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95 results for “Local staging”
Data from: High genetic variation in resting stage production in a metapopulation: is there evidence for local adaptation?
Local adaptation is a key process for the maintenance of genetic diversity and population diversification. A better understanding of the mechanisms that allow (or prevent) local adaptation constitutes a key in apprehending how and at what spatial scale it occurs. The production of resting stages is found in many taxa and reflects an adaptation to outlast adverse environmental conditions. Daphnia magna (Crustacea) can alternate between asexual and sexual reproduction, the latter being linked to dormancy, as resting stages can only be produced sexually. In this species, on a continental scale, resting stage production is locally adapted, i.e. it is induced when the photoperiod indicates the imminence of habitat deterioration. Here, we aimed to explore whether selection is strong enough to maintain local adaptation at a scale of a few kilometers. We assessed life history traits of 64 D. magna clones originating from 11 populations of a meta-population with permanent and intermittent pool habitats. We found large within- and between-population variation for all dormancy-related traits, but no evidence for the hypothesised higher resting stage production in animals from intermittent habitats. We discuss how gene flow, founder events or other forms of selection might interfere with the process of local adaptation.
Laparoscopic Staging for Locally Advanced Gastric Cancer in Chinese Patients
ClinicalTrials.gov study NCT02172690. IPD Sharing: Not stated. Countries: 1. Publications: 1.
FES (16α-[18F]-Fluoro-17β-estradiol)-PET: Towards a New Standard to Stage Locally Advanced and Recurrent, Estrogen Receptor Positive (ER+) Breast Cancer? Pilot Study to Compare [18F]FES-PET and [18F]F
ClinicalTrials.gov study NCT03726931. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Study of Micrometastases in Patients With Stage I or Stage II Localized Colon Cancer That Can Be Removed by Surgery
ClinicalTrials.gov study NCT01097265. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sentinel Node Localization and Staging with Low Dose Superparamagnetic Iron Oxide
ClinicalTrials.gov study NCT05359783. IPD Sharing: NO. Countries: 1. Publications: 6.
Characterization of Circulating Tumor Cells (CTC-s) in Patients With Locally Advanced or Metastatic Stage IV Breast Cancer
ClinicalTrials.gov study NCT01048918. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Application of 18F-FDG PET/MRI for Initial Staging in Locally Advanced Nasopharyngeal Carcinoma
ClinicalTrials.gov study NCT06947759. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Multimodality Treatment Approach to Patients With Inflammatory Cancer of the Breast and Locally Advanced Non-Inflammatory Stage III Breast Cancer and Stage IV Breast Cancer
ClinicalTrials.gov study NCT00001193. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Study in Participants With Early-Stage or Locally Advanced Human Epidermal Growth Factor Receptor (HER) 2-Positive and Estrogen Receptor/Progesterone Receptor Negative Breast Cancer to Evaluate the Ef
ClinicalTrials.gov study NCT04629846. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Peculiarities of Pain in Patients With Gunshot Wounds Depending on the Localization of the Wound at the Stages of Treatment
ClinicalTrials.gov study NCT05489029. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Study to Evaluate the Efficacy and Safety of HLX11 vs. EU-Perjeta® in the Neoadjuvant Therapy of HER2-Positive and HR-Negative Early-stage or Locally Advanced Breast Cancer
ClinicalTrials.gov study NCT05346224. IPD Sharing: Not stated. Countries: 4. Publications: 1.
A Study of Lazertinib as Consolidation Therapy in Patients With Locally Advanced, Unresectable, EGFR-Mutant Non-Small Cell Lung Cancer (Stage III) Following Chemoradiation Therapy
ClinicalTrials.gov study NCT05338619. IPD Sharing: NO. Countries: 1. Publications: 2.
Nivolumab and Ipilimumab With or Without Local Consolidation Therapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT03391869. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Trial of RNActive®-Derived Cancer Vaccine and Local Radiation in in Stage IV Non Small Cell Lung Cancer (NSCLC)
ClinicalTrials.gov study NCT01915524. IPD Sharing: Not stated. Countries: 3. Publications: 2.
Dendritic Cell Therapy With CD137L-DC-EBV-VAX in Locally Advanced Stage IV or Locally Recurrent/Metastatic Nasopharyngeal Carcinoma
ClinicalTrials.gov study NCT03282617. IPD Sharing: NO. Countries: 1. Publications: 3.
Multi-parametric MRI in Patients Suspected for Muscle Invasive Bladder Cancer: a New Local Staging Paradigm
ClinicalTrials.gov study NCT05779631. IPD Sharing: YES. Countries: 1. Publications: 1.
VXM01 Phase I Dose Escalation Study in Patients With Locally Advanced, Inoperable and Stage IV Pancreatic Cancer
ClinicalTrials.gov study NCT01486329. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study to Describe the Diagnostic and Therapeutic Path of Patients with NSCLC in Early Stage and Locally Advanced
ClinicalTrials.gov study NCT06467383. IPD Sharing: NO. Countries: 1. Publications: 29.
Gene-Modified T Cells, Vaccine Therapy, and Nivolumab in Treating Patients With Stage IV or Locally Advanced Solid Tumors Expressing NY-ESO-1
ClinicalTrials.gov study NCT02775292. IPD Sharing: NO. Countries: 1. Publications: 1.
Bevacizumab Plus Fluorouracil and Leucovorin in Treating Patients With Locally Advanced or Metastatic Stage IV Colorectal Cancer That Has Progressed After Standard Chemotherapy
ClinicalTrials.gov study NCT00066846. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.