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565 results for “Metabolic response;”
Multi-omics analysis reveals the glycolipid metabolism response mechanism in the liver of Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus) under hypoxia stress
<p><span><b>Background: </b>Dissolved oxygen (DO) in the water is a vital abiotic factor in aquatic animal farming. A hypoxic environment affects the growth, metabolism, and immune system of fish. Glycolipid metabolism is a vital energy pathway under acute hypoxic stress, and it plays a significant role in the adaptation of fish to stressful environments. In this study, we used multi-omics integrative analyses to explore the mechanisms of hypoxia adaptation in Genetically Improved Farmed Tilapia (GIFT, <i>Oreochromis niloticus</i>). </span></p> <p><span><b>Results:</b><b> </b>The 96 h median lethal hypoxia (96h-LH50) for GIFT was determined by linear interpolation. We established control (DO: 5 mg/L) groups (CG) and hypoxic stress (96h-LH50) groups (HG) and extracted liver tissues for high-throughput transcriptome and metabolome sequencing. A total of 581 differentially expressed (DE) genes and 1250 DE metabolites were detected between CG and HG, and were annotated using tools at the KEGG database. We verified the transcript levels of eight DE genes by quantitative real-time PCR.</span></p> <p><span><b>Conclusions: </b>Analyses of essential glycolipid metabolism pathways of GIFT under hypoxia stress showed that, after 96 h of hypoxia stress, lipid metabolism became the primary metabolic pathway in GIFT. Our findings reveal the changes in metabolites and gene expression that occur under hypoxia stress, and shed light on the regulatory pathways that function under such conditions. Ultimately, this information will be useful to devise strategies to decrease the damage caused by hypoxia stress in farmed fish.</span></p>
Data from: Does metabolism constrain bird and mammal ranges and predict shifts in response to climate change?
Mechanistic approaches for predicting the ranges of endotherms are needed to forecast their responses to environmental change. We test whether physiological constraints on maximum metabolic rate and the factor by which endotherms can elevate their metabolism (metabolic expansibility) influence cold range limits for mammal and bird species. We examine metabolic expansibility at the cold range boundary (MECRB) and whether species' traits can predict variability in MECRB and then use MECRB as an initial approach to project range shifts for 210 mammal and 61 bird species. We find evidence for metabolic constraints: the distributions of metabolic expansibility at the cold range boundary peak at similar values for birds (2.7) and mammals (3.2). The right skewed distributions suggest some species have adapted to elevate or evade metabolic constraints. Mammals exhibit greater skew than birds, consistent with their diverse thermoregulatory adaptations and behaviors. Mammal and bird species that are small and occupy low trophic levels exhibit high levels of MECRB. Mammals with high MECRB tend to hibernate or use torpor. Predicted metabolic rates at the cold range boundaries represent large energetic expenditures (>50% of maximum metabolic rates). We project species to shift their cold range boundaries poleward by an average of 3.9° latitude by 2070 if metabolic constraints remain constant. Our analysis suggests that metabolic constraints provide a viable mechanism for initial projections of the cold range boundaries for endotherms. However, errors and approximations in estimating metabolic constraints (e.g., acclimation responses) and evasion of these constraints (e.g., torpor/hibernation, microclimate selection) highlight the need for more detailed, taxa‐specific mechanistic models. Even coarse considerations of metabolism will likely lead to improved predictions over exclusively considering thermal tolerance for endotherms.
The metabolic hormone adiponectin affects the correlation between nutritional status and pneumococcal vaccine response in vulnerable indigenous children
<p class="MsoNoSpacing"><strong><span>Background:</span></strong><span> Almost 200 million children worldwide are either undernourished or overweight</span><span>. </span><span>Only a few studies have addressed the effect of variation in nutritional status on vaccine response</span><span>. </span><span>We previously demonstrated an association between stunting and an increased post-vaccination 13-valent pneumococcal conjugate vaccine (PCV13) response. In this prospective study, we assessed to what extent metabolic hormones may be a modifier in the association between nutritional status and PCV13 response.</span></p> <p class="MsoNoSpacing"><strong><span>Methods: </span></strong><span>Venezuelan children aged 6 weeks to 59 months were vaccinated with a primary series of PCV13. Nutritional status and serum levels of leptin, adiponectin and ghrelin were measured upon vaccination and their combined effect on serum post-vaccination antibody concentrations was assessed by generalized estimating equations multivariable regression analysis.</span></p> <p class="MsoNoSpacing"><strong><span>Results:</span></strong><span> A total of 210 children were included, of whom 80 were stunted, 81 had a normal weight and 49 were overweight. Overweight children had lower post-vaccination antibody concentrations than normal weight children </span><span>(regression coefficient -1.15, 95% CI -2.22 – -0.072)</span><span>. Additionally, there was a significant adiponectin-nutritional status interaction. In stunted children, higher adiponectin serum concentrations were associated with lower post-PCV13 antibody concentrations </span><span>(regression coefficient -0.19, 95% CI -0.24 – -0.14) </span><span>while the opposite was seen in overweight children </span><span>(regression coefficient 0.14, 95% CI 0.049 – 0.22)</span><span>. </span></p> <p><strong><span>Conclusion:</span></strong><span> Metabolic hormones, in particular adiponectin, may modify the effect of nutritional status on pneumococcal vaccine response. These findings emphasize the importance of further research to better understand the immunometabolic pathways underlying vaccine response and enable a future of optimal personalized vaccination schedules.</span></p>
Decoding the metabolic response of Escherichia coli for sensing trace heavy metals in water
<p>As: Raman spectra from E. coli lysate sample after exposing to As in DI water</p> <p>Cr: Raman spectra from E. coli lysate sample after exposing to Cr in DI water</p> <p>As_TapWater: Raman spectra from E. coli lysate sample after exposing to As in tap water</p> <p>WasteWater_FineTune_Dataset: Raman spectra from E. coli lysate sample after exposing to As in waste water</p> <p>WasteWater 'Unknow' Dataset: Raman spectra from E. coli lysate sample after exposing to waste water</p>
Plant secondary metabolic responses to global climate change: A meta-analysis in medicinal and aromatic plants
<p><span>Plant secondary metabolites (SMs) play crucial roles in plant-environment interactions and contribute greatly to human health. Global climate changes are expected to dramatically affect plant secondary metabolism, yet a systematic understanding of such influences is still lacking. Here, we employed medicinal and aromatic plants (MAAPs) as model plant taxa and performed a meta-analysis from 360 publications using 1828 paired observations to assess the responses of different SMs levels and the accompanying plant traits to elevated carbon dioxide (eCO<sub>2</sub>), elevated temperature (eT), elevated nitrogen deposition (eN), and decreased precipitation (dP). The overall results showed that phenolic and terpenoid levels generally respond positively to eCO<sub>2</sub> but negatively to eN, while the total alkaloid concentration was increased remarkably by eN. By contrast, dP promotes the levels of all SMs, while eT exclusively exerts a positive influence on the levels of phenolic compounds. Further analysis highlighted the dependence of SM responses on different moderators such as plant functional types, climate change levels or exposure durations, mean annual temperature and mean annual precipitation. Moreover, plant phenolic and terpenoid responses to climate changes could be attributed to the variations in C/N ratio and total soluble sugar levels, while the <em>trade-off</em> supposition contributed to SM responses to climate changes other than eCO<sub>2</sub>. Taken together, our results predicted the distinctive SM responses to diverse climate changes in MAAPs, and allowed us to define potential moderators responsible for these variations. Further, linking SM responses to C-N metabolism and growth-defence balance provided biological understandings in terms of plant secondary metabolic regulation.</span></p>
miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses
<p>NGS extracelular vesicles miRNA total reads of three pooled plasma samples from sedentary(C), endurance (E) and resitance (R) 4-week trained mice.</p>
Data set for manuscript titled "Morphological, physiological and metabolic responses of diverse barley inbreds to dry down and moderate drought stress"
<p>The primary aim of the study was to understand the genotypic diversity on plant morphology, photosynthetic responses, metabolite shift and their relationship in diverse barley inbreds under dry down (DD) and moderate drought (MD) stress using 23 genetically diverse parental inbreds. The data were collected from over a period of 28 days after the start of stress treatment. The publised data set indcludes the emmeans of all the evaluated characters. Metabolite profiling was done in samples collected from 7 d and 12 d after the start of DD and MD stress.</p>
Metabolic response of yellow mealworm larvae to two alternative rearing substrates
<p>The quantitative one-dimensional <sup>1</sup>H NMR representative spectra of lipid and polar metabolites fractions of Tenebrio molitor larvae fed two alternative dietary substrates described in the manuscript draft entiteld:</p> <p><strong>Metabolic response of yellow mealworm larvae to two alternative rearing substrates</strong></p>
Data for Marshall et al, "Microbial metabolism disrupts cytokine activity to impact host immune response"
<p>Raw data for publication "Microbial metabolism disrupts cytokine activity to impact host immune response", Marshall EKP et al. The archive is organized into folders containing raw data pertaining to each figure.</p>
Dataset on biomarkers for the project "Intermittent hypoxia differentially affects metabolic and oxidative stress responses in two species of cyprinid fish"
<p>The file contains the data for the tissue-level biomarkers evaluating the impact of short-term hypoxia on oxidative stress and metabolic parameters in silver carp <em>Hypophthalmichthys molitrix </em>and gibel carp <em>Carassius gibelio.</em></p>
Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease
ClinicalTrials.gov study NCT04299308. IPD Sharing: NO. Countries: 1. Publications: 2.
Food Intake Response to Short-Term Modifications of Metabolism in Humans
ClinicalTrials.gov study NCT02939404. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
The metabolic hormone adiponectin affects the correlation between nutritional status and pneumococcal vaccine response in vulnerable indigenous children
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Plant secondary metabolic responses to global climate change: A meta-analysis in medicinal and aromatic plants
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Data from: Metabolic and immunological responses of Drosophila melanogaster to dietary restriction and bacterial infection differ substantially between genotypes in a population
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The same species, not the same invader: Metabolic responses of genetically distinct invasive populations of Dikerogammarus villosus and their intraspecific hybrid to environmental stresses
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Data from: Does metabolism constrain bird and mammal ranges and predict shifts in response to climate change?
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Coping with feast and famine: Integrated behavioral and metabolically flexible responses of wild orangutans to ecologically driven dietary variation
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Data from: Quantifying liver-toxic responses from dose-dependent chemical exposures using a rat genome-scale metabolic model
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Multi-omics analysis reveals the glycolipid metabolism response mechanism in the liver of Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus) under hypoxia stress
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OpenNeuro
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