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datasets available to search
ShareScore release 0.9.0
Dataset results
40 results for “Neuron Damage”
Secreted neurofilament light chain (NfL) after neuronal damage induces myeloid cell activation and neuroinflammation [scRNA-Seq]
GEO Series GSE287769. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Adamantinomatous craniopharyngioma cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamic neurons by inducing the production of β-amyloid
GEO Series GSE206861. Homo sapiens; Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Macrophages amplify damaged sensory neuron spontaneous activity in a human co-culture model of neuropathic pain [human]
GEO Series GSE298325. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing; Other.
Figure 1 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 1 Western blotting analysis and relative expression of GSDMD to Beta Actin.
Data from: Progression of neuronal damage in an in vitro model of the ischemic penumbra
Improvement of neuronal recovery in the ischemic penumbra around a brain infarct has a large potential to advance clinical recovery of patients with acute ischemic stroke. However, pathophysiological mechanisms leading to either recovery or secondary damage in the penumbra are not completely understood. We studied neuronal dynamics in a model system of the penumbra consisting of networks of cultured cortical neurons exposed to controlled levels and durations of hypoxia. Short periods of hypoxia (pO2≈20mmHg) reduced spontaneous activity, due to impeded synaptic function. After ≈6 hours, activity and connectivity partially recovered, even during continuing hypoxia. If the oxygen supply was restored within 12 hours, changes in network connectivity were completely reversible. For longer periods of hypoxia (12–30 h), activity levels initially increased, but eventually decreased and connectivity changes became partially irreversible. After ≈30 hours, all functional connections disappeared and no activity remained. Since this complete silence seemed unrelated to hypoxic depths, but always followed an extended period of low activity, we speculate that irreversible damage (at least partly) results from insufficient neuronal activation. This opens avenues for therapies to improve recovery by neuronal activation.
Neuronal Damage In Delirium Study
ClinicalTrials.gov study NCT03724201. IPD Sharing: NO. Countries: 1. Publications: 0.
Noninvasive Assessment of Neuronal Damage by MRI Sodium ( 23Na ) in Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT02874209. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Progression of neuronal damage in an in vitro model of the ischemic penumbra
Open the record for dataset details and reuse information.
Preeclamptic placentae release factors that damage neurons in vitro
GEO Series GSE110786. Homo sapiens. 23 samples. Type: Other.
Immunomodulation with minocycline rescues retinal degeneration in juvenile neuronal ceroid lipofuscinosis (jNCL) mice highly susceptible to light damage
GEO Series GSE118664. Mus musculus. 10 samples. Type: Expression profiling by array.
p53 drives premature neuronal differentiation in response to acute DNA damage during early neurogenesis
GEO Series GSE140464. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
GEO Series GSE74724. Mus musculus. 52 samples. Type: Expression profiling by high throughput sequencing.
PROtection MEdiated by Antioxidant NanoTEchnOlogy Against Neuronal Damage in Space (PROMETEO, Antioxidant Protection)
GEO Series GSE290701. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-Juvenile Neuronal Ceroid Lipofuscinosis
GEO Series GSE137420. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at th earliest stages of Alzheimer-type pathology
GEO Series GSE66333. Homo sapiens. 8 samples. Type: Expression profiling by array.
Single-cell transcriptome comparison of myeloid cells’ in the retina in response to transplantation of human stem-cell derived neurons and to ocular damage reveals the reversibility of the microglia a
GEO Series GSE285564. Homo sapiens; Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
The Neuronal CCAAT/enhancer binding protein α mediates HIF-1α-induced inflammatory brain damage after ischemia
GEO Series GSE81919. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
GEO Series GSE314471. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Disease Associated Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage and cell survival in a 5XFAD mouse model.
GEO Series GSE287470. Mus musculus. 48 samples. Type: Other.
Persistent accumulation of unrepaired DNA damage in rat cortical neurons: nuclear organization and ChIP-seq analysis of damaged DNA
GEO Series GSE112930. Rattus norvegicus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.