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datasets available to search
ShareScore release 0.9.0
Dataset results
24 results for “Object recognition”
Spatial RNA sequencing of mouses brain slices following spatial object recognition training
GEO Series GSE201610. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures (Elevated Plus Maze, Novel Object Recognition, Open Field, Radial Arm Water Maze, and Three Chamber Social Isolation/Interaction)
In the coming decade, astronauts will travel back to the moon in preparation for future Mars missions. Exposure to galactic cosmic radiation (GCR) is a major obstacle for deep space travel. Using multivariate principal components analysis, we found sex dimorphic responses in mice exposed to accelerated charged particles to simulate GCR (GCRsim); males displayed impaired spatial learning, whereas females did not. Mechanistically, these GCRsim induced learning impairments corresponded with chronic microglia activation and synaptic alterations in the hippocampus. Temporary microglia depletion shortly after GCRsim exposure mitigated GCRsim induced deficits measured months after the radiation exposure. Furthermore, blood monocyte levels measured early after GCRsim exposure were predictive of the late learning deficits and microglia activation measured in the male mice. Our findings (i) advance our understanding of charged particle induced cognitive challenges, (ii) provide evidence for early peripheral biomarkers for identifying late cognitive deficits, and (iii) offer potential therapeutic strategies for mitigating GCR induced cognitive loss. This study derives results from the behavior assays Elevated Plus Maze, Novel Object Recognition, Open Field, Radial Arm Water Maze, and Three Chamber Social Isolation/Interaction. These data are related to the Flow Cytometry data in OSD-776 (blood), OSD-777 (Microglia), and OSD-778 (Synapse).
Effects of heavy particle irradiation and diet on object recognition memory in rats
On long-duration missions to other planets astronauts will be exposed to types and doses of radiation that are not experienced in low earth orbit. Previous research using a ground-based model for exposure to cosmic rays has shown that exposure to heavy particles, such as 56Fe, disrupts spatial learning and memory measured using the Morris water maze. Maintaining rats on diets containing antioxidant phytochemicals for 2 weeks prior to irradiation ameliorated this deficit. The present experiments were designed to determine: (1) the generality of the particle-induced disruption of memory by examining the effects of exposure to 56Fe particles on object recognition memory; and (2) whether maintaining rats on these antioxidant diets for 2 weeks prior to irradiation would also ameliorate any potential deficit. The results showed that exposure to low doses of 56Fe particles does disrupt recognition memory and that maintaining rats on antioxidant diets containing blueberry and strawberry extract for only 2 weeks was effective in ameliorating the disruptive effects of irradiation. The results are discussed in terms of the mechanisms by which exposure to these particles may produce effects on neurocognitive performance. This study derives behavior results from the novel object recognition assay. The original data derived from this study by Rabin et al. was transformed and used as part of a predictive modeling study by Dr. Mora, Dr. Wyrobek, Dr. Ben Brown et al. The study files contain both the original data and the transformed data produced by both research teams. For questions regarding the original study data and methods/assays, please contact the original study investigator and publication author Dr. Bernard Rabin (rabin@umbc.edu). For questions about the predictive modeling data files or how they were generated, please contact Dr. Mora (animora@berkeley.edu).
Mbnl2 loss alters novel context processing and impairs object recognition memory
GEO Series GSE226191. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.