P</em>=0.160), and the incidence of acute kidney injury (14.3% vs 6.8%, <em>P</em>=0.526). The 28-day all-cause mortality in the polymyxin B-based therapy group was higher than in the tigecycline-based group (75.9% vs 45.5%, <em>P</em>=0.010). Binary logistic regression analysis revealed that male and previous use of carbapenems were independent factors associated with 28-day all-cause mortality for patients treated with polymyxin B (<em>P</em><0.05).</p> <p><strong>Conclusions:</strong><strong> </strong>Polymyxin B-based combination therapy at the standard dose should be used with caution for patients with CRKP-induced pneumonia, especially for men who used carbapenems prior to CRKP detection.</p>
Live and dead cells in strong and weak biofilms of Klebsiella pneumoniae
<p>Video of CLSM Z-stack of strong and weak biofilm showing the arrangement of live and dead cells inside the biofilm matrix. </p>
Figure 12: Theoretical Prediction of Imipenem Resistance in Klebsiella Pneumoniae (2020-2030)
<p><strong>Figure 12: Theoretical Prediction of Imipenem Resistance in Klebsiella Pneumoniae (2020-2030)</strong></p>
Figure 10: Antibiotic sensitivity and resistance pattern of Klebsiella pneumoniae
<p><strong>Figure 10: Antibiotic sensitivity and resistance pattern of Klebsiella pneumoniae </strong></p>
Figure 11: Theoretical Prediction of Meropenem Resistance in Klebsiella Pneumoniae 2020-2030
<p><strong>Figure 11: Theoretical Prediction of Meropenem Resistance in Klebsiella Pneumoniae 2020-2030</strong></p>
Broad-range capsule-dependent lytic Sugarlandvirus against Klebsiella sp.
<p>The genomic data of the three isolated Klebsiella phages, vB_Kpn_K7PH164C4, vB_Kpn_K30λ2.2 and vB_Kpl_K32PH164C1</p>
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.