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114 results for “Multimodal data”
Data for "A multimodal machine learning fused global 0.1° daily evapotranspiration dataset from 1950-2022" (1950-1974)
<p>The data contains simulation results from 1950-1974, 25 years total.</p> <p>You can access the remaining part of the dataset via Qingchen Xu and Lu Li (2025) using the following reference:<br>Qingchen Xu, & Lu Li. (2025). Data for "A multimodal machine learning fused global 0.1° daily evapotranspiration dataset from 1950-2022" (1975-1999) [Data set]. Zenodo. https://doi.org/10.5281/zenodo.15671253</p> <p>Qingchen Xu, & Lu Li. (2025). Data for "A multimodal machine learning fused global 0.1° daily evapotranspiration dataset from 1950-2022" (2000-2024) [Data set]. Zenodo. https://doi.org/10.5281/zenodo.15671254</p>
Data from: Brittle sedimentary strata focus a multimodal depth distribution of seismicity during hydraulic fracturing in the Sichuan basin, southwest China
<p>The number of background earthquakes (<em>M<sub>L</sub></em> ≥ 0) in the southern Sichuan basin, southwest China, has increased thirtyfold as a result of hydraulic fracturing. Background events are originally deep (4-6 <em>km</em>) within the sedimentary section but build into a multimodal distribution both at depth and in the shallow stimulated reservoir (2-4 <em>km</em>) - representing a counterpoint to the usual triggering of seismicity on deep sub-reservoir basement faults. Surprisingly, the largest events (<em>M<sub>L</sub></em> ≥ 3) evolve in the deep sedimentary strata (4-6 <em>km</em>) that are hydraulically isolated from the injection zone (2-4 <em>km</em>) by low permeability layers. We evaluate the friction-stability rheology of the strata within the full stratigraphic section to define the feasibility of nucleation within these shallow and deep strata. These show velocity-neutral to velocity-weakening behavior in the shallow reservoir transitioning to more strongly velocity-weakening with increase in both depth and temperature. Poroelastic stress calculations confirms that stress transfer, rather than transmitted fluid pressures, are capable of directly reactivating critically-stressed faults at depth, with fluid pressures the triggering source within the shallow reservoir.</p>
msiFlow: Automated Workflows for Reproducible and Scalable Multimodal Mass Spectrometry Imaging and Immunofluorescence Microscopy Data Processing and Analysis
<p>This record contains example and result data of msiFlow.</p> <p>msiFlow is a collection of automated workflows for reproducible and scalable multimodal mass spectrometry imaging (MSI) and immunofluorescence microscopy (IFM) data processing and analysis. Using an experimental mouse model for urinary tract infection, induced by uropathogenic E.coli (UPEC), we generated data by</p> <ul> <li>matrix-assisted laser desorption ionisation mass spectrometry imaging with laser-induced postionisation (MALDI-2 MSI) using the Bruker timsTOFfleX instrument</li> <li>transmission-mode MALDI-2 MSI (t-MALDI-2)</li> <li>immunofluorescence microscopy (IFM) using the MACSima system from Miltenyi </li> </ul> <p>msiFlow was tested on MALDI-2 MSI, t-MALDI-2 MSI and IFM data of control and UPEC-infected mouse bladder sections. In IFM we used Ly6G and actin for staining neutrophils and the muscle layer. We validated msiFlow on MALDI MSI data of bone marrow (BM)-derived neutrophils. Tentative lipid annotations were validated by MALDI DDA MSI and MALDI MS/MS. All data used and results generated by msiFlow are included in this dataset (besides the intermediate results of the MALDI-2 preprocessing due to data size).</p> <p>The dataset contains the following zip files:</p> <table> <tbody> <tr> <td><strong>zip file</strong></td> <td><strong>description</strong></td> </tr> <tr> <td>ly6g_heterogeneity.zip</td> <td>example and result data (Ly6G clusters) for molecular_heterogeneity_flow</td> </tr> <tr> <td>if_segmentation.zip</td> <td>example and result data (Ly6G segmentation) for if_segmentation_flow</td> </tr> <tr> <td>ly6g_heterogeneity_signatures.zip</td> <td>example and result data (lipids for Ly6G clusters) for molecular_signatures_flow</td> </tr> <tr> <td>ly6g_molecular_signatures.zip</td> <td>example and result data (lipids for Ly6G) for molecular_signatures_flow</td> </tr> <tr> <td>msi_if_registration.zip</td> <td>example and result data for msi_if_registration_flow</td> </tr> <tr> <td>msi_segmentation.zip</td> <td>example and result data (segmented MSI bladder data) for msi_segmentation_flow</td> </tr> <tr> <td>region_group_analysis.zip</td> <td>example and result data (regulated lipids in different bladder tissue regions) for region_group_analysis_flow</td> </tr> <tr> <td>macsima.zip</td> <td>raw IFM data of UPEC-infected bladders containing Ly6G, actin and autofluorescence images</td> </tr> <tr> <td>maldi-bm-neutrophils.zip</td> <td>raw and pre-processed MALDI MSI data of BM-derived neutrophils</td> </tr> <tr> <td>t-maldi-2.zip</td> <td>raw t-MALDI-2 MSI data of a UPEC-infected bladder section</td> </tr> <tr> <td>maldi-2-<em>group-sampleno</em>.zip</td> <td>raw MALDI-2 MSI data of a control/UPEC bladder section</td> </tr> <tr> <td>MALDI_DDA_MSI.zip</td> <td>raw MALDI MSI data acquired in DDA mode</td> </tr> <tr> <td>TIMS_MS_MS.zip</td> <td>raw MALDI TIMS MS/MS data</td> </tr> </tbody> </table> <p> </p>
Supporting data for "Telecom-heralded entanglement between multimode solid-state quantum memories"
<p>This repository contains the data supporting the article "Telecom-heralded entanglement between multimode solid-state quantum memories" by Dario Lago-Rivera, Samuele Grandi, Jelena V. Rakonjac, Alessandro Seri and H. de Riedmatten, Nature 2021.</p> <p>The individual .zip files contain the raw detection files for all the storage times and losses reported in the article, for the measurement of diagonal and off-diagonal elements of the density matrix.</p>
Multimodal Electric Guitar Data
<p>A dataset of thirty-six student and semiprofessional electric guitarists performing a set of basic sound-producing actions as well as free improvisations. The multimodal dataset consists of EMG and motion capture data; additionally, video and sound recordings of each performer were made.</p>
Multimodal dataset: Protein Function Prediction using STRING data & COVID19 Mortality Model by EI
<p>The PFP.zip file contains 1. 5 well-formated GO terms dataset for EI, 2. STRING data 3. GO term annotation. The last two could be merged by the 'generate_data.py' script in https://github.com/GauravPandeyLab/ensemble_integration</p> <p>The covid19_model_built.zip contained the EI model built based on the COVID-19 Mortality dataset, the detail of usage are here:.</p>
PiH Dataset for Determining Exception Context in Assembly Operations form Multimodal Data
<p>PiH Dataset used in Simonič, M.; Majcen Hrovat, M.; Džeroski, S.; Ude, A.; Nemec, B. Determining Exception Context in Assembly Operations from Multimodal Data. <em>Sensors</em> <strong>2022</strong>, <em>22</em>, 7962. https://doi.org/10.3390/s22207962</p> <p>The dataset consists of color images of different outcomes of the PiH task as well as the corresponding Cartesian pose of the robot end-effector and force torque data. Data is organized into two folders, representing one of the two possible insertion slots. In each of the folders, data is further split into the following cases:<br> - error in insertion target position ranging from -10 to 10 mm in x direction in 1 mm steps,<br> - error in insertion target position ranging from -10 to 10 mm in y direction in 1 mm steps,<br> - no positional error.</p> <p>Multiple attempts were made for each case.</p> <p>Each entry has unique date-time tag and comprises: RGB image (.jpg) and .mat file with <em>states </em>object that contains reference and measured target pose in Cartesian space (positions and quaternions) and raw force-torque sensor data and force-torque data transformed to the tool frame.</p> <p>The experiments were performed with Franka Emika Panda collaborative robot. For acquisition of image data an Intel Realsense D435 RGB-D camera has been utilized. </p>
Rings Insertion Dataset for Determining Exception Context in Assembly Operations form Multimodal Data
<p>Rings Insertion Dataset used in Simonič, M.; Majcen Hrovat, M.; Džeroski, S.; Ude, A.; Nemec, B. Determining Exception Context in Assembly Operations from Multimodal Data. <em>Sensors</em> <strong>2022</strong>, <em>22</em>, 7962. https://doi.org/10.3390/s22207962</p> <p>The dataset consists of color images of different outcomes of the ring insertion task as well as the corresponding Cartesian pose of the robot end-effector and force torque data. Data is organized into four folders, representing one of the possible insertion slots. In each of the folders, data is further split into the following cases:<br> - error in insertion target position ranging from -3 to 3 mm in x direction in 1 mm steps,<br> - error in insertion target position ranging from -3 to 3 mm in y direction in 1 mm steps,<br> - no positional error,<br> - other unidentified error (bad insertion).</p> <p>Multiple attempts were made for each case.</p> <p>Each entry has unique date-time tag and comprises: RGB image (.jpg) and .mat file with <em>states </em>object that contains reference and measured target pose in Cartesian space (positions and quaternions) and raw force-torque sensor data and force-torque data transformed to the tool frame.</p> <p>The experiments were performed with Franka Emika Panda collaborative robot. For acquisition of image data an Intel Realsense D435 RGB-D camera has been utilized. </p>
Multimodal data set for the investigation of the early stage of plasticity in a polycrystalline titanium sample
<p>This dataset is the result of several experiments to study the early stage of plasticity in a polycrystalline sample of a commercially pure alpha phase grade 2 titanium (CP-Ti family). The study aimed to achieve three critical goals: first, the acquisition of a 3D representation of the microstructure; second, the conduction of in situ measurements capturing grain-scale plasticity dynamics during a controlled tensile test; and third, a rigorous comparison of these experimental observations against the predictions derived from a microstructure-sensitive crystal plasticity simulation. This simulation was conducted on a digital twin of the titanium sample, aiming to assess the predictive accuracy of the model at the local scale. The data set was assembled from the different sources using the Pymicro package. </p>
Data for: Multimodal convergence in the pedunculopontine tegmental nucleus: motor, sensory, and theta-frequency inputs influence the activity of single neurons
<p>The pedunculopontine tegmental nucleus of the brainstem (PPTg) has extensive interconnections and neuronal-behavioural correlates. It is implicated in movement control and sensorimotor integration. We investigated whether single neuron activity in freely moving rats is correlated with components of skilled forelimb movement and whether individual neurons respond to both motor and sensory events. We found that individual PPTg neurons showed changes in firing rate at different times during the reach. This type of temporally specific modulation is like activity seen elsewhere in voluntary movement control circuits, such as the motor cortex, and suggests that PPTg neural activity is related to different specific events occurring during the reach. In particular, many neuronal modulations were time-locked to the end of the extension phase of the reach, when fine distal movements related to food grasping occur, indicating strong engagement of PPTg in this phase of skilled individual forelimb movements. In addition, some neurons showed brief periods of apparent oscillatory firing in the theta range at specific phases of the reach-to-grasp movement. When movement-related neurons were tested with tone stimuli, many also responded to this auditory input, allowing for sensorimotor integration at the cellular level. Together, these data extend the concept of the PPTg as an integrative structure in the generation of complex movements, by showing that this function extends to the highly coordinated control of the forelimb during skilled reach to grasp movement and that sensory and motor-related information converges on a single neuron, allowing for direct integration at the cellular level.</p>
Source data for publication "A multimodal atlas of hepatocellular carcinoma reveals convergent evolutionary paths and 'bad apple' effect on clinical trajectory" in Journal of Hepatology
<p>Processed genomic and transcriptomic data for the publication <a href="https://doi.org/10.1016/j.jhep.2024.05.017">https://doi.org/10.1016/j.jhep.2024.05.017</a>.</p> <p>cnv_segmentation.tsv: CNV segmentation file from Sequenza.</p> <p>cnv_arm.tsv: Significant arm level CNV events called by GISTIC, from broad_values_by_arm.txt file.</p> <p>cnv_gene.tsv: Gene level CNV events called by GISTIC, from all_threshold_by_genes.txt file. </p> <p>RNA_raw_counts.tsv: Raw RNA-seq read counts from featureCounts.</p> <p>snv_indel.tsv: All SNV and Indel called with annotation from Funcotator.</p> <p> </p>
Data from: Changes in brain structure and function following exposure to oral LSD during adolescence: A multimodal MRI study
<p><em>Background</em>: LSD is a hallucinogen with complex neurobiological and behavioral effects. Underlying these effects are changes in brain neuroplasticity. This is the first study to follow the developmental changes in brain structure and function following LSD exposure in periadolescence. We hypothesized LSD given during a time of heightened neuroplasticity, particularly in the forebrain, would affect cognitive and emotional behavior and the associated underlying neuroanatomy and neurocircuitry. </p> <p><em>Methods:</em> Female and male mice were given vehicle, single, or multiple treatments of 3.3 µg of LSD by oral gavage starting on postnatal day 51. Between postnatal days 90-120 mice were imaged and tested for cognitive and motor behavior. MRI data from voxel-based morphometry, diffusion weighted imaging, and BOLD resting state functional connectivity were registered to a mouse 3D MRI atlas with 139 brain regions providing site-specific differences in global brain structure and functional connectivity between experimental groups.</p> <p><em>Results:</em> Motor behavior and cognitive performance were unaffected by periadolescent exposure to LSD. Differences across experimental groups in brain volume for any of the 139 brain areas were few in number and not focused on any specific brain region. Multiple exposures to LSD significantly altered gray matter microarchitecture across much of the brain. These changes were primary associated with the thalamus, sensory and motor cortices, and basal ganglia. The forebrain olfactory system and prefrontal cortex and hindbrain cerebellum and brainstem were unaffected. The functional connectivity between forebrain white matter tracts and sensorimotor cortices and hippocampus was reduced with multidose LSD exposure.</p> <p><em>Conclusion:</em> Does early exposure to LSD in periadolescence have lasting effects on brain development? There was no evidence of LSD having consequential effects on cognitive or motor behavior when animal were evaluated as young adults 90-120 days of age. Neither were there any differences in the volume of specific brain areas between experimental conditions. The pronounced changes in indices of anisotropy across much of the brain would suggest altered gray matter microarchitecture and neuroplasticity. The reduction in connectivity in forebrain white matter tracts with multidose LSD and consolidation around sensorimotor and hippocampal brain areas requires a battery of tests to understand the consequences of these changes on behavior.</p>
A multimodal data-set of a unidirectional glass fibre reinforced polymer composite
<p>Please cite the following article when using the data-sets hereby shared:</p> <p>Emerson, M.J., Dahl, V.A., Conradsen, K., Mikkelsen, L.P. and Dahl, A.B., 2018. A multimodal data-set of a unidirectional glass fibre reinforced polymer composite. <em>Data in brief</em>, <em>18</em>, pp.1388-1393.</p> <p>These data-sets were used for validating the use of X-ray tomography and our dictionary-based probabilistic method for detection of individual fibres, for more information see the following article:</p> <p>Emerson, M.J., Dahl, V.A., Conradsen, K., Mikkelsen, L.P. and Dahl, A.B., 2018. Statistical validation of individual fibre segmentation from tomograms and microscopy. <em>Composites Science and Technology</em>, <em>160</em>, pp.208-215.</p>
Data from: Functionally redundant multimodal predator cues elicit changes in prey foraging behavior
<p><span>Many prey species can assess the risk of predation from information acquired through different sensory systems. For many animals, this information is detected with sensory organs specialized for visual (sight) or chemical (smell or taste) stimuli. It is unclear, however, whether information acquired through multiple sensory systems is functionally redundant or interchangeable, especially if the message is the same. Here we assess prey response to unimodal visual and chemical cues as well as multimodal (visual + chemical) cues. We specifically test if a foraging individual shows a stronger behavioral response to risk when they can perceive that risk through multimodal versus unimodal cues. To do this, we measured the functional response (prey abundance-foraging rate relationship) of Tibellus oblongus spiders foraging on midges while exposing them to visual stimuli, chemical stimuli, or a combination of both visual and chemical stimuli from potential predators. We then determined if the spider's functional response for the multimodal treatment differed more strongly from a control treatment than from either unimodal treatment. We found that under any simulated predation risk (multimodal and both unimodal), T. oblongus spiders showed longer handling times than in control groups without risk. </span><span>However, we saw no elevated anti-predator response in the multimodal treatment, suggesting that information from visual and chemical modalities is interchangeable and sufficient to indicate reliably predation risk. </span></p>
Data for: Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila
<p>Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulus-relevant behaviors, and the ability of multimodal nociceptor neurons to discriminate between potentially harmful and innocuous stimuli is broadly important for organismal survival. Moreover, disruptions in the capacity to differentiate between noxious and innocuous stimuli can result in neuropathic pain. <em>Drosophila</em> larval Class III (CIII) neurons are peripheral noxious cold nociceptors and innocuous touch mechanosensors; high levels of activation drive cold-evoked contraction (CT) behavior, while low levels of activation result in a suite of touch-associated behaviors. However, it is unknown what molecular factors underlie CIII multimodality. Here, we show that the TMEM16/anoctamins <em>subdued</em> and <em>white walker</em> (<em>wwk</em>; <em>CG15270</em>) are required for cold-evoked CT, but not for touch-associated behavior, indicating a conserved role for anoctamins in nociception. We also evidence that CIII neurons make use of atypical depolarizing chloride currents to encode cold, and that overexpression of <em>ncc69</em>-a fly homologue of <em>NKCC1</em>-results in phenotypes consistent with neuropathic sensitization, including behavioral sensitization and neuronal hyperexcitability, making <em>Drosophila</em> CIII neurons a candidate system for future studies of the basic mechanisms underlying neuropathic pain</p>
HiCube: Interactive visualization of multiscale and multimodal Hi-C and 3D genome data
<p>Test dataset for HiCube.</p> <p>HiCube is a lightweight web application for interactive visualization and exploration of diverse types of genomics data at multiscale resolutions. Especially, HiCube displays synchronized views of Hi-C contact maps and three-dimensional (3D) genome structures with user-friendly annotation and configuration tools, thereby facilitating the study of 3D genome organization and function.</p> <p>HiCube is implemented in Javascript and can be installed via NPM. The source code is freely available at GitHub (https://github.com/wmalab/HiCube).</p>
The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
<h1>The SIGMA templates and atlases for the Wistar Rat Brain</h1> <p>The current document is a short description of the second version of the SIGMA resources for the Wistar rat brain. For a full description of the resources and the methodologies used to create them please consult the main publication [Barriere D.A. et al 2019].</p> <p>The SIGMA resources are a set of standardized MRI compatible templates and atlases meant to support the analysis of multimodal MRI data of the rat brain. They were developped as part of the SIGMA project, a collaborative project between French (CEA and INSERM) and Portuguese (ICVS) institutions (FCT-ANR/NEU-OSD/0258/2012). They provide a unified and standardized framework for the analysis of multimodal rat brain imaging data, allowing the reporting of results within the coordinate system of the Paxinos-Watson atlas.</p> <p>In this second version, standardized MRI compatible templates have been built from the original acquired data (11.7 Tesla Bruker Scanner at Neuropsin center <a href="https://www.cea.fr/drf/joliot/en/Pages/research_entities/NeuroSpin.aspx" rel="nofollow">https://www.cea.fr/drf/joliot/en/Pages/research_entities/NeuroSpin.aspx</a>) and emulated using the methods developed by Gabriel A. Devenyi (<a href="https://github.com/gdevenyi">https://github.com/gdevenyi</a>) and available here : <a href="https://github.com/CoBrALab/optimized_antsMultivariateTemplateConstruction">https://github.com/CoBrALab/optimized_antsMultivariateTemplateConstruction</a>. This pipeline is a re-implementation of the ANTs template construction pipeline requiring ANTs for the primary commands, and running on our cluster facilities using qbatch (<a href="https://islande.hub.inrae.fr/infrastructure" rel="nofollow">https://islande.hub.inrae.fr/infrastructure</a>).</p> <p>Using this methodology we firstly, updated the previous SIGMA spaces (T2sw, T2w, T1w) previously generated using the DARTEL Methods implemented in SPM8 and normalized the whole head images instead of brain.</p> <p>Secondly, we updated the probabilistic maps of the rat brain which are mandatory for the automatic segmentation of the rat brain and standardisation of morphometric analysis. Namely, we created new maps of Grey Matter, White Matter, CSF, Skull and outbrain. Those maps allow the use of SIGMA with the latter release of SPM12, a popular neuroimaging software dedicated to brain imaging analysis but also with ANTs, FSL and AFNI. Additionnally, we revised the Grey Matter/White Matter segmentations since the limits of which (particularly at the thalamic level) were a matter to debate with some users in the previous version of SIGMA.</p> <p>Thirdly, additionnal templates have been created using the optimized ANTs methodology to create from original unpublished data diffusion templates (B0, FA, etc.) at both ex-vivo and in-vivo resolutions.</p> <p>Eventually, using the same strategy, we created a CT/18FDG reference space from data obtained previously [Barrière D.A. et al 2018] which has been normalized with the MRI ex-vivo SIGMA template allowing to the SIGMA resource to propose a multimodal space for CT/TEP/MRI normalisation.</p> <h2><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#organisation-of-the-sigma-resources"></a></h2> <h2>Organisation of the SIGMA resources</h2> <p>The SIGMA resources have been organized as four sections : anatomical Imaging, functional imaging, atlases and TEP/CT imaging</p> <h3><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#anatomical-imaging"></a></h3> <h3>Anatomical Imaging</h3> <p>In this section a set of templates, priors and brain masks is available for ex-vivo and in-vivo data normalization</p> <h4><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#ex-vivo-t2-weighted"></a></h4> <h4>Ex-vivo T2*-weighted</h4> <p>T2*-weighted template + T2*-weighted map + associated probabilistics maps (GM, WM, CSF, Skull, outbrain) + brain mask.</p> <p>Spatial resolution 0.09x0.09x0.09mm.</p> <div> <pre><code> SIGMA_ExVivo_Anatomical_Brain_csf.nii.gz SIGMA_ExVivo_Anatomical_Brain_gm.nii.gz SIGMA_ExVivo_Anatomical_Brain_mask.nii.gz SIGMA_ExVivo_Anatomical_Brain_out.nii.gz SIGMA_ExVivo_Anatomical_Brain_skull.nii.gz SIGMA_ExVivo_Anatomical_Brain_t2starmap.nii.gz SIGMA_ExVivo_Anatomical_Brain_template.nii.gz SIGMA_ExVivo_Anatomical_Brain_wm.nii.gz </code></pre> <div> </div> </div> <h4><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#ex-vivo-diffusion"></a></h4> <h4>Ex-vivo diffusion</h4> <p>B0 template + FA template + associated probabilistics maps (GM, WM, CSF, Skull, outbrain) + brain mask.</p> <p>Spatial resolution 0.25x0.25x0.25mm.</p> <div> <pre><code> SIGMA_ExVivo_Diffusion_Brain_b0.nii.gz SIGMA_ExVivo_Diffusion_Brain_csf.nii.gz SIGMA_ExVivo_Diffusion_Brain_fa.nii.gz SIGMA_ExVivo_Diffusion_Brain_gm.nii.gz SIGMA_ExVivo_Diffusion_Brain_mask.nii.gz SIGMA_ExVivo_Diffusion_Brain_out.nii.gz SIGMA_ExVivo_Diffusion_Brain_skull.nii.gz SIGMA_ExVivo_Diffusion_Brain_wm.nii.gz </code></pre> <div> </div> </div> <h4><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#in-vivo-t2-weighted"></a></h4> <h4>In-vivo T2-weighted</h4> <p>T2-weighted template + associated probabilistics maps (GM, WM, CSF, Skull, outbrain) + brain mask.</p> <p>Spatial resolution 0.15x0.15x0.15mm.</p> <div> <pre><code> SIGMA_InVivo_Anatomical_Brain_csf.nii.gz SIGMA_InVivo_Anatomical_Brain_gm.nii.gz SIGMA_InVivo_Anatomical_Brain_mask.nii.gz SIGMA_InVivo_Anatomical_Brain_out.nii.gz SIGMA_InVivo_Anatomical_Brain_skull.nii.gz SIGMA_InVivo_Anatomical_Brain_template.nii.gz SIGMA_InVivo_Anatomical_Brain_wm.nii.gz </code></pre> <div> </div> </div> <h4><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#in-vivo-diffusion"></a></h4> <h4>In-vivo diffusion</h4> <p>T2-weighted template + B0 template + FA template + ADC template + brain mask.</p> <p>Spatial resolution 0.375x0.375x0.375mm.</p> <div> <pre><code> SIGMA_InVivo_Diffusion_Brain_adc.nii.gz SIGMA_InVivo_Diffusion_Brain_b0.nii.gz SIGMA_InVivo_Diffusion_Brain_fa.nii.gz SIGMA_InVivo_Diffusion_Brain_mask.nii.gz SIGMA_InVivo_Diffusion_Brain_t2.nii.gz </code></pre> <div> </div> </div> <h3><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#functional-imaging"></a></h3> <h3>Functional Imaging</h3> <p>T2-weighted template + associated probabilistics maps (GM, WM, CSF, Skull, outbrain) + brain mask.</p> <p>Spatial resolution 0.375x1x0.375mm.</p> <div> <pre><code> SIGMA_InVivo_Functional_Brain_csf.nii.gz SIGMA_InVivo_Functional_Brain_epi.nii.gz SIGMA_InVivo_Functional_Brain_gm.nii.gz SIGMA_InVivo_Functional_Brain_mask.nii.gz SIGMA_InVivo_Functional_Brain_t2.nii.gz SIGMA_InVivo_Functional_Brain_wm.nii.gz </code></pre> <div> </div> </div> <h3><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#sigma-rat-brain-atlas-version-20--waxholm-atlas-feat-sigma"></a></h3> <h3>SIGMA Rat Brain Atlas Version 2.0 : Waxholm atlas Feat. SIGMA</h3> <p>In this second version of the SIGMA resources we deliver a new SIGMA brain atlas obtained by the normalization of the Waxholm space published by Kleven, H. et al. Nat Methods (2023, <a href="https://doi.org/10.1038/s41592-023-02034-3" rel="nofollow">https://doi.org/10.1038/s41592-023-02034-3</a><a title="La ressource a été trouvée dans UNPAYWALL" href="https://www.nature.com/articles/s41592-023-02034-3.pdf" target="_blank" rel="noopener"></a>). The Waxholm rat brain atlas is currently the best numerical 3D atlas of the rat brain. In accordance with authors of this paper we are authorized to modify and embed the WHS atlas within the SIGMA environement to standardize the identification of brain territories. We provide a normalized version the WHS for both ex-vivo and in-vivo of the anatomical SIGMA templates. Finally, we offer linear and non-linear transformations to enable your data to commute between the SIGMA and WHS ex-vivo environments using ANTs commands.</p> <h4><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#ex-vivo-atlas"></a></h4> <h4>Ex-vivo atlas</h4> <p>WHS rat brain atlas normalized in ex-vivo T2*-weighted SIGMA template + List of 222 labels created in ITKSnap Format + linear and non-linear transformations for SIGMA-WHS journeys (WHS-to-SIGMA_Transformations folder).</p> <p>Spatial resolution 0.09x0.09x0.09mm.</p> <div> <pre><code> SIGMA_ExVivo_Anatomical_Brain_Atlas.nii.gz SIGMA_ExVivo_Anatomical_Brain_Atlas.txt ./WHS-to-SIGMA_Transformations/reference_SIGMA.nii.gz ./WHS-to-SIGMA_Transformations/reference_WHS.nii.gz ./WHS-to-SIGMA_Transformations/WHS-in-SIGMA_transform_01_InverseWarp.nii.gz ./WHS-to-SIGMA_Transformations/WHS-in-SIGMA_transform_01_Warp.nii.gz ./WHS-to-SIGMA_Transformations/WHS-in-SIGMA_transform_02_GenericAffine.mat ./WHS-to-SIGMA_Transformations/WHS-in-SIGMA_transform_03_GenericAffine.mat ./WHS-to-SIGMA_Transformations/WHS_SD_rat_atlas_v4.nii.gz ./WHS-to-SIGMA_Transformations/WHS-to-SIGMA_byANTS.txt </code></pre> <div> </div> </div> <h4><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#in-vivo-atlas"></a></h4> <h4>In-vivo atlas</h4> <p>WHS rat brain atlas normalized in in-vivo T2 SIGMA anatomical template + List of 222 labels created in ITKSnap Format.</p> <p>Spatial resolution 0.15x0.15x0.15mm.</p> <div> <pre><code> SIGMA_InVivo_Anatomical_Brain_Atlas.nii.gz SIGMA_InVivo_Anatomical_Brain_Atlas.txt </code></pre> <div> </div> </div> <h4><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#sigma-brain-meshes"></a></h4> <h4>SIGMA brain meshes</h4> <p>Rat brain mesh created using BrainNet viewers commands in matlab (<a href="https://www.nitrc.org/projects/bnv/" rel="nofollow">https://www.nitrc.org/projects/bnv/</a>).</p> <p>Spatial resolution 0.09x0.09x0.09mm.</p> <div> <pre><code> SIGMA_Anatomical_Brain_Atlas_mesh.nv </code></pre> <div> </div> </div> <h4><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#sigma-functional-atlas"></a></h4> <h4>SIGMA functional atlas</h4> <p>In the original publication of the SIGMA resources, we developed a functional atlas for the rat brain, using a group ICA analysis validated through a RAICAR approach. From this analysis, we identified 59 bilateral ROIs covering cortical, sub-cortical and brainstem structures that are functionally distinct. Despite having been derived from purely functional data, this atlas broadly, if not precisely, correlates with the general anatomical boundaries and many are associated with specific anatomical structures. A primary motivation for the creation of this atlas is derived from the need to perform brain segmentations which is optimized for functional MRI analysis, since the signal sources do not necessarily match typical anatomical boundaries. A similar requirement has been identified by those performing human studies, resulting in efforts to generate more diverse, multi-modal atlases.</p> <p>SIGMA rat brain functional atlas normalized in in-vivo T2 SIGMA functional template + List of 59 labels created in ITKSnap Format.</p> <p>Spatial resolution 0.375x1x0.375mm.</p> <div> <pre><code> SIGMA_Functional_Brain_Atlas_Labels.txt SIGMA_Functional_Brain_Atlas_ListOfStructures.csv SIGMA_InVivo_Functional_Brain_Atlas.nii.gz </code></pre> <div> </div> </div> <h4><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#sigma-cttep-template"></a></h4> <h4>SIGMA CT/TEP template</h4> <p>In this version of the SIGMA resources we included a CT/TEP template built from the data that previously published (Barriere D.A. et al 2018 , Sci Rep. 2018 Jan 11;8(1):424. doi: 10.1038/s41598-017-18896-5) and acquired on a Triumph™ PET/CT dual modality imaging platform (Gamma Medica, Inc., Northridge, CA, USA), consisting of a LabPET™ avalanche photodiode-based digital PET scanner with a 7.5 cm axial field-of-view capable of achieving an isotropic spatial resolution. A caudal injection of approximately 30 MBq of [18F]-FDG was applied followed by a static acquisition to evaluate [18F]-FDG uptake within brain. CT images were acquired from the high-resolution X-ray computed tomography (CT) modality. Images were reconstructed using the Triumph™ PET/CT software. using the following parameters: 20 iterations, span of 63, field of view of 80 mm with a final matrix resolution of 160 × 160 × 128 and a voxel size of 0.5 × 0.5 × 0.597 mm. Brain dynamic [18F]-FDG images were reconstructed using the same protocol but we generated 32 frames (10 for 5 s, 7 for 10 s, 6 for 30 sec, 6 for 120 s, 2 for 240 s and 1 for 300 s). [18F]-FDG images were reconstructed using 3-D MLEM algorithm providing 0.5 × 0.5 × 0.597 mm images. CT scans were reconstructed using the standard FBP kernel analytical reconstruction algorithms, providing an isotropic image of 512 slices with a final resolution of 0.165 µm isotropic. Both [18F]-FDG and CT data were spatially normalized to the SIGMA ex-vivo template using the previously described methods.</p> <p>Spatial resolution 0.09x0.09x0.09mm.</p> <div> <pre><code> SIGMA_InVivo_18FDG_Brain_template.nii.gz SIGMA_InVivo_CT_Brain_template.nii.gz </code></pre> <div> </div> </div> <h2><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#important-note"></a></h2> <h2>Important Note</h2> <p>SIGMA ressources are provided at the scanner resolution and are oriented in anterior commisure/posterior commisure axis. Center of the images have been set at the anterior commisure level (Bregma 0 mm). Nevertheless, users are invited to increase the resolution of the current images for using in SPM or FSL for accurate coregistration and normalization steps (we recommand x10 increasing). No manipulation of image resolution are required with ANTs. Not tested with AFNI.</p> <p>For any questions regarding the SIGMA ressource, please email the SIGMA Team (<a href="mailto:sigma.preclinical.resources@gmail.com">sigma.preclinical.resources@gmail.com</a>) or Email directly David A. Barrière (<a href="mailto:david.barriere@cnrs.fr">david.barriere@cnrs.fr</a>).</p> <h1><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#references"></a></h1> <h1>REFERENCES</h1> <p>Barrière, D.A. et al. The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization. Nat Commun 10, 5699 (2019). <a href="https://doi.org/10.1038/s41467-019-13575-7" rel="nofollow">https://doi.org/10.1038/s41467-019-13575-7</a><a title="La ressource a été trouvée dans UNPAYWALL" href="https://www.nature.com/articles/s41467-019-13575-7.pdf" target="_blank" rel="noopener"></a></p> <p>Kleven, H. et al. Waxholm Space atlas of the rat brain: a 3D atlas supporting data analysis and integration. Nat Methods 20, 1822–1829 (2023). <a href="https://doi.org/10.1038/s41592-023-02034-3" rel="nofollow">https://doi.org/10.1038/s41592-023-02034-3</a></p> <p>Barrière, D.A. et al. Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications. Sci Rep. 2018 Jan 11;8(1):424. doi: 10.1038/s41598-017-18896-5. PMID: 29323186; PMCID: PMC5765114.</p> <h1><a href="https://github.com/DavidBarriere/SIGMA-Rat-Brain-Templates-and-Atlases#related-works-using-the-sigma-ressources"></a></h1> <h1>RELATED WORKS USING THE SIGMA RESSOURCES</h1> <p>Grandjean J. et al. A consensus protocol for functional connectivity analysis in the rat brain. Nat Neurosci. 2023 Apr;26(4):673-681. doi: 10.1038/s41593-023-01286-8. Epub 2023 Mar 27. Erratum in: Nat Neurosci. 2023 Jun;26(6):1127-1128. PMID: 36973511; PMCID: PMC10493189.</p> <p>Vidal B. et al. Inter-subject registration and application of the SIGMA rat brain atlas for regional labeling in functional ultrasound imaging. J Neurosci Methods. 2021 May 1;355:109139. doi: 10.1016/j.jneumeth.2021.109139. Epub 2021 Mar 16. PMID: 33741345.</p> <p>Barrière D.A. et al. Paracetamol is a centrally acting analgesic using mechanisms located in the periaqueductal grey. Br J Pharmacol. 2020 Apr;177(8):1773-1792. doi: 10.1111/bph.14934. Epub 2020 Jan 22. PMID: 31734950; PMCID: PMC7070177</p> <p>Barrière D.A. et al. Structural and functional alterations in the retrosplenial cortex following neuropathic pain. Pain. 2019 Oct;160(10):2241-2254. doi: 10.1097/j.pain.0000000000001610. PMID: 31145220.</p> <p>Magalhães, R. et al Resting-State Functional MR Imaging and Spectroscopy Study of the Dorsal Hippocampus in the Chronic Unpredictable Stress Rat Model. J Neurosci. 2019 May 8;39(19):3640-3650. doi: 10.1523/JNEUROSCI.2192-18.2019. Epub 2019 Feb 25. PMID: 30804096; PMCID: PMC6510342.</p> <p>Magalhães, R. et al The dynamics of stress: a longitudinal MRI study of rat brain structure and connectome. Mol Psychiatry. 2018 Oct;23(10):1998-2006. doi: 10.1038/mp.2017.244. Epub 2017 Dec 5. PMID: 29203852.</p>
A Non-interventional, International, Multicentre Clinical Research Study to Build the Largest Collection of Multimodal Data (Including Clinical Data, Imaging Data and Omics Data) in Oncology
ClinicalTrials.gov study NCT06625203. IPD Sharing: YES. Countries: 4. Publications: 7.
Data for: Multimodal convergence in the pedunculopontine tegmental nucleus: motor, sensory, and theta-frequency inputs influence the activity of single neurons
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Release of cognitive and multimodal MRI data including real-world tasks and hippocampal subfield segmentations
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