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1,257 results for “METHYLATION PROFILE”
DNA methylation profiling and genomic analysis in 20 children with short stature who were born small-for-gestational age
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DNA methylation profiles suggest intergenerational transfer of maternal effects
<p>The view of maternal effects (non-genetic maternal environmental influence on offspring phenotype) has changed from one of distracting complications in evolutionary genetics to an important evolutionary mechanism for improving offspring fitness. Recent studies have shown that maternal effects act as an adaptive mechanism to prepare offspring for stressful environments. Although research into the magnitude of maternal effects is abundant, the molecular mechanisms of maternal influences on offspring phenotypic variation are not fully understood. Despite recent work identifying DNA methylation as a potential mechanism of non-genetic inheritance, currently proposed links between DNA methylation and parental effects are indirect and primarily involve genomic imprinting. We combined a factorial breeding design and gene-targeted sequencing methods to assess inheritance of methylation during early life stages at 14 genes involved in growth, development, metabolism, stress response and immune function of Chinook salmon (<i>Oncorhynchus tshawytscha</i>). We found little evidence for additive or non-additive genetic effects acting on methylation levels during early development; however, we detected significant maternal effects. Consistent with conventional maternal effect data, maternal effects on methylation declined through development and were replaced with non-additive effects when offspring began exogenous feeding. We mapped methylation at individual CpG sites across the selected candidate genes to test for variation in site-specific methylation profiles and found significant maternal effects at selected CpG sites that also declined with development stage. While intergenerational inheritance of methylated DNA is controversial, we show that CpG-specific methylation may function as an underlying molecular mechanism for maternal effects, with important implications for offspring fitness.</p>
Profile Of Methylation and Gene Expression Of Gene ADRB3 And Effects Of Folate Intake
ClinicalTrials.gov study NCT02846025. IPD Sharing: YES. Countries: 0. Publications: 1.
DNA methylation profiles suggest intergenerational transfer of maternal effects
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Global DNA methylation profiling of radiation-induced rat mammary carcinomas
To investigate DNA methylation patterns in rat mammary carcinomas induced by ionizing radiation. DNA methylation patterns were analyzed in radiation-induced rat mammary carcinomas and normal mammary gland tissues using CpG island microarray.
Epigenome-wide DNA methylation profiling in CBMCs
GEO Series GSE190908. Homo sapiens. 155 samples. Type: Methylation profiling by genome tiling array.
DNA methylation profile in chronic myelomonocytic leukemia associates with distinct clinical, biological and genetic features
GEO Series GSE105420. Homo sapiens. 76 samples. Type: Methylation profiling by array.
Comparison of DNA methylation profilings between hESCs and hiPSCs
GEO Series GSE42448. Homo sapiens. 70 samples. Type: Methylation profiling by array.
Whole genome methylation profiling in developing and developed Zebrafish
GEO Series GSE52110. Danio rerio. 11 samples. Type: Methylation profiling by high throughput sequencing.
Genome-wide DNA methylation profiles of 20 paired (normal and varicose) vein samples from the patients with varicose vein disease.
GEO Series GSE68319. Homo sapiens. 20 samples. Type: Methylation profiling by genome tiling array.
Seminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines (methylation data).
GEO Series GSE56382. Homo sapiens. 2 samples. Type: Methylation profiling by genome tiling array.
DNA methylation profiling to determine the primary sites of metastatic cancers using formalin-fixed paraffin-embedded tissues [ValidationSet]
GEO Series GSE231969. Homo sapiens. 215 samples. Type: Methylation profiling by high throughput sequencing.
A comparison of genome-wide DNA methylation profiles between Tibetan and Yorkshire pigs
GEO Series GSE114779. Sus scrofa. 16 samples. Type: Methylation profiling by high throughput sequencing.
Genome-wide methylation profile of mitochondrial DNA across bovine preimplantation development
GEO Series GSE230476. Bos taurus. 18 samples. Type: Methylation profiling by high throughput sequencing.
Methylation data from nine tissues from GTEx samples profiled with Infinium HumanMethylationEPIC BeadChip
GEO Series GSE213478. Homo sapiens. 987 samples. Type: Methylation profiling by array.
DNA methylation profiling of lung transplant recipients
GEO Series GSE253562. Homo sapiens. 92 samples. Type: Methylation profiling by high throughput sequencing.
Papillary Tumor of the Pineal Region: analysis of DNA methylation profiles and clinical outcomes in 76 cases
GEO Series GSE254031. Homo sapiens. 39 samples. Type: Methylation profiling by genome tiling array; Third-party reanalysis.
Profile of differential expression and DNA methylation status in choriodecidua of women affected with severe endometriosis [Gene Expression]
GEO Series GSE57733. Homo sapiens. 6 samples. Type: Expression profiling by array.
Methylation and Transcriptomic Profiling Reveals Short Term and Long Term Regulatory Responses in Polarized Macrophages [RNA-Seq]
GEO Series GSE273627. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
Progression Free Survival in Ovarian Cancer is Reflected in Epigenetic DNA-Methylation Profiles
GEO Series GSE25033. Homo sapiens. 20 samples. Type: Methylation profiling by array.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.