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623 results for “Lipid metabolism”
3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41
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Data from: Energy and lipid metabolism during direct and diapause development in a pierid butterfly
Diapause is a fundamental component of the life-cycle in the majority of insects living in environments characterized by strong seasonality. The present study addresses poorly understood associations and trade-offs between endogenous diapause duration, thermal sensitivity of development, energetic cost of development and cold tolerance. Diapause intensity, metabolic rate trajectories and lipid profiles of directly developing and diapausing animals were studied using pupae and adults of Pieris napi butterflies from a population for which endogenous diapause is well studied. Endogenous diapause was terminated after 3 months and termination required chilling. Metabolic and postdiapause development rates increased with diapause duration, while the metabolic cost of postdiapause development decreased, indicating that once diapause is terminated development proceeds at a low rate even at low temperature. Diapausing pupae had larger lipid stores than the directly developing pupae and lipids constituted the primary energy source during diapause. However, during diapause lipid stores did not decrease. Thus, despite lipid catabolism meeting the low energy costs of the diapausing pupae, primary lipid store utilization did not occur until the onset of growth and metamorphosis in spring. In line with this finding, diapausing pupae contained low amounts of mitochondria-derived cardiolipins, which suggests a low capacity for fatty acid β-oxidation. While ontogenic development had a large effect on lipid and fatty acid profiles, only small changes in these were seen during diapause. The data therefore indicate that the diapause lipidomic phenotype is built early, when pupae are still at high temperature, and retained until diapause post-diapause development.
Data from: Comparative transcriptomics reveals domestication-associated features of Atlantic salmon lipid metabolism
<p>Domestication of animals imposes strong targeted selection for desired traits but can also result in unintended selection due to new domestic environments. Atlantic salmon was domesticated in the 1970s and has subsequently been selected for faster growth in systematic breeding programmes. More recently, salmon aquaculture has replaced fish oils (FO) with vegetable oils (VO) in feed, radically changing the levels of essential long-chain polyunsaturated fatty acids (LC-PUFA). Our aim was to study the impact of domestication on metabolism and explore the hypothesis that the shift to VO-diets has unintentionally selected for a domestication-specific lipid metabolism. We conducted a 96-day feeding trial of domesticated and wild salmon fed diets based on FO, VO or phospholipids (PL), and compared transcriptomes and fatty acids in tissues involved in lipid absorption (pyloric caeca) and lipid turnover and synthesis (liver). Domesticated salmon had faster growth and higher gene expression in glucose and lipid metabolism compared to wild fish, possibly linked to differences in regulation of circadian rhythm pathways. Only the domesticated salmon increased expression of LC-PUFA synthesis genes when given VO. This transcriptome response difference was mirrored at the physiological level, with domesticated salmon having higher LC-PUFA but lower 18:3n-3 and 18:2n-6 levels. In line with this, the VO diet decreased growth rate in wild but not domesticated salmon. Our study revealed a clear impact of domestication on transcriptomic regulation linked to metabolism and suggests that unintentional selection in the domestic-environment has resulted in evolution of stronger compensatory mechanisms to a diet low in LC-PUFA. </p>
Data from: Transcriptome comparative analysis of two Camellia species reveals lipid metabolism during mature seed natural drying
Camellia seed oil has been used as high quality and healthy food for over two thousand years. Seed drying management effects oil quality and quantity. however, the molecular mechanisms of fatty acid biosynthesis and accumulation during the drying process remain unknown. In this study, the transcriptomes of Camellia meiocarpa and C. oleifera seed were characterized at five moisture content levels (10 - 50%) to identify the major processes and reveal genes affecting lipid metabolism in response to nature drying. We found a total of 111,156 unigenes by de novo assembled from RNA-Seq libraries of five moisture content levels during after-ripening of C. meiocarpa (74,016) and C. oleifera (76,374). Ten pathways were closely linked to changes in oil content and composition with 244 genes involved in fatty acid synthesis and accumulation. Gene Ontology enrichment of differentially expressed genes (DEGs) indicated that fatty acid synthesis and accumulation are essential in C. meiocarpa while fatty acid accumulation in C. oleifera during nature drying process. Comparative analyses of DEGs between any two consecutive moisture contents, identified six and three key unigenes in C. Meiocarpa and C. oleifera seeds, respectively, and one additional unigene responsible for the difference between the two species' fatty acid synthesis and accumulation. Natural drying has improved the quality and quantity of the camellia seed oil. The study provided: a) global transcriptional profiles at five moisture content levels during seed nature drying, b) insights into highlighting transcripts putatively involved in the regulation of the gene expression program and in specific processes likely essential for lipid metabolism, and c) an opportunity to discovering genes associated with oil seed quantity and quality improvement for the studied two camellia species.
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2
<p>Original figures for the following publication: </p> <p>The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2</p> <table align="left"> <tbody> <tr> <td> <p><em>Cells </em><strong>2022</strong>, <em>11</em>, x. https://doi.org/10.3390/xxxxx</p> </td> </tr> </tbody> </table>
Transcriptome analysis and functional study of phospholipase A2 in Galleria mellonella larvae lipid metabolism in response to envenomation by an ectoparasitoid, Iseropus kuwanae
<p>The file is the raw data of "Transcriptome analysis and functional study of phospholipase A2 in <em>Galleria mellonella</em> larvae lipid metabolism in response to envenomation by an ectoparasitoid, <em>Iseropus kuwanae</em>".</p>
Membrane lipid metabolism, heat shock response, and energy costs mediate the interaction between acclimatization and heat hardening response
<p>Thermal plasticity on different timescales, including acclimation/acclimatization and heat hardening response – a rapid adjustment for thermal tolerance after a nonlethal thermal stress, can interact on organisms to improve the resilience to thermal stress. However, little is known about the physiological mechanisms mediating this interaction. To investigate underpinnings of heat hardening responses after acclimatization in warm season, we measured thermal tolerance plasticity, compared transcriptomic and metabolomic changes after heat hardening at 33 or 37<sup>o</sup>C followed by recovery of 3 h or 24 h in an intertidal bivalve <i>Sinonovacula constricta</i>. The clams showed explicit heat hardening responses after acclimatization in warm season. The higher inducing temperature (37<sup>o</sup>C) caused a less effective heat hardening effect than the inducing temperature that was closer to seasonal maximum temperature (33<sup>o</sup>C). Metabolomic analysis highlighted the elevated contents of membrane glyceropholipids in all heat hardened clams, which may help to maintain structure and function of membrane. Heat shock proteins (HSPs) tended to be up-regulated after heat hardening at 37<sup>o</sup>C but not at 33<sup>o</sup>C, indicating that there was no complete dependency of heat hardening effects on up-regulated HSPs. Enhanced energy metabolism and decreased energy reserves were observed after heat hardening at 37<sup>o</sup>C, suggesting more energy costs during exposure to higher inducing temperature which may restrict heat hardening effects. These results highlighted the mediating role of membrane lipid metabolism, heat shock responses and energy costs in the interaction of heat hardening response and seasonal acclimatization, and benefit the mechanistic understanding of evolutionary change and thermal plasticity during global climate change.</p>
Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation
<p>During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multiomics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation. Data reveal that MK differentiation is driven by an increased fatty acyl import and <em>de novo</em> lipid synthesis, resulting in an anionic membrane phenotype. Pharmacological perturbation of fatty acid import and phospholipid synthesis blocked membrane remodeling and directly reduced MK polyploidization and proplatelet formation resulting in thrombocytopenia. The anionic lipid shift during megakaryopoiesis was paralleled by lipid-dependent relocalization of the scaffold protein CKIP-1 and recruitment of the kinase CK2α to the plasma membrane, which seems to be essential for sufficient platelet biogenesis. Overall, this study provides a framework to understand how the MK lipidome is altered during maturation and the impact of MK membrane lipid remodeling on MK kinase signaling involved in thrombopoiesis.</p>
Impact of Consumption of Beta-glucans on the Intestinal Microbiota and Glucose and Lipid Metabolism
ClinicalTrials.gov study NCT02041104. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function
ClinicalTrials.gov study NCT03503084. IPD Sharing: NO. Countries: 1. Publications: 7.
Effect of L-citrulline and HIIT on Arterial Stiffness, Body Composition, and Lipid Profile in Adolescents with Steatosis Associated with Metabolic Dysfunction (MASLD)
ClinicalTrials.gov study NCT05778266. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Tomato Consumption on Steatosis, Intestinal Function and Glucose and Lipid Metabolism in Subjects With NAFLD
ClinicalTrials.gov study NCT06389851. IPD Sharing: NO. Countries: 1. Publications: 4.
Effects of 2 Initial Standard Antiretroviral Combinations Therapies on Lipid Metabolism
ClinicalTrials.gov study NCT00759070. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effects of Dietary Fructose on Glucose and Lipid Metabolism in Healthy Human Subjects
ClinicalTrials.gov study NCT01021969. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Postprandial Lipid Metabolism in Familial Hypercholesterolaemia:Effects of Fish Oils
ClinicalTrials.gov study NCT01577056. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Impact of 100mL Lipid Emulsion for Intravenous for Suppression of Myocardial Glucose Metabolism in 18F-FDG PET/CT
ClinicalTrials.gov study NCT04437927. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of n-3 Fatty Acids and Fish on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Metabolism
ClinicalTrials.gov study NCT01768429. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Examination of the Effects of Chromium Levels on Glucose Metabolism, Lipid Metabolism, Morbidity and Mortality Rates in Patients Followed in Intensive Care Unit
ClinicalTrials.gov study NCT06334042. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Comparative Effects of Chronic Treatment With Olanzapine and Risperidone on Glucose and Lipid Metabolism
ClinicalTrials.gov study NCT00287820. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effects on Lipid Metabolism of Olive Extracts Rich in Polyphenols
ClinicalTrials.gov study NCT03584581. IPD Sharing: NO. Countries: 1. Publications: 10.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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