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91 results for “Magnetic Resonance Spectroscopy”
Inflammatory Biomarkers and Brain Metabolites, a Study Based on Magnetic Resonance Spectroscopy
ClinicalTrials.gov study NCT03052855. IPD Sharing: NO. Countries: 1. Publications: 1.
Postprandial IHL and IMCL Measured With Proton Magnetic Resonance Spectroscopy
ClinicalTrials.gov study NCT01709643. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Utilization of 31P-Nuclear Magnetic Resonance Spectroscopy to Monitor Brain Energy Deficit in Huntington Disease
ClinicalTrials.gov study NCT01696708. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Magnetic Resonance Spectroscopy to Evaluate Tourette s Syndrome
ClinicalTrials.gov study NCT00030953. IPD Sharing: Not stated. Countries: 1. Publications: 3.
New Magnetic Resonance Imaging and Spectroscopy Software in the Improvement of Image Quality
ClinicalTrials.gov study NCT03980535. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism
ClinicalTrials.gov study NCT00181259. IPD Sharing: NO. Countries: 1. Publications: 3.
Magnetic Resonance (MR) Spectroscopy of Breast Cancer Tissue
ClinicalTrials.gov study NCT00184210. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Data from: Investigation of discriminant metabolites in tamoxifen-resistant and choline kinase-alpha-downregulated breast cancer cells using 1H-nuclear magnetic resonance spectroscopy
Metabolites linked to changes in choline kinase-α (CK-α) expression and drug resistance, which contribute to survival and autophagy mechanisms, are attractive targets for breast cancer therapies. We previously reported that autophagy played a causative role in driving tamoxifen (TAM) resistance of breast cancer cells (BCCs) and was also promoted by CK-α knockdown, resulting in the survival of TAM-resistant BCCs. There is no comparative study yet about the metabolites resulting from BCCs with TAM-resistance and CK-α knockdown. Therefore, the aim of this study was to explore the discriminant metabolic biomarkers responsible for TAM resistance as well as CK-α expression, which might be linked with autophagy through a protective role. A total of 33 intracellular metabolites, including a range of amino acids, energy metabolism-related molecules and others from cell extracts of the parental cells (MCF-7), TAM-resistant cells (MCF-7/TAM) and CK-α knockdown cells (MCF-7/shCK-α, MCF-7/TAM/shCK-α) were analyzed by proton nuclear magnetic resonance spectroscopy (1H-NMRS). Principal component analysis (PCA) and partial least square discriminant analysis (PLS-DA) revealed the existence of differences in the intracellular metabolites to separate the 4 groups: MCF-7 cells, MCF-7/TAM cells, MCF-7-shCK-α cells, and MCF-7/TAM/shCK-α cells. The metabolites with VIP>1 contributed most to the differentiation of the cell groups, and they included fumarate, UA (unknown A), lactate, myo-inositol, glycine, phosphocholine, UE (unknown E), glutamine, formate, and AXP (AMP/ADP/ATP). Our results suggest that these altered metabolites would be promising metabolic biomarkers for a targeted therapeutic strategy in BCCs that exhibit TAM-resistance and aberrant CK-α expression, which triggers a survival and drug resistance mechanism.
Raw NMR data for Structural Studies of Alloyed and Nanoparticulate Transition Metal Dichalcogenides by Selenium-77 Solid-State Nuclear Magnetic Resonance Spectroscopy
<p>Raw NMR data for main text figures.</p>
Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease
ClinicalTrials.gov study NCT00933608. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Development of Magnetic Resonance Spectroscopy (MRS) Biomarkers of Tumor Metabolism (MK-0000-145)
ClinicalTrials.gov study NCT01138813. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Pilot Study Effect of Sulfasalazine on Glutamate Levels by(Magnetic Resonance Spectroscopy)MRS in Patients With Glioma
ClinicalTrials.gov study NCT01577966. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Feasibility of Magnetic Resonance Spectroscopy in Lung Cancer
ClinicalTrials.gov study NCT02497586. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Functional and Metabolic Imaging Using Magnetic Resonance Imaging and Spectroscopy
ClinicalTrials.gov study NCT00001591. IPD Sharing: Not stated. Countries: 1. Publications: 3.
7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle Events
ClinicalTrials.gov study NCT04507373. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Aging and the Mitochondrial Response to Exercise Training, Measured by Noninvasive 31P Magnetic Resonance Spectroscopy
ClinicalTrials.gov study NCT04799171. IPD Sharing: NO. Countries: 1. Publications: 0.
MRI and Magnetic Resonance Spectroscopy Imaging in Patients Receiving Dutasteride for Benign Prostatic Hypertrophy and Low-Risk Prostate Cancer
ClinicalTrials.gov study NCT00706966. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy
ClinicalTrials.gov study NCT00001874. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Magnetic Resonance Spectroscopy (MRS) Validation Study in Individuals With Nonalcoholic Fatty Liver Disease (NAFLD)
ClinicalTrials.gov study NCT00940537. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Investigation of discriminant metabolites in tamoxifen-resistant and choline kinase-alpha-downregulated breast cancer cells using 1H-nuclear magnetic resonance spectroscopy
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.