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29 results for “Myostatin”
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight [plasma proteomics]
Among the physiological consequences of extended spaceflight are loss of skeletal muscle and bone mass. One signaling pathway that plays an important role in maintaining muscle and bone homeostasis is that regulated by the secreted signaling proteins, myostatin (MSTN) and activin A. Here, we used both genetic and pharmacological approaches to investigate the effect of targeting MSTN/activin A signaling in mice that were sent to the International Space Station. Wild type mice lost significant muscle and bone mass during the 33 d spent in microgravity. Muscle weights of Mstn -/- mice, which are about twice those of wild type mice, were largely maintained during spaceflight. Systemic inhibition of MSTN/activin A signaling using a soluble form of the activin type IIB receptor (ACVR2B), which can bind each of these ligands, led to dramatic increases in both muscle and bone mass, with effects being comparable in ground and flight mice. Exposure to microgravity and treatment with the soluble receptor each led to alterations in numerous signaling pathways, which were reflected in changes in levels of key signaling components in the blood as well as their RNA expression levels in muscle and bone. These findings have implications for therapeutic strategies to combat the concomitant muscle and bone loss occurring in people afflicted with disuse atrophy on Earth as well as in astronauts in space, especially during prolonged missions.
The Possible Role of Complete Loss of Myostatin in Limiting Excessive Proliferation of Muscle Cells (C2C12) via Activation of MicroRNAs (mRNA-seq)
GEO Series GSE124195. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Skeletal muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis
GEO Series GSE275041. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
The Possible Role of Complete Loss of Myostatin in Limiting Excessive Proliferation of Muscle Cells (C2C12) via Activation of MicroRNAs (miRNA-seq)
GEO Series GSE124194. Mus musculus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
The Possible Role of Complete Loss of Myostatin in Limiting Excessive Proliferation of Muscle Cells (C2C12) via Activation of MicroRNAs
GEO Series GSE124196. Mus musculus. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
The FSHD effector protein Dux promotes myopathy via Myostatin-Smad signaling
GEO Series GSE108828. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Effects of wheel running exercise and myostatin depletion on skeletal muscle gene expression in mice
GEO Series GSE31844. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Myostatin Increases Trophoblast Cell Invasion Through Regulating Epithelial Mesenchymal Transition Genes
GEO Series GSE225378. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Tibialis anterior muscle of myostatin null mice treated with clenbuterol
GEO Series GSE27577. Mus musculus. 8 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.