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224 results for “Neurotoxicity”
Envarsus Neurotoxicity Burden in Liver Transplant Patients
ClinicalTrials.gov study NCT03823768. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Bilirubin Neurotoxicity (BN) and Neurodevelopmental Impairment (NDI) in Extremely Preterm (EP) Infants: Avoidable by Reducing the Usual Intravenous Lipid (UL) Administration
ClinicalTrials.gov study NCT04584983. IPD Sharing: NO. Countries: 1. Publications: 2.
A Safety and Efficacy Study of Defibrotide in the Prevention of Chimeric Antigen Receptor-T-cell-associated Neurotoxicity
ClinicalTrials.gov study NCT03954106. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Non-Pharmacological Interventions for Neurotoxicity in Hematologic Patients Receiving CAR-T Therapy
ClinicalTrials.gov study NCT07173166. IPD Sharing: NO. Countries: 1. Publications: 4.
Study to Assess Prevention of Oxaliplatin-induced Neurotoxicity Through Vitamin D Pathway
ClinicalTrials.gov study NCT01499940. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy
ClinicalTrials.gov study NCT01099449. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Differences in neurotoxic outcomes of organophosphorus pesticides revealed via multi-dimensional screening in adult and regenerating planarians
Open the record for dataset details and reuse information.
Data from: Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder
Introduction Bipolar disorder (BD) is a chronic psychiatric disease which can take most different and unpredictable courses. It is accompanied by unspecific brainstructural changes and cognitive decline. The neurobiological underpinnings of these processes are still unclear. Emerging evidence suggests that tryptophan catabolites (TRYCATs), which involve all metabolites of tryptophan towards the kynurenine (KYN) branch, are involved in the etiology as well as in the course of BD. They are proposed to be mediators of immune-inflammation and neurodegeneration. In this study we measured the levels of KYN and its main catabolites consisting of the neurotoxic hydroxykynurenine (3-HK), the more neuroprotective kynurenic acid (KYNA) and anthranilic acid (AA) and evaluated the ratios between end-products and substrates as proxies for the specific enzymatic activity (3-HK/KYN, KYNA/KYN, AA/KYN) as well as 3-HK/KYNA as a proxy for neurotoxic vs. neuroprotective end-product relation in individuals with BD compared to healthy controls (HC). Methods We took peripheral TRYCAT blood levels of 143 euthymic to mild depressive BD patients and 101 HC. For statistical analyses MANCOVA's controlled for age, sex, body mass index, cardiovascular disease and smoking were performed. Results The levels of KYNA (F=5,579; p<.05) were reduced in BD compared to HC. The enzymatic activity of the kynurenine-3-monooxygenase (KMO) reflected by the 3-HK/KYN ratio was increased in BD individuals compared to HC (F=5,394; p<.05). Additionally the ratio of 3-HK/KYNA was increased in individuals with BD compared to healthy controls (F=11,357; p<.01). Discussion In conclusion our findings subserve the concept of KYN -pathway alterations in the pathophysiology of BD. We present evidence of increased breakdown towards the neurotoxic branch in KYN metabolism even in a euthymic to mild depressive state in BD. From literature we know that depression and mania are accompanied by inflammatory states which should be capable to produce an even greater imbalance due to activation of key enzymes in the neurotoxic direction of KYN -conversion. These processes could finally be involved in the development of unspecific brain structural changes and cognitive deficits which are prevalent in BD. Further research should focus on state dependent changes in TRYCATs and its relation to cognition, brain structure and staging parameters.
Raw data and concentration response curves for: Neurotoxic mixture effects of chemicals extracted from blood of pregnant women
<p>The raw data and concentration response curves of the single chemicals, sample extracts, blanks and controls, as well as designed mixtures. The assay was a neurite outgrowth inhibition assay based on the SH-SY5Y neuroblastoma cell line. Reported endpoints were neurite outgrowth inhibition relative to unexposed cells (%), and cytotoxicity relative to unexposed cells (%). </p>
FLUOROQUINOLONE NEUROTOXICITY IN THE ELDERLY
<p>Older patients are taking more and more antibiotics, including fluoroquinolones. Their toxic effects on the<br>nervous system and the psyche are well known but not well described and explained. We sought to<br>determine the number and severity of adverse effects on the nervous system and psyche caused by<br>fluoroquinolones in patients over 65 years of age. We analyzed fluoroquinolone reports submitted to the<br>Canada Vigilance Adverse Reaction Online Database and the Australian Database of Adverse Event<br>Notification. A systematic literature search was also conducted. Confusion and hallucinations were the<br>predominant symptoms caused primarily by ciprofloxacin. The review of the publications indicates an<br>increased incidence of adverse effects on the nervous system in the elderly. Treatment with<br>fluoroquinolones in the elderly should be closely monitored due to the potential for neurotoxicity<br>manifesting as neurological and/or psychiatric symptoms and the risk of misdiagnosis.</p>
NEUROTOX: Two Dosages of Type A Botulinic Toxin in Neurogenic Overactive Bladder
ClinicalTrials.gov study NCT00213577. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of GM1 in Prevention of Oxaliplatin Induced Neurotoxicity in Stage II/III Colorectal Cancer
ClinicalTrials.gov study NCT02251977. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neurotoxicity of Spinal Anesthesia With Ropivacaine and Bupivacaine
ClinicalTrials.gov study NCT03293472. IPD Sharing: NO. Countries: 1. Publications: 3.
Intrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT05519579. IPD Sharing: UNDECIDED. Countries: 1. Publications: 9.
Neurotoxic Symptoms in Adjuvant Chemotherapy in Patients With Colorectal Cancer
ClinicalTrials.gov study NCT02412683. IPD Sharing: Not stated. Countries: 1. Publications: 1.
the Effect of ABCC2 Genetic Polymorphism on Neurotoxicity in Gastrointestinal Cancer Patients Receiving Oxaliplatin
ClinicalTrials.gov study NCT05494320. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Biomarkers in Chemotherapy-Induced Peripheral Neurotoxicity
ClinicalTrials.gov study NCT03348956. IPD Sharing: NO. Countries: 1. Publications: 0.
Prospective Observational Pilot-study for the Evaluation of the Nephro- an Neurotoxicity in the Anti-infectious Therapy With Inhalative Colistin Therapy for Patients With Ventilator-associated Pneumon
ClinicalTrials.gov study NCT01894347. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Pharmacogenomic Study to Predict Neurotoxicity of Oxaliplatin
ClinicalTrials.gov study NCT00977717. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of the Efficacy of Xaliproden (SR57746A) in Preventing the Neurotoxicity of Oxaliplatin / 5FU/LV Chemotherapy.
ClinicalTrials.gov study NCT00305188. IPD Sharing: Not stated. Countries: 13. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.