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849 results for “Lactation”
Data from: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
<p>The astrocyte-neuron lactate shuttle hypothesis posits that glial-generated lactate is transported to neurons to fuel metabolic processes required for long-term memory. Although studies in vertebrates have revealed that lactate shuttling is important for cognitive function, it is uncertain if this form of metabolic coupling is conserved in invertebrates or is influenced by age. Lactate dehydrogenase (Ldh) is a rate-limiting enzyme that interconverts lactate and pyruvate. Here we genetically manipulated expression of <em>Drosophila</em> <em>melanogaster</em> lactate dehydrogenase (dLdh) in neurons or glia to assess the impact of altered lactate metabolism on invertebrate aging and long-term courtship memory at different ages. We also assessed survival, negative geotaxis, brain-neutral lipids (the core component of lipid droplets), and whole head metabolites. Both upregulation and downregulation of dLdh in neurons resulted in decreased survival and memory impairment with age. Glial downregulation of dLdh expression caused age-related memory impairment without altering survival, while upregulated glial dLdh expression lowered survival without disrupting memory. Both neuronal and glial dLdh upregulation increased neutral lipid accumulation. We provide evidence that altered lactate metabolism with age affects the tricarboxylic acid (TCA) cycle, 2-hydroxyglutarate (2HG), and neutral lipid accumulation. Collectively, our findings indicate that the direct alteration of lactate metabolism in either glia or neurons affects memory and survival but only in an age-dependent manner. </p>
ANION GAP OR SERUM LACTATE-IN SEARCH OF A BETTER PROGNOSTIC MARKER IN SEPSIS A CROSS-SECTIONAL STUDY IN A RURAL TERTIARY CARE HOSPITAL
<p>master data sheet</p>
Recombinant Human Prolactin for Lactation Induction
ClinicalTrials.gov study NCT00181610. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Global Effects of a Probiotic Strain on Lactating Women
ClinicalTrials.gov study NCT01124448. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Normal Saline Versus Ringer's Lactate for Initial Fluid Resuscitation in Sepsis
ClinicalTrials.gov study NCT07240701. IPD Sharing: YES. Countries: 1. Publications: 1.
Cabergoline for Lactation Inhibition After Early Second-Trimester Abortion or Pregnancy Loss
ClinicalTrials.gov study NCT06029673. IPD Sharing: YES. Countries: 1. Publications: 1.
User Acceptability of a Nicotine Lactate Delivery System (P3L)
ClinicalTrials.gov study NCT02643693. IPD Sharing: NO. Countries: 1. Publications: 1.
Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana
ClinicalTrials.gov study NCT04862975. IPD Sharing: YES. Countries: 1. Publications: 40.
Impact of Lactate-Containing Vaginal Lubricant on Sexual Dysfunction in Young Breast Cancer Survivors
ClinicalTrials.gov study NCT00981305. IPD Sharing: NO. Countries: 1. Publications: 1.
Ammonium Lactate Lotion 12% (Lac-hydrin®) and Halobetasol Propionate Ointment 0.05% (Ultravate®) in the Treatment and Maintenance of Psoriasis
ClinicalTrials.gov study NCT01111123. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Lactated Ringers With or Without Rectal Indomethacin to Prevent Post-ERCP Pancreatitis
ClinicalTrials.gov study NCT02641561. IPD Sharing: NO. Countries: 1. Publications: 19.
Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation
ClinicalTrials.gov study NCT03133767. IPD Sharing: NO. Countries: 1. Publications: 1.
Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Loss
ClinicalTrials.gov study NCT04701333. IPD Sharing: YES. Countries: 1. Publications: 2.
A Multicenter, Postmarketing Study Evaluating the Concentration of Cimzia® in Mature Breast Milk of Lactating Mothers
ClinicalTrials.gov study NCT02154425. IPD Sharing: Not stated. Countries: 3. Publications: 1.
The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women
ClinicalTrials.gov study NCT04285684. IPD Sharing: YES. Countries: 1. Publications: 6.
The Various Effects of Gaseous Albuterol on Serum Lactate
ClinicalTrials.gov study NCT02073747. IPD Sharing: NO. Countries: 1. Publications: 6.
Venous Lactate in Progression to Overt Septic Shock and Mortality in Non-elderly Sepsis Patients in Emergency Department
ClinicalTrials.gov study NCT01947127. IPD Sharing: NO. Countries: 1. Publications: 1.
High Volume Lactated Ringer's Solution and Pancreatitis
ClinicalTrials.gov study NCT02050048. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Recombinant Human Prolactin for Lactation Induction
ClinicalTrials.gov study NCT00181623. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Erlotinib Hydrochloride and Onalespib Lactate in Treating Patients With Recurrent or Metastatic EGFR-Mutant Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT02535338. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.