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84 results for “Pyrimidines”
Figure 2 from: Vlasov SV, Borysov OV, Severina HI, Vlasov VS, Abu Sharkh AIM, Georgiyants VA (2024) Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e110013
Figure 2 Design strategy for target thieno[2,3-d]pyrimidines with benzyl amides fragment as antimicrobial activity.
Figure 4 from: Vlasov SV, Borysov OV, Severina HI, Vlasov VS, Abu Sharkh AIM, Georgiyants VA (2024) Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e110013
Figure 4 3D visualization of the compatible conformation the ligand 5.5 (blue molecule) and the reference inhibitor (yellow molecule) (Zhong et al. 2019) in the active site of TrmD P. aeruginosa.
Figure 1 from: Vlasov SV, Borysov OV, Severina HI, Vlasov VS, Abu Sharkh AIM, Georgiyants VA (2024) Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e110013
Figure 1 The derivatives of thieno[2,3-d]pyrimidine-6-carboxylic acids with antimicrobial properties.
Figure 3 from: Vlasov SV, Borysov OV, Severina HI, Vlasov VS, Abu Sharkh AIM, Georgiyants VA (2024) Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e110013
Figure 3 3D visualization of the interaction of ligand 5.5 with the amino acid residues of the active site of the TrmD inhibitor of TrmD P. aeruginosa.
Fig. 2 in Floro-pyrazolo[3,4-d]pyrimidine derivative as a novel plant activator induces two-pathway immune system
Fig. 2. The synthetic route of targeted compounds.
Fig. 1 in Floro-pyrazolo[3,4-d]pyrimidine derivative as a novel plant activator induces two-pathway immune system
Fig. 1. Overview of scaffold and derivatives design.
Fig. 3 in Floro-pyrazolo[3,4-d]pyrimidine derivative as a novel plant activator induces two-pathway immune system
Fig. 3. Design of target compounds.
Comparative analysis between single-cell RNA-seq and single-molecule RNA FISH indicates that the pyrimidine nucleobase idoxuridine (IdU) globally amplifies transcriptional noise
GEO Series GSE263194. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity [HeLa_CAD_RNA-seq]
GEO Series GSE161733. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
The mevalonate pathway is required for pyrimidine synthesis and survival of p53-deficient colon cancer cells in metabolically compromised environments
GEO Series GSE124189. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
ASH1L guards cis-regulatory elements against cyclobutane pyrimidine dimer induction
GEO Series GSE260917. Homo sapiens. 11 samples. Type: Other.
TMPRSS2-ERG and gain-of-function p53 mutants co-dictate pyrimidine synthesis and prostate cancer fitness [ERG and p53 ChIP-seq]
GEO Series GSE184623. Homo sapiens. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models
GEO Series GSE262721. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of pyrimidine biosynthesis targets protein translation in AML [RNA-seq_MN]
GEO Series GSE181661. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity [WT_vs_Yme1lKO_MEF_RNA-seq]
GEO Series GSE161735. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of pyrimidine biosynthesis targets protein translation in AML [Targeted_CRISPR_screen]
GEO Series GSE181665. Mus musculus. 7 samples. Type: Other.
Inhibition of pyrimidine biosynthesis targets protein translation in AML [RNA-seq_I1DN]
GEO Series GSE181663. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T-cell development [SCRB-seq]
GEO Series GSE200359. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T-cell development [scRNA-Seq 10x]
GEO Series GSE200488. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Metabolic Dependency on De Novo Pyrimidine Synthesis in Platinum Resistant Ovarian Cancer
GEO Series GSE283381. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.