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29
datasets available to search
ShareScore release 0.9.0
Dataset results
29 results for “Microbial Pathogens”
Glucose competition between immune cells and microbial pathogens controls infections
GEO Series GSE99904. Candida albicans; Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Data from: The impact of bottlenecks on microbial survival, adaptation and phenotypic switching in host-pathogen interactions
Microbial pathogens and viruses can often maintain sufficient population diversity to evade a wide range of host immune responses. However, when populations experience bottlenecks, as occurs frequently during initiation of new infections, pathogens require specialized mechanisms to regenerate diversity. We address the evolution of such mechanisms, known as stochastic phenotype switches, which are prevalent in pathogenic bacteria. We analyze a model of pathogen diversification in a changing host environment that accounts for selective bottlenecks, wherein different phenotypes have distinct transmission probabilities between hosts. We show that under stringent bottlenecks, such that only one phenotype can initiate new infections, there exists a threshold stochastic switching rate below which all pathogen lineages go extinct, and above which survival is a near certainty. We determine how quickly stochastic switching rates can evolve by computing a fitness landscape for the evolutionary dynamics of switching rates, and analyzing its dependence on both the stringency of bottlenecks and the duration of within-host growth periods. We show that increasing the stringency of bottlenecks or decreasing the period of growth results in faster adaptation of switching rates. Our model provides strong theoretical evidence that bottlenecks play a critical role in accelerating the evolutionary dynamics of pathogens.
IMPACT STUDY: Investigating Microbial Pathogen Activity of Copper Textiles
ClinicalTrials.gov study NCT02627092. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: The impact of bottlenecks on microbial survival, adaptation and phenotypic switching in host-pathogen interactions
Open the record for dataset details and reuse information.
Gingival Epithelial Cell Transcriptional Responses to Pathogenic Oral Microbial Species.
GEO Series GSE9723. Homo sapiens. 12 samples. Type: Expression profiling by array.
FIGURE 1 in The RNA-seq approach to discriminate gene expression profiles in response to Beauveria bassiana and Micrococcus luteus microbial pathogens on Actias selene (Lepidoptera: Saturniidae)
FIGURE 1. The Venn diagram shows DEGs after different bacterial stimulation to Actias selene. PBS-samples pretreated with PBS; Bb-samples pretreated with B. bassiana; ML-samples pretreated with M. luteus.
The dynamic landscape of coding and non-coding RNAs in the innate immune response to microbial pathogens
GEO Series GSE109084. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
International Space Station - Microbial Observatory of Pathogenic Virus, Bacteria, and Fungi project
This study investigated the interplay between the microbial community of the International Space Station and its crew. Environmental samples were collected from 8 habitable locations around the ISS. The microbial composition was measured using shotgun metagenomic sequencing and procesed using the Livermore Metagenomics Analysis Toolkit.
STAT3 regulates pathogen control and clearance in macrophages by reprogramming inflammation-induced microbial defense response
GEO Series GSE282695. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.