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ShareScore release 0.9.0
Dataset results
544 results for “Metabolic Diseases”
Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease
ClinicalTrials.gov study NCT03317444. IPD Sharing: NO. Countries: 8. Publications: 1.
PEMT-mediated phospholipid imbalance promotes age-associated metabolic dysfunction-associated steatotic liver disease progression
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Restoring hippocampal glucose metabolism rescues cognition across Alzheimer disease pathologies
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Single nucleotide polymorphisms related to vitamin D metabolism in patients with chronic obstructive pulmonary disease
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Data from: Chronic traffic noise increases food intake and alters gene expression associated with metabolism and disease in bats
<ol> <li>Anthropogenic noise exposure has deleterious effects on the foraging ecology of many animals. However, the effects of chronic anthropogenic noise on food intake and health condition in wildlife remain largely unknown.</li> <li>We tested whether traffic noise exposure over multiple days would change food intake and would have effects on the health of Asian particoloured bats. We broadcast traffic noise to the bats of two noise-exposure groups (group A, 5 bats; group C, 6 bats) and broadcast silence files to the bats of two control groups (group B, 5 bats; group D, 6 bats) for 12 days. We measured the changes in food intake, body weight, and concentration of faecal triiodothyronine (T3) and thyroxine (T4) in groups A and B. We compared the transcriptional profiles in brain, kidney and liver tissues between bats in groups C and D.</li> <li>The bats exposed to traffic noise had a significantly higher daily food intake and a significantly greater body weight than bats in control group during the period of playback. Faecal T3 and T4 were higher in the noise-exposure group after playback had been on for more than one day.</li> <li>We found a total of 169 differentially expressed genes (DEGs) between noise-exposure and control groups. Some DEGs related to stress response were up-regulated in the bats exposed to noise. The 169 DEGs were mainly enriched in Gene Ontology (GO) terms associated with metabolism, fundamental cellular processes, stress response and immune response. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways affected by noise exposure were linked with metabolism, disease, apoptosis, autophagy, phagosome and ribosome.</li> </ol> <p><i>Synthesis and applications</i>. Our results suggest that bats exposed to chronic traffic noise while roosting may need more energetic intake and have a greater motivation to forage than others not exposed to noise, probably as a result of a stress response. Furthermore, chronic traffic noise may increase the risk of metabolic dysregulation, immune disorders, and other diseases. Management measures for reducing noise disturbance, for example, implementing sound barriers, are essential.</p>
Supplemental files associated with the the manuscript "Genetic screening and metabolomics identify glial adenosine metabolism as a therapeutic target in Parkinson's disease"
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Cardio-metabolic Diseases in Immigrants and Ethnic Minorities: From Epidemiology to New Prevention Strategies
ClinicalTrials.gov study NCT06131411. IPD Sharing: NO. Countries: 1. Publications: 1.
Randomized Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease
ClinicalTrials.gov study NCT04626323. IPD Sharing: NO. Countries: 1. Publications: 59.
Korean Health Screening-Based Metabolic Dysfunction-Associated Steatotic Liver Disease Registry
ClinicalTrials.gov study NCT06843421. IPD Sharing: NO. Countries: 1. Publications: 10.
Long-term Investigation of Resveratrol on Fat Metabolism in Obese Men With Nonalcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT01446276. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effectiveness of Acetazolamide for Reversal of Metabolic Alkalosis in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients
ClinicalTrials.gov study NCT01627639. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Health Benefits of Whole Grain Oats in Population at Risk of Cardio-metabolic Disease
ClinicalTrials.gov study NCT01925365. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Dietary Fructose: a Metabolic Switch in Pediatric Obesity-related Disease.
ClinicalTrials.gov study NCT06365567. IPD Sharing: NO. Countries: 1. Publications: 11.
The Effects of Beta-glucan Enriched Oatcake Consumption on Metabolic Disease Risk Factors
ClinicalTrials.gov study NCT02615444. IPD Sharing: Not stated. Countries: 1. Publications: 4.
ALD-101 Adjuvant Therapy of Unrelated Umbilical Cord Blood Transfusion (UCBT) in Patients With Inherited Metabolic Diseases
ClinicalTrials.gov study NCT00654433. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Effect of Sinbiotic With Multispecies Probiotics on Liver Parameters Liver Enzymes, Ultrasound, Elastography and Adipokines in Same Cases) in Patients With Metabolic Associated Steatotic Liver Disease
ClinicalTrials.gov study NCT07025980. IPD Sharing: NO. Countries: 1. Publications: 12.
Multicenter Analysis of Genomic and Metabolic Data of Neonatal Genetic Diseases
ClinicalTrials.gov study NCT06183138. IPD Sharing: NO. Countries: 1. Publications: 8.
Interdisciplinary Intervention in Patients With Obesity and Other Metabolic Diseases
ClinicalTrials.gov study NCT02573688. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Fiber Metabolism in Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT04459156. IPD Sharing: NO. Countries: 1. Publications: 1.
Genetic and Metabolic Disease in Children
ClinicalTrials.gov study NCT02650622. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.