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Study of Human Placenta-derived Cells (PDA002) to Evaluate the Safety and Effectiveness in Subjects With PAD and DFU

ClinicalTrials.gov study NCT01859117. IPD Sharing: Not stated. Countries: 1. Publications: 1.

controlledIPD-YESFeb 2026View details →

Psychological Outcome of Women With Morbidly Adherent Placenta Following Hystrectomy

ClinicalTrials.gov study NCT03976453. IPD Sharing: YES. Countries: 1. Publications: 8.

Maternal Outcomes Following Manual Lysis of the Placenta.

ClinicalTrials.gov study NCT03626844. IPD Sharing: UNDECIDED. Countries: 1. Publications: 8.

A Multi-Center Study to Evaluate the Safety and Efficacy of Intravenous Infusion of Human Placenta-Derived Cells (PDA001) for the Treatment of Adults With Moderate-to-Severe Crohn's Disease

ClinicalTrials.gov study NCT01155362. IPD Sharing: Not stated. Countries: 1. Publications: 0.

closedIPD-NOFeb 2026View details →

Histerectomy Vs Partial Myometrial Resection for Placenta Accreta Spectrum

ClinicalTrials.gov study NCT05013749. IPD Sharing: NO. Countries: 1. Publications: 19.

closedIPD-NOFeb 2026View details →

Comparison of Oxytocin Receptor Immunoreactivity in Placentas Obtained From Women Having Cesarean and Natural Birth

ClinicalTrials.gov study NCT06275438. IPD Sharing: NO. Countries: 1. Publications: 6.

closedIPD-NOFeb 2026View details →

Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study

ClinicalTrials.gov study NCT02806024. IPD Sharing: NO. Countries: 1. Publications: 3.

A Multicener, Postmarketing Study Evaluating the Transfer of Cimzia From the Mother to the Infant Via the Placenta

ClinicalTrials.gov study NCT02019602. IPD Sharing: Not stated. Countries: 4. Publications: 1.

publicFeb 2020View details →

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The oxytocin-prostaglandins pathways in the horse (Equus caballus) placenta during pregnancy, physiological parturition, and parturition with fetal membrane retention

Open the record for dataset details and reuse information.

opencc-by-4.0Feb 2021View details →

Revisiting steroidogenic pathways in the human placenta and primary human trophoblast cells

Supplementary Table (Table S1)

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Data from: Umbilical vein oxytocin for the treatment of retained placenta (Release Study): a double-blind, randomised controlled trial.

BACKGROUND: Retained placenta is associated with post-partum haemorrhage. Meta-analysis has suggested that umbilical injection of oxytocin could increase placental expulsion without the need for a surgeon or anaesthetic. We assessed the effect of high-dose umbilical vein oxytocin as a treatment for retained placenta. METHODS: In this double-blind, placebo-controlled trial, haemodynamically stable women with a retained placenta for more than 30 min were recruited from 13 sites in the UK, Uganda, and Pakistan. 577 women were randomly assigned by a computer-generated randomisation list stratified by centre to 30 mL saline containing either 50 IU oxytocin (n=292) or 5 mL water (n=285), which was injected into the placenta through an umbilical vein catheter. All trial participants, study workers, and data handlers were masked to individual allocations. The primary outcome was the need for manual removal of the placenta. Analysis was by intention to treat. This study is registered, number ISRCTN 13204258. FINDINGS: The primary outcome was recorded for all participants. We detected no difference between the groups in the need for manual removal of placenta (oxytocin 179/292 [61.3%] vs placebo 177/285 [62.1%]; relative risk 0.98, 95% CI 0.87-1.12; p=0.84). The need for manual removal was higher in the UK (overall 250/361 [69%]) than in Uganda (90/190 [47%]) or Pakistan (16/26 [62%]). Adverse events did not differ between the two groups. INTERPRETATION: Umbilical oxytocin has no clinically significant effect on the need for manual removal for women with retained placenta. FUNDING: WHO, WellBeing of Women, Pakistan Higher Education Commission.

opencc-zeroDec 2014View details →

opencc-by-4.0Dec 2023View details →

Global Transcriptomic Analysis of Placenta from Women with Gestational SARS-CoV-2 Infection during the 3rd Trimester of Pregnancy

Supplementary data for Global Transcriptomic Analysis of Placenta from Women with Gestational SARS-CoV-2 Infection during the 3rd Trimester  of Pregnancy

opencc-by-4.0Feb 2024View details →

HAPPY: a deep learning pipeline for mapping cell-to-tissue graphs across placenta histology whole slide images

These two zipped folders contain all data necessary to train, validate and reproduce results from the paper. Unzipping the files will create 6 folders. Data from folders with the same name across both zips should be combined into one folder. The 'annotations' folder contains all ground truth annotations for training all three deep learning models. The 'datasets' folder contains images for training the nuclei localisation and cell classification models. The 'embeddings' folder contains cell embedding vectors and nuclei coordinates from two slides used to create nodes to train the graph tissue classification model. The 'graph_splits' folder contains regions defining the validation and test splits for the graph model. The 'slides' folder contains a sample region of a whole slide image as a .tiff file for running the inference demo. The 'trained_models' folder contains trained weights for each of the three models. Further instructions for dataset use and creation of custom datasets are available in the GitHub readme: https://github.com/Nellaker-group/happy.

opencc-by-4.0Oct 2021View details →

Differential Proteomics of Placentas Revels Metabolic Disturbance and Oxidative Stress Participate Spontaneous Abortion during Late Pregnancy in Yak

Supplementary tables used for a article titled "Differential Proteomics of Placentas Revels Metabolic Disturbance and Oxidative Stress Participate Spontaneous Abortion during Late Pregnancy in Yak"

opennotspecifiedMar 2022View details →

FIGURE. Floral habit and structure of C. spongifolia. A. Type specimen in situ with open, spathe limb (apex is reflexed out of view), and green spathe tube (ca. 6 cm long). B. Adjacent plant with inflorescences and prophylls. C. Spadix showing from top: sterile appendix, staminate (male) zone, sterile interstice, and green pistillate (female) zone with tapered, conical form. D. Detail of female zone showing a few basal staminodes. E–G. Berries of the preserved type specimen. G. Dissected berry with orthotropous ovules (some outlined) attached by funicles to parietal placentae (arrows). H. Surface of male zone showing closely-packed synandria. I. Synandria separated to show fused anther sacs beneath apical pores (example in center has 8 pores, 8 anthers) J. Mature fruiting head, with single berry removed to show seed packing and 67 seeds extracted (scale bar units: 1 mm) (Bach Ma NP; type 2020; fruit and seeds 2018). Photos: NVD and PJM. in Colocasia spongifolia sp. nov. (Araceae) in southern China and central Vietnam

FIGURE. Floral habit and structure of C. spongifolia. A. Type specimen in situ with open, spathe limb (apex is reflexed out of view), and green spathe tube (ca. 6 cm long). B. Adjacent plant with inflorescences and prophylls. C. Spadix showing from top: sterile appendix, staminate (male) zone, sterile interstice, and green pistillate (female) zone with tapered, conical form. D. Detail of female zone showing a few basal staminodes. E–G. Berries of the preserved type specimen. G. Dissected berry with orthotropous ovules (some outlined) attached by funicles to parietal placentae (arrows). H. Surface of male zone showing closely-packed synandria. I. Synandria separated to show fused anther sacs beneath apical pores (example in center has 8 pores, 8 anthers) J. Mature fruiting head, with single berry removed to show seed packing and 67 seeds extracted (scale bar units: 1 mm) (Bach Ma NP; type 2020; fruit and seeds 2018). Photos: NVD and PJM.

opennotspecifiedJan 2014View details →

FIGURE 1. A–F. Utricularia julianae. A. Habit. B. Flower, lateral view. C. Flower, posterior view. D. Calyx, posterior view. E. Dehisced capsule, with barely protruding placenta. F. Trap, lateral view. G–K. Utricularia tenuissima. G. Flower, lateral view. H. Flower, posterior view. I. Calyx, posterior view. J. Dehisced capsule, with protruding placenta. K. Trap, lateral view. A–F in Utricularia julianae (Lentibulariaceae), a new species from the savannas of the Oyapock River, French Guiana

FIGURE 1. A–F. Utricularia julianae. A. Habit. B. Flower, lateral view. C. Flower, posterior view. D. Calyx, posterior view. E. Dehisced capsule, with barely protruding placenta. F. Trap, lateral view. G–K. Utricularia tenuissima. G. Flower, lateral view. H. Flower, posterior view. I. Calyx, posterior view. J. Dehisced capsule, with protruding placenta. K. Trap, lateral view. A–F: drawn from Delprete 12160; G–K: redrawn from Taylor, 1989, fig. 67. Illustration by Piero G. Delprete.

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Micro-anatomic alterations of the placenta in a non-human primate model of gestational protein-restriction

Objectives: Maternal protein malnutrition is associated with impaired fetal growth, and lifetime consequences for the offspring. Our group has previously developed a model of protein-restriction in the non-human primate, which was associated with fetal growth restriction, stillbirth, decreased placental perfusion, and evidence of fetal hypoxia, suggesting perturbed vascular development. Previous assessments of placental vasculature have relied upon stereological or vascular casting methods, but these methods have limitations. Our objective was to histologically characterize the micro-anatomic alterations associated with adverse pregnancy outcomes using a newer method that permits investigation of the 3D vascular structure and surrounding histology. Methods: Rhesus macaques were assigned in the pre-gestational period to a control diet that contained 26% protein, or study diet containing 13% protein (50% PR diet). Placental tissue was collected at delivery and processed using a clarification, immunohistochemistry, and confocal microscopy protocol published previously by our group. 3-dimensional reconstructions and quantitative analysis of the vascular micro-anatomy was performed using analysis software (Imaris®) and statistical analysis incorporated maternal, pregnancy, and perinatal outcomes. Results: In unadjusted analysis, when comparing those pregnancies on a 50% PR diet (n=4) with those on a control diet (n=4), protein-restriction diet was associated with decreased maternal pre-pregnancy weight (difference of -1.975kg, 95% CI -3.267 to -0.6826). When controlling for maternal pre-pregnancy weight, fetal sex, and latency from tissue collection to imaging, a gestational protein-restriction diet was associated with decreases in total vascular length, total vascular surface area, total vascular volume, and vascular density. Conclusion: In this pilot study, a gestational protein-restriction diet was associated with changes in the placental micro-vasculature, which may be related to the observed adverse pregnancy outcomes and perturbed placental perfusion demonstrated in this model.

opencc-zeroSep 2021View details →

opennotspecifiedMay 2021View details →

FIGURE. Flowers and longitudinal sections of ovaries of Hylaeaicum and Neoregelia. A–K. Hylaeaicum. A. H. eleutheropetalum (Leme 4491). B. H. myrmecophilum (Leme 2555). C. H. aff. myrmecophilum (Leme 3487). D. H. levianum (Leme 2777). E. H. wurdackii (Leme 2567). F. H. pendulum (Leme 1979). G. H. wurdackii (Leme 2567). H. H. aff. myrmecophilum (Leme 2553). I. H. pendulum (Leme 1979). J. H. eleutheropetalum (Leme 4491). K. H. levianum (Leme 5639-A) highlighting the immature seeds connected to the placenta. L–P. Neoregelia subg. Neoregelia. L–M. N. binotii (Leme 3482). N. N. ampullacea (Leme 9299). O–P. N. pontualii (Leme 5520). Q–S. Neoregelia subg. Longipetalopsis. Q–R. N. rubrovittata (Leme 1865). S. N. pernambucana (Leme 4407). Bars = 10 mm (A–F, L–S), 5 mm (G–K). in Re-evaluation of the Amazonian Hylaeaicum (Bromeliaceae: Bromelioideae) based on neglected morphological traits and molecular evidence

FIGURE. Flowers and longitudinal sections of ovaries of Hylaeaicum and Neoregelia. A–K. Hylaeaicum. A. H. eleutheropetalum (Leme 4491). B. H. myrmecophilum (Leme 2555). C. H. aff. myrmecophilum (Leme 3487). D. H. levianum (Leme 2777). E. H. wurdackii (Leme 2567). F. H. pendulum (Leme 1979). G. H. wurdackii (Leme 2567). H. H. aff. myrmecophilum (Leme 2553). I. H. pendulum (Leme 1979). J. H. eleutheropetalum (Leme 4491). K. H. levianum (Leme 5639-A) highlighting the immature seeds connected to the placenta. L–P. Neoregelia subg. Neoregelia. L–M. N. binotii (Leme 3482). N. N. ampullacea (Leme 9299). O–P. N. pontualii (Leme 5520). Q–S. Neoregelia subg. Longipetalopsis. Q–R. N. rubrovittata (Leme 1865). S. N. pernambucana (Leme 4407). Bars = 10 mm (A–F, L–S), 5 mm (G–K).

opennotspecifiedMay 2021View details →

FIGURE. Seeds of genera and subgenera of Bromelioideae. A–C. Bromelia aff. reversacantha (Leme 4609). A. Longitudinal section of the fruits with seeds connected to placenta by the funicular appendage. B. Seeds with the funicular appendage manually detached. C. Frontal view of the distal funicular pole of the seeds with the funicular appendage backwardly inrolled to the seeds and attached under an aril-like coat. D. Disteganthus lateralis (Leme 9390). E. Aechmea of the "Streptocalycoid complex": A. nidularioides (Leme 2150). F. Aechmea subg. Chevaliera s.l.: A. digitata (Leme 4019). G. Araeococcus subg. Araeococcus: A. flagellifolius (Leme 9501). H. Pseudaraeococcus lageniformis (Leme 9603). I. Cryptanthus pickelii (Leme 3873). J. Fernseea bocainensis (Leme 1422). K. Greigia stenolepis (Leme 9738). L. Neoglaziovia variegata (Leme 9631). M. Aechmea subg. Chevaliera s.l.: A. ornata (Leme 6760). N. Billbergia subg. Billbergia: B. amoena var. stolonifera (Leme 215-B). O. Billbergia subg. Helicodea: B. zebrina (Leme 128). P. Quesnelia subg. Quesnelia: Q. quesneliana (Leme 107). Q. Portea petropolitana var. noetiigii (Leme 5277). R. Billbergia subg. Billbergia: B. tweedieana (Leme 278). S. Quesnelia subg. Billbergiopsis: Q. liboniana (Leme 2361). T. Wittmackia lingulatoides (Leme 9585). Bars = 1 mm. in Re-evaluation of the Amazonian Hylaeaicum (Bromeliaceae: Bromelioideae) based on neglected morphological traits and molecular evidence

FIGURE. Seeds of genera and subgenera of Bromelioideae. A–C. Bromelia aff. reversacantha (Leme 4609). A. Longitudinal section of the fruits with seeds connected to placenta by the funicular appendage. B. Seeds with the funicular appendage manually detached. C. Frontal view of the distal funicular pole of the seeds with the funicular appendage backwardly inrolled to the seeds and attached under an aril-like coat. D. Disteganthus lateralis (Leme 9390). E. Aechmea of the "Streptocalycoid complex": A. nidularioides (Leme 2150). F. Aechmea subg. Chevaliera s.l.: A. digitata (Leme 4019). G. Araeococcus subg. Araeococcus: A. flagellifolius (Leme 9501). H. Pseudaraeococcus lageniformis (Leme 9603). I. Cryptanthus pickelii (Leme 3873). J. Fernseea bocainensis (Leme 1422). K. Greigia stenolepis (Leme 9738). L. Neoglaziovia variegata (Leme 9631). M. Aechmea subg. Chevaliera s.l.: A. ornata (Leme 6760). N. Billbergia subg. Billbergia: B. amoena var. stolonifera (Leme 215-B). O. Billbergia subg. Helicodea: B. zebrina (Leme 128). P. Quesnelia subg. Quesnelia: Q. quesneliana (Leme 107). Q. Portea petropolitana var. noetiigii (Leme 5277). R. Billbergia subg. Billbergia: B. tweedieana (Leme 278). S. Quesnelia subg. Billbergiopsis: Q. liboniana (Leme 2361). T. Wittmackia lingulatoides (Leme 9585). Bars = 1 mm.