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39 results for “Omicron variant”
Exploring Conformational Landscapes and Binding Mechanisms of Convergent Evolition for the SARS-CoV-2 Spike Omicron Variant Complexes with the ACE2 Receptor Using AlphaFold2-Based Structural Ensembles and Molecular Dynamics Simulations
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AlphaFold2 Modeling and Molecular Dynamics Simulations of the Conformational Ensembles for the SARS-CoV-2 Spike Omicron JN.1, KP.2 and KP.3 Variants : Mutational Profiling of Binding Energetics Reveals Epistatic Drivers of the ACE2 Affinity and Escape Hotspots of Antibody Resistance
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Nasally-delivered interferon-λ in mice protects against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron
GEO Series GSE193990. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Effects of Ancestral SARS-CoV-2 versus Variants of Concern Delta and Omicron on Megakaryocyte Activation and Transcriptome
GEO Series GSE277576. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Comparison of SARS-CoV-2 variants in primary human nasal cultures indicates Delta as most cytopathic and Omicron as fastest replicating
GEO Series GSE250155. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Heterologous immunization with inactivated vaccine followed by mRNA booster elicits strong humoral and cellular immune responses against the SARS-CoV-2 Omicron variant
<p>The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and the urgent need to study more efficient vaccination strategies. Here we evaluated the effect of an mRNA vaccine booster on immunogenicity in individuals vaccinated with two doses of inactivated vaccine. We observed that an mRNA vaccine booster significantly increased the plasma level of specific antibodies that bind to the receptor-binding domain (RBD) or the spike (S) ectodomain (S1+S2) of both the G614 and the Omicron variants, compared to two doses of homologous inactivated vaccine. The level of RBD- and S-specific IgG antibodies and virus neutralization titers against variants of concern in the heterologous vaccination group were similar to that in individuals receiving three doses of homologous mRNA vaccine or a boost of mRNA vaccine after infection, but markedly higher than that in individuals receiving three doses of a homologous inactivated vaccine. Moreover, this heterologous vaccination regime significantly enhanced the RBD-specific memory B cell response and S1-specific T cell response compared to two or three doses of homologous inactivated vaccine. Our study demonstrates that an mRNA vaccine booster in individuals vaccinated with inactivated vaccines can be highly beneficial, as it markedly increases the humoral and cellular immune responses against the virus, including the Omicron variant</p>
Efficacy and Safety of Nirmatrelvir/Ritonavir for Treating Omicron Variant of COVID-19
ClinicalTrials.gov study NCT05813600. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Preliminary Exploratory Cohort Study of SARS-CoV-2 Variant (Omicron BA.5) mRNA Vaccine in Participants Aged 18 Years and Over in China
ClinicalTrials.gov study NCT05550142. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Preliminary Exploratory Study to Evaluate the Safety and Immunogenicity of Omicron Variant Bivalent Vaccine V-01-B5
ClinicalTrials.gov study NCT05585567. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Evaluate the Safety, Tolerability, and Immunogenicity of SARS-CoV-2 Variant (COVID-19 Omicron) mRNA Vaccine (Phase 1)
ClinicalTrials.gov study NCT05433194. IPD Sharing: NO. Countries: 1. Publications: 0.
Efficacy of Lianhua Qingwen in Treating Patients Infected With the Omicron Variant of the COVID-19
ClinicalTrials.gov study NCT05778318. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Echocardiographic Manifestation in Patients With Omicron Variant of COVID-19
ClinicalTrials.gov study NCT05379543. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Long Covid After COVID-19 Infection With Omicron Variant
ClinicalTrials.gov study NCT05234294. IPD Sharing: NO. Countries: 1. Publications: 0.
Limited cross-variant immune response from SARS-CoV-2 Omicron BA.2 in naïve but not previously infected outpatients
GEO Series GSE205244. Homo sapiens. 56 samples. Type: Expression profiling by high throughput sequencing.
A Cohort Study of SARS-CoV-2 Variant (Omicron BA.5) mRNA Vaccine in Participants Aged 18 Years and Over in Chinese People
ClinicalTrials.gov study NCT05549206. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Profiling of human monoclonal antibodies targeting SARS-CoV-2 Omicron variant
GEO Series GSE203030. Mus musculus. 3 samples. Type: Other.
SARS-CoV-2 infection of Lung Organoids Reveals Conserved Use of Tetraspanin-8 by Ancestral-, Delta-, and Omicron- Variants
GEO Series GSE211562. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Two-component intranasal vaccine against SARS-CoV-2 Omicron variant
GEO Series GSE279004. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
Phytochemicals from AYUSH-64 screened against main protease and spike protein of Omicron variant of SARS-CoV-2 using ensemble docking and molecular dynamics approach
<p>Data for "Phytochemicals from AYUSH-64 screened against main protease and spike protein of Omicron variant of SARS-CoV-2 using ensemble docking and molecular dynamics approach" </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.