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64 results for “Preclinical studies”
Data from: Non-industry sponsored preclinical studies on statins yield greater efficacy estimates than industry-sponsored studies: a meta-analysis
Industry-sponsored clinical drug studies are associated with publication of outcomes that favor the sponsor, even when controlling for potential bias in the methods used. However, the influence of sponsorship bias has not been examined in preclinical animal studies. We performed a meta-analysis of preclinical statin studies to determine whether industry sponsorship is associated with either increased effect sizes of efficacy outcomes and / or risks of bias in a cohort of published preclinical statin studies. We searched Medline (January 1966 - April 2012) and identified 63 studies evaluating the effects of statins on atherosclerosis outcomes in animals. Two coders independently extracted study design criteria aimed at reducing bias, results for all relevant outcomes, sponsorship source, and investigator financial ties. The I2 statistic was used to examine heterogeneity. We calculated the standardized mean difference (SMD) for each outcome and pooled data across studies to estimate the pooled average SMD using random effects models. In a priori subgroup analyses, we assessed statin efficacy by outcome measured, sponsorship source, presence or absence of financial conflict information, use of an optimal time window for outcome assessment, accounting for all animals, inclusion criteria, blinding, and randomization. The effect of statins was significantly larger for studies sponsored by non-industry sources (-1.99; 95% CI -2.68, -1.31) versus studies sponsored by industry (-0.73; 95% CI -1.00, -0.47) (p value < 0.001). Statin efficacy did not differ by disclosure of financial conflict information, use of an optimal time window for outcome assessment, accounting for all animals, inclusion criteria, blinding, and randomization. Possible reasons for the differences between non-industry and industry sponsored studies, such as selective reporting of outcomes, require further study.
Tau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers in the Treatment of Autosoma
ClinicalTrials.gov study NCT03977584. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: The relationship between risk of bias criteria, research outcomes, and study sponsorship in a cohort of preclinical thiazolidinedione animal studies: a meta-analysis
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Data from: Non-industry sponsored preclinical studies on statins yield greater efficacy estimates than industry-sponsored studies: a meta-analysis
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CSF synaptic biomarkers in the preclinical stage of Alzheimer’s disease and their association with MRI and PET markers of neurodegeneration: a cross-sectional study
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An in vivo avian paradigm to model human melanoma disease and perform fast and relevant preclinical studies
GEO Series GSE206689. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies
GEO Series GSE263274. Mus musculus. 45 samples. Type: Expression profiling by high throughput sequencing.
Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole.
GEO Series GSE82161. Homo sapiens. 4 samples. Type: Expression profiling by array.
A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies (RNA-Seq)
GEO Series GSE145557. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers.
GEO Series GSE172218. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
The mRNA-LNP platform’s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory
GEO Series GSE167521. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies (WES)
GEO Series GSE145558. Mus musculus. 9 samples. Type: Other.
Comparative analysis of gene expression in tumors responding and non-responding to anti-CTLA-4 in a preclinical study of melanoma
GEO Series GSE255484. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing.
Age-dependent differences in the tumor microenvironment of preclinical models of triple-negative breast cancer: challenges and opportunities for efficacy studies.
GEO Series GSE252968. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
ATI-1777 a topical JAK1/3 inhibitor may benefit atopic dermatitis without systemic drug exposure, results from preclinical development and Phase 2a randomized-control study ATI-1777-AD-201
GEO Series GSE244201. Sus scrofa. 8 samples. Type: Expression profiling by high throughput sequencing.
HSP90 specific nIR probe identifies aggressive prostate cancers: a translational study from preclinical models to a human pilot study
GEO Series GSE164865. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical Study
ClinicalTrials.gov study NCT04288635. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease
ClinicalTrials.gov study NCT06544616. IPD Sharing: YES. Countries: 9. Publications: 0.
Cell Culture of Glioma Specimens for in Vitro Preclinical Studies
ClinicalTrials.gov study NCT01125826. IPD Sharing: Not stated. Countries: 1. Publications: 0.
"Constitution of a Biological Collection to Establish Preclinical Translational Models for the Study of Tumors and Chronic Liver Diseases".
ClinicalTrials.gov study NCT04690972. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.