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2,015 results for “Pneumonia”
Raw Data for the article: Klebsiella pneumoniae Lipopolysaccharides Serotype O2afg Induce Poor Inflammatory Immune Responses Ex Vivo
<p>Currently, <em>Klebsiella pneumoniae</em> is a pathogen of clinical relevance due to its plastic ability of acquiring resistance genes to multiple antibiotics. During <em>K. pneumoniae</em> infections, lipopolysaccharides (LPS) play an ambiguous role as they both activate immune responses but can also play a role in immune evasion. The LPS O2a and LPS O2afg serotypes are prevalent in most multidrug resistant <em>K. pneumoniae</em> strains. Thus, we sought to understand if those two particular LPS serotypes were involved in a mechanism of immune evasion. We have extracted LPS (serotypes O1, O2a and O2afg) from <em>K. pneumoniae</em> strains and, using human monocytes ex vivo, we assessed the ability of those LPS antigens to induce the production of pro-inflammatory cytokines and chemokines. We observed that, when human monocytes are incubated with LPS serotypes O1, O2a or O2afg strains, O2afg and, to a lesser extent, O2a but not O1 failed to elicit the production of pro-inflammatory cytokines and chemokines, which suggests a role in immune evasion. Our preliminary data also shows that nuclear translocation of NF-κB, a process which regulates an immune response against infections, occurs in monocytes incubated with LPS O1 and, to a smaller extent, with LPS O2a, but not with the LPS serotype O2afg. Our results indicate that multidrug resistant <em>K. pneumoniae</em> expressing LPS O2afg serotypes avoid an initial inflammatory immune response and, consequently, are able to systematically spread inside the host unharmed, which results in the several pathologies associated with this bacterium.</p>
Direct prediction for carbapenemase-producing and colistin-resistant Klebsiella pneumoniae isolates from routine MALDI-TOF mass spectrum using machine learning
<p>The emergence of carbapenem-nonsusceptible K. pneumoniae (CnSKP) leads a serious threat to patient survival and colistin resistance makes the treatment of CnSKP more difficultly. To make treatment strategy properly and quickly, we aimed to develop a rapid prediction method for CnSKP and colistin-resistant K. pneumoniae (ColRKP) based on the spectra of routine matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI–TOF MS). The machine learning (ML) model for differentiating CnSKP and carbapenem-susceptible K. pneumoniae (CSKP) showed accuracy of 0.8869 and AUC of 0.9551; the model for ColRKP and colistin-intermediate K. pneumoniae (ColIKP) showed accuracy of 0.8361 and the AUC of 0.8447.</p>
Klebsiella pneumoniae Centrifuge DB
<p>Plascope DB for Klebsiella pneumoniae</p>
Natural history of a bighorn sheep pneumonia epizootic
<p>A respiratory disease epizootic at the National Bison Range (NBR) in Montana in 2016-2017 caused an 85% decline in the bighorn sheep population, documented by observations of its unmarked but individually identifiable members, the subjects of an ongoing long-term study. The index case was likely one of a small group of young bighorn sheep on a short-term exploratory foray in early summer of 2016. Disease subsequently spread through the population, with peak mortality in September and October and continuing signs of respiratory disease and sporadic mortality of all age classes through early July 2017. Body condition scores and clinical signs suggested that the disease affected ewe groups before rams, although by the end of the epizootic ram mortality (90% of 71) exceeded ewe mortality (79% of 84). Microbiological sampling 10 years to 3 months prior to the epizootic had documented no evidence of infection or exposure to <i>Mycoplasma ovipneumoniae </i>at NBR, but during the epizootic a single genetic strain of <i>Mycoplasma ovipneumoniae </i>was detected in affected animals. Retrospective screening of domestic sheep flocks near the NBR identified the same genetic strain in one flock, presumptively the source of the epizootic infection. Evidence of fatal lamb pneumonia was observed during the first two lambing seasons following the epizootic but was absent during the third season following the death of the last identified <i>M. ovipneumoniae </i>carrier ewe. Monitoring of life history traits prior to the epizootic provided no evidence that environmentally and/or demographically induced nutritional or other stress contributed to the epizootic. Furthermore, the epizootic occurred despite proactive management actions undertaken to reduce risk of disease and increase resilience in this population. This closely observed bighorn sheep epizootic uniquely illustrates the natural history of the disease including the (presumptive) source of spillover, course, severity, and eventual pathogen clearance.</p>
Figure 1 in Colonization by Streptococcus pneumoniae among children in Porto Velho, Rondônia, Western Brazilian Amazon
Figure 1. Location of the study area.
DivIVA controls the dynamics of septum splitting and cell elongation in Streptococcus pneumoniae
<ul> <li>Raw phase contrast and fluorescence images to analyze the localization of DivIVA-HT in <em>Streptococcus pneumoniae</em>.</li> <li>Raw phase contrast and fluorescence images to analyze the localization of GFP-aPBP1a in <em>Streptococcus pneumoniae </em>wild-type and D<em>divIVA</em> cells.<em><br></em></li> <li>Raw phase contrast and fluorescence images to analyze the localization of GFP-aPBP2a in <em>Streptococcus pneumoniae </em>wild-type and D<em>divIVA</em> cells.</li> <li>Raw bright field (BF), diffraction-limited (DL) and reconstructed dSTORM images to analyze peptidoglycan synthesis in <em>S. pneumoniae </em>wild-type and mutant cells (D<em>divIVA</em>, D<em>pbp1a, </em>D<em>pbp2a, </em>D<em>pbp2b mltG(Y488D)</em>.</li> </ul>
Nasopharyngeal Carriage, Antimicrobial Resistance, and Serotype Distribution of Streptococcus pneumoniae in Children Under Five in Lebanon: Baseline Data Prior to PCV13 Introduction
<p>Dataset and R Code Script</p>
Indirect effect of 7-valent and 13-valent pneumococcal conjugated vaccines on pneumococcal pneumonia hospitalizations in elderly
<p>Data base and data dictionary used in the study of indirect effect of 7-valent and 13-valent pneumococcal conjugated vaccines on pneumococcal pneumonia hospitalizations in elderly</p>
Klebsiella pneumonia in Sudan: Multidrug Resistance, Poly-clonal Dissemination and Virulence
<p>Minimum spanning tree (MST) of 84 <em>K. pneumoniae</em> by hospital information. Ridom SeqSphere+ MST for 84 samples based on 2358 columns, pairwise ignoring missing values, logarithmic scale. Cluster distance threshold: 15. Isolates grouped by colour indicating the different hospitals . Samples were collected from five different hospitals, 37 different STs were identified, in addition to 14 transmission clusters, represented by shaded nodes and arrows. Numbers between the nodes indicate the number of allelic differences.</p>
Data from: Population connectivity patterns of genetic diversity, immune responses and exposure to infectious pneumonia in a metapopulation of desert bighorn sheep
<p>Habitat fragmentation is an important driver of biodiversity loss and can be remediated through management actions aimed at maintenance of natural connectivity in metapopulations. Connectivity may protect populations from infectious diseases by preserving immunogenetic diversity and disease resistance. However, connectivity could exacerbate the risk of infectious disease spread across vulnerable populations.</p> <p>We tracked the spread of a novel strain of <em>Mycoplasma ovipneumoniae</em> in a metapopulation of desert bighorn sheep (<em>Ovis canadensis nelsoni</em>) in the Mojave desert to investigate how variation in connectivity among populations influenced disease outcomes.</p> <p><em>M. ovipneumoniae</em> was detected throughout the metapopulation, indicating that the relative isolation of many of these populations did not protect them from pathogen invasion. However, we show that connectivity among bighorn sheep populations was correlated with higher immunogenetic diversity, a protective immune response and lower disease prevalence. Variation in protective immunity predicted infection risk in individual bighorn sheep and was associated with heterozygosity at genetic loci linked to adaptive and innate immune signalling.</p> <p>Together, these findings may indicate that population connectivity maintains immunogenetic diversity in bighorn sheep populations in this system and has direct effects on immune responses in individual bighorn sheep and their susceptibility to infection by a deadly pathogen.</p> <p>Our study suggests that the genetic benefits of population connectivity could outweigh the risk of infectious disease spread and supports conservation management that maintains natural connectivity in metapopulations.</p>
dSTORM imaging of Streptococcus pneumoniae using fluorescent d-amino acids
<p>Please see more details in the readme file.</p>
Genome assemblies: Horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae ST23/KL57 to Serratia marcescens
<p>Hypervirulent Klebsiella pneumonia isolates express a range of virulence factors, often encoded on virulence plasmids. Occasionally these hypervirulent lineages acquire antimicrobial resistance genes rendering them multidrug-resistant. We describe the nosocomial transmission of a hypervirulent K. pneumoniae ST23/KL57 isolate carrying an NDM-1 and OXA-48 beta-lactamase among COVID-19 patients in a Danish university hospital. Furthermore, we characterize the plasmid structure and describe a within-patient horizontal transfer of a plasmid carrying a blaOXA-48 gene from K. pneumoniae ST23/KL57 to a Serratia marcescens isolate.</p>
Epithelial Micro-Invasion Events by Streptococcus pneumoniae Drives Unique Epithelial Cell Responses
<p>RNA Sequencing dataset for Weight et al Manuscript.</p>
Ceftriaxone to PRevent pneumOnia and inflammatTion aftEr Cardiac arresT (PROTECT)
ClinicalTrials.gov study NCT04999592. IPD Sharing: NO. Countries: 1. Publications: 2.
Study of Progression of Community Acquired Pneumonia in the Hospital
ClinicalTrials.gov study NCT02782013. IPD Sharing: YES. Countries: 2. Publications: 3.
Bacterial Pneumonia Score (BPS) Guided Antibiotic Use in Children With Pneumonia and Pneumococcal Vaccine
ClinicalTrials.gov study NCT01875731. IPD Sharing: NO. Countries: 1. Publications: 2.
Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)
ClinicalTrials.gov study NCT04870125. IPD Sharing: YES. Countries: 1. Publications: 12.
Comparative Study of Ceftaroline vs. Ceftriaxone in Adults With Community-Acquired Pneumonia
ClinicalTrials.gov study NCT00509106. IPD Sharing: Not stated. Countries: 15. Publications: 7.
Improving Oral Care to Reduce Hospital-Acquired Pneumonia (HAP) in the Acute Neurologically Impaired Adult
ClinicalTrials.gov study NCT01498601. IPD Sharing: Not stated. Countries: 1. Publications: 21.
Inhaled Amikacin Solution BAY41-6551 as Adjunctive Therapy in the Treatment of Gram-Negative Pneumonia
ClinicalTrials.gov study NCT01799993. IPD Sharing: Not stated. Countries: 12. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.