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623 results for “Lipid metabolism”
Raw data to accompany the manuscript 'Data for Engineering Lipid Metabolism of Chinese Hamster Ovary (CHO) Cells for Enhanced Recombinant Protein Production' published in the Journal Data in Brief
<p>This repository consists of the raw western blot, microscopy and mass spectrometry data to accompany the manuscript 'Data for Engineering Lipid Metabolism of Chinese Hamster Ovary (CHO) Cells for Enhanced Recombinant Protein Production' published in the Journal Data in Brief and associated with the article '<a href="https://www.ncbi.nlm.nih.gov/pubmed/31805379">Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production</a>' published in the journal Metabolic Engineering (see DOI: 10.1016/j.ymben.2019.11.007). </p> <p>The western blot raw file is associated with Figure 1a and 1b of the Data in Brief manuscript.</p> <p>The confocal microscopy raw image files (x3) are associated with Figure 1c of the Data in Brief manuscript.</p> <p>The mass spectrometry files are the raw data that refers to the samples presented in Figure 5 of the Data in Brief manuscript. Files are labelled as in the Data in Brief and Metabolic Engineering manuscripts. The file name structures is as follows;</p> <p>CHO-Controlpoolai</p> <p>Where 'a' represents replicate 'a' of three biological replicates and 'i' refers to mass spectrometry technical analysis 1 of 3 technical analyses of each replicate (thus for each cell pool or line there are three biological replicates that are each analysed in triplicate such that there are 9 raw mass spectrometry files for each cell pool or line).</p> <p>All the mass spectrometry files are found in the compressed (zip) file named mass_spectrometry_raw_files_archive.zip</p>
Pea aphid winged and wingless males exhibit reproductive, gene expression, and lipid metabolism differences
<p><span>Alternative, intraspecific phenotypes offer an opportunity to identify the mechanistic basis of differences associated with distinctive life-history strategies. Wing dimorphic insects, in which both flight-capable and flight-incapable individuals occur in the same population, are particularly well-studied in terms of why and how the morphs trade-off flight for reproduction. Yet despite a wealth of studies examining the differences between female morphs, little is known about male differences, which could arise from different causes than those acting on females. Here we examined reproductive, gene expression, and biochemical differences between pea aphid (<em>Acyrthosiphon pisum</em>) winged and wingless males. We find that winged males are competitively superior in one-on-one mating circumstances, but wingless males reach reproductive maturity faster and have larger testes. We suggest that males </span><span>tradeoff increased local matings with concurrent possible inbreeding for outbreeding and increased ability to find mates. At the mechanistic level, differential gene expression between the morphs revealed a possible role for activin and insulin signaling in morph differences; it also highlighted genes not previously identified as being functionally important in wing polymorphism, such as genes likely involved in sperm production. Further, we find that winged males have higher lipid levels, consistent with their use as flight fuel, but we find no consistent patterns of different levels of activity among five enzymes associated with lipid biosynthesis. Overall, our analyses provide evidence that winged versus wingless males exhibit differences at the reproductive, biochemical, and gene expression levels, expanding the field's understanding of the functional aspects of morph differences.</span></p>
The data for: What can be lost? Genomic perspective on the lipid metabolism of Mucoromycota
<div> <h3><a href="https://static-content.springer.com/esm/art%3A10.1186%2Fs43008-023-00127-4/MediaObjects/43008_2023_127_MOESM1_ESM.xlsx"><strong>Additional file 1:</strong></a></h3> <div> <p>Spreadsheet with gene names, protein accessions and list of analysed fungal assemblies.</p> </div> </div> <div> <h3><a href="https://static-content.springer.com/esm/art%3A10.1186%2Fs43008-023-00127-4/MediaObjects/43008_2023_127_MOESM2_ESM.txt"><strong>Additional file 2:</strong></a></h3> <div> <p>Phylogenetic trees of all proteins.</p> </div> </div>
Dataset for "Diets supplemented with Saccharina latissima influence the expression of genes related to lipid metabolism and oxidative stress modulating rainbow trout (Oncorhynchus mykiss) fillet composition" (doi.org/10.1016/j.fct.2020.111332)
<p>Dataset corresponding to the following article:</p> <p>Ferreira, M., Larsen, B.K., Granby, K., Cunha, S.C., Monteiro, C., Fernandes, J.O., Nunes, M.L., Marques, A., Dias, J., Cunha, I., Castro, L.F.C., Valente, L.M.P., 2020. Diets supplemented with <em>Saccharina latissima </em>influence the expression of genes related to lipid metabolism and oxidative stress modulating rainbow trout (<em>Oncorhynchus mykiss</em>) fillet composition. Food Chem. Toxicol. 140, 111332. <a href="https://doi.org/10.1016/j.fct.2020.111332">https://doi.org/10.1016/j.fct.2020.111332</a></p>
Data from: Balanced replacement of fish meal with Hermetia illucens meal allows efficient hepatic nutrient metabolism and increased fillet lipid quality in gilthead sea bream (Sparus aurata) juveniles
<p>In the present study, gilthead sea bream (<em>Sparus aurata</em>) juveniles were reared using sustainable feeds containing insect meal from <em>Hermetia illucens</em> larvae and poultry by-products meal. Proteomics and Proton Nuclear Magnetic Resonance-based metabolomics analysis were used to assess the metabolic impact of tested dietary formulations in sea bream liver, whereas the composition of muscle fillet was characterized by means of metabolomics and gas chromatography of fatty acids methyl esters. Replacing fish meal with insect meal in a 5% fish meal diet did not substantially alter metabolism of dietary nutrients, leading to small but statistically detectable effects solely on lauric acid content of sea bream fillet, and few alterations in some markers of immune response, such as leukocyte elastase inhibitor-like, granzyme B (G,H)-like, and two associated ortholog groups namely serpin B, and chymase). Liver morphology confirmed the absence of structural damage or inflammation in the insect meal-fed group, which showed a lower amount of hepatic lipid deposition and accumulation, too.</p>
Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER St
ClinicalTrials.gov study NCT04216589. IPD Sharing: YES. Countries: 2. Publications: 2.
Pea aphid winged and wingless males exhibit reproductive, gene expression, and lipid metabolism differences
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Germline proliferation trades off with lipid metabolism in Drosophila
<p>Little is known about the metabolic basis of life-history trade-offs but lipid stores seem to play a pivotal role. During reproduction, an energetically highly costly process, animals mobilize fat reserves. Conversely, reduced or curtailed reproduction promotes lipid storage in many animals. Systemic signals from the gonad seem to be involved: <em>C. elegans</em> lacking germline stem cells display endocrine changes, have increased fat stores and are long-lived. Similarly, germline-ablated <em>D. melanogaster </em>exhibit major somatic physiological changes, but whether and how germline loss affects lipid metabolism remains largely unclear. Here we show that germline-ablated flies have profoundly altered energy metabolism at the transcriptional level and store excess fat as compared to fertile flies. Germline activity thus constrains or represses fat accumulation, and this effect is conserved between flies and worms. More broadly, our findings confirm that lipids represent a major energetic currency in which costs of reproduction are paid.</p>
3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41
<p class="MsoNormal"><span>3-(4-hydroxy-3-methoxyphenyl) propionic acid (HMPA) is a metabolite produced by the gut microbiota through the conversion of 4-hydroxy-3-methoxycinnamic acid (HMCA), which is a widely distributed hydroxycinnamic acid-derived metabolite found abundantly in plants. Several beneficial effects of HMPA have been suggested, such as antidiabetic properties, anticancer activities, and cognitive function improvement, in animal models and human studies. However, the intricate molecular mechanisms underlying the bioaccessibility and bioavailability profile following HMPA intake and the substantial modulation of metabolic homeostasis by HMPA require further elucidation. In this study, we effectively identified and characterized HMPA-specific GPR41 receptor, with greater affinity than HMCA. The activation of this receptor plays a crucial role in the anti-obesity effects and improvement of hepatic steatosis by stimulating the lipid catabolism pathway. For the improvement of metabolic disorders, our results provide insights into the development of functional foods, including HMPA, and preventive pharmaceuticals targeting GPR41.</span></p>
Lipid metabolism, fatty acid composition and meat quality in broilers supplemented with increasing levels of defrosted black soldier fly larvae
<p>Dataset for the experiment to evaluate the effects of increasing levels of whole black soldier fly larvae (BSFL) in broiler diets on lipid metabolism, fatty acid composition, and meat quality of birds. Chicks received the whole BSFL at 10%, 20%, or 30% of the feed intake of control chickens that received no BSFL but only age-specific diets. <a href="https://doi.org/10.3920/JIFF2022.0125">https://doi.org/10.3920/JIFF2022.0125</a></p>
Lipidomic datasets for: Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
<p>Transmembrane protein 135 (TMEM135) is thought to participate in the cellular response to increased intracellular lipids yet no defined molecular function for TMEM135 in lipid metabolism has been identified. In this study, we performed a lipid analysis of tissues from <em>Tmem135</em> mutant mice and found striking reductions of docosahexaenoic acid (DHA) across all <em>Tmem135</em> mutant tissues, indicating a role of TMEM135 in the production of DHA. Since all enzymes required for DHA synthesis remain intact in <em>Tmem135</em> mutant mice, we hypothesized that TMEM135 is involved in the export of DHA from peroxisomes. The <em>Tmem135</em> mutation likely leads to the retention of DHA in peroxisomes, causing DHA to be degraded within peroxisomes by their beta-oxidation machinery. This may lead to generation or alteration of ligands required for the activation of peroxisome proliferator-activated receptor a (PPARa) signaling, which in turn could result in increased peroxisomal number and beta-oxidation enzymes observed in <em>Tmem135</em> mutant mice. We confirmed this effect of PPARa signaling by detecting decreased peroxisomes and their proteins upon genetic ablation of <em>Ppara</em> in <em>Tmem135</em> mutant mice. Using <em>Tmem135</em> mutant mice, we also validated the protective effect of increased peroxisomes and peroxisomal beta-oxidation on the metabolic disease phenotypes of leptin mutant mice which has been observed in previous studies. Thus, we conclude that TMEM135 has a role in lipid homeostasis through its function in peroxisomes.</p>
Chronic hyperadiponectinemia induced by transgenic overexpression increases plasma exosomes without significantly improving glucose and lipid metabolism
<p><span>The fat</span><span>-derived factor, adiponectin, is considered a salutary circulating factor.</span> <span>We recently demonstrated that native adiponectin binds T-cadherin and promotes intracellular biogenesis and secretion of the exosome. Exosomes play important roles in various aspects of homeostasis, including glucose and energy metabolism. However, it remains unclear whether and how the promotion of exosome production by adiponectin <em>in vivo</em> is beneficial for glucose and lipid metabolism. In the present study, overexpression of human adiponectin in mice resulted in an increased number of circulating exosomes, but it did not significantly improve glucose metabolism, change body weights, or change triglyceride clearance under a high-fat diet. Multiple small doses of streptozotocin increased blood glucose and decreased triglyceride clearance similarly in both wild-type and transgenic mice. Thus, these results indicated that human adiponectin overexpression in mice increases plasma exosomes but does not significantly influence glucose and lipid metabolism.</span></p>
The Effect of E-EPA on Circulating LDL and Plasma Lipid Metabolism
ClinicalTrials.gov study NCT04152291. IPD Sharing: NO. Countries: 1. Publications: 2.
Effects of Testosterone Gel on Carbohydrate and Lipid Metabolism In Elderly Obese Men
ClinicalTrials.gov study NCT00365794. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects Of Exenatide On Liver Biochemistry, Liver Histology And Lipid Metabolism In Patients With Fatty Liver Disease
ClinicalTrials.gov study NCT00529204. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of PCSK9 Inhibition by Evolocumab on Postprandial Lipid Metabolism in Type 2 Diabetes
ClinicalTrials.gov study NCT02948777. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Data from: Enhanced resistance to <em>Listeria</em> infection in mice surviving sepsis: The role of lipid metabolism and myeloid cell reprogramming
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Germline proliferation trades off with lipid metabolism in Drosophila
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Chronic hyperadiponectinemia induced by transgenic overexpression increases plasma exosomes without significantly improving glucose and lipid metabolism
Open the record for dataset details and reuse information.
Lipidomic datasets for: Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
Open the record for dataset details and reuse information.
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