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333 results for “Salivary glands”
Nivolumab plus ipilimumab in advanced salivary gland cancer: a phase 2 trial
<p>This is a de-identified dataset accompanying the <em>Nature Medicine</em> publication titled "<strong>Nivolumab plus ipilimumab in advanced salivary gland cancer: a phase 2 trial</strong>", by Vos <em>et al. </em>(DOI: https://doi.org/10.1038/s41591-023-02518-x). It contains the clinical features and processed data of 64 patients with salivary gland cancer, treated with nivolumab and ipilimumab immunotherapy. These data underlie results reported in the article. Raw whole-exome and RNA sequencing data generated in this study have been made publicly available at SRA under BioProject number PRJNA940989.</p>
TGF-β3 increases the severity of radiation-induced oral mucositis and salivary gland fibrosis in a mouse model
<p>This is a collection of results from a preclinical trial investigating the effects of TGF-B3 treatment on healthy tissue radiotoxicity in C57BL/6 mice after fractionated head and neck radiotherapy. Survival, body weight, oral mucositis, lip dermatitis, saliva volume, and salivary gland collagen deposition were monitored. This data set is used in the manuscript "TGF-β3 increases the severity of radiation-induced oral mucositis and salivary gland fibrosis in a mouse model". </p> <p> </p>
Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery
ClinicalTrials.gov study NCT02538510. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Nivolumab and Ipilimumab in Treating Patients With Metastatic/Recurrent ACC of All Sites and Non-ACC Salivary Gland Cancer
ClinicalTrials.gov study NCT03146650. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of Nivolumab Plus Ipilimumab in Patients With Salivary Gland Cancer
ClinicalTrials.gov study NCT03172624. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer
ClinicalTrials.gov study NCT00068237. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Iressa Study in Patients With Salivary Gland Cancer
ClinicalTrials.gov study NCT00509002. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland Cancers
ClinicalTrials.gov study NCT04209660. IPD Sharing: YES. Countries: 1. Publications: 1.
Data for PNASnexus article Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype
Open the record for dataset details and reuse information.
Data from: Salivary gland ultrasonography as a predictor of clinical activity in Sjögren's syndrome
Purpose: Primary Sjögren's syndrome is a multisystem autoimmune disease characterized by hypofunction of salivary and lacrimal glands and possible multi-organ system manifestations. Over the past 15 years, three sets of diagnostic criteria have been proposed, but none has included salivary gland ultrasonography. However, recent studies support its role in the diagnosis and prognostic evaluation of patients with Sjögren's syndrome. This study aimed to determine the value of salivary gland ultrasonography in the diagnosis and prognosis of Sjögren's syndrome by relating ultrasonography severity scores to clinical and laboratory data. Methods: Seventy patients who fulfilled the 2002 American-European Consensus Group diagnostic criteria for primary Sjögren's syndrome were selected from 84 patients receiving care in specialized outpatient clinics at our institution from November 2013 to May 2016. Their serology, European League Against Rheumatism Sjögren's syndrome disease activity index (ESSDAI), salivary flow rate, immunoglobulin G, and salivary and serum beta-2 microglobulin levels were measured. Salivary gland ultrasonography was performed by an experienced radiologist, using scores of 1-4 to classify salivary gland impairment. Results: Salivary gland ultrasonography scores of 1 or 2 were associated with an ESSDAI < 5. Ultrasonography scores of 3 or 4 were associated with an ESSDAI ≥ 5 (p=0.064), a positive antinuclear antibody test (p=0.006), positive anti-Ro/SSA antibodies (p=0.003), positive anti-La/SSB antibodies (p=0.077), positive rheumatoid factor (p=0.034), and immunoglobulin G levels > 1600 mg/dL (p=0.077). Salivary flow rate was lower in patients with scores 3 or 4 (p=0.001). Conclusion: This study provides further evidence that salivary gland ultrasonography can be used not only for diagnosis but also for prognostic evaluation of primary Sjögren's syndrome. These findings confirm what has been reported in the literature. However, further analyses involving larger matched samples are required to support this finding and include salivary gland ultrasonography as part of the diagnostic criteria for Sjögren's syndrome.
Replication Data for: OPTICAL COHERENCE TOMOGRAPHY IDENTIFIES LOWER LABIAL SALIVARY GLAND SURFACE DENSITY IN CYSTIC FIBROSIS
<p>Swept-source optical coherence tomography images of the mucosa of the lower lip acquired in 18 cystic fibrosis patients (CF.zip, includes an XLS file with additional data) and 18 healthy volunteers (HS.zip). Within the volumetric datasets consisting of sets of images the labial salivary glands can be identified.</p> <p>Authors: Nowak JK, Grulkowski I, Karnowski K, Wojtkowski M, Walkowiak J.<br /> When using the data, please always refer to the original paper (currently under review in PLOS ONE; title as specified above).</p> <p>The methodology used to obtain the volumetric datasets is described in:<br /> Grulkowski I, Nowak JK, Karnowski K, Zebryk P, Puszczewicz M, Walkowiak J, Wojtkowski M. Quantitative assessment of oral mucosa and labial minor salivary glands in patients with Sjögren’s syndrome using swept source OCT. Biomedical Optics Express, Vol. 5, Issue 1, pp. 259-274 (2014). DOI: http://dx.doi.org/10.1364/BOE.5.000259</p>
FIGURE 3. Salivary gland chromosome arms B and F. a in Chironomus polonicus sp. n. (Diptera: Chironomidae) from southern Poland
FIGURE 3. Salivary gland chromosome arms B and F. a: chromosome BF of Chironomus polonicus sp. n. [band patterns of arm F can compare with the same arm of C. aprilinus (b)]; b: chromosome arm F of Chironoimus aprilinus Kieffer [according to Keyl (1962)]. The arrow indicates the localization of the centromere. Bar = 100 μm.
FIGURE 2. Salivary gland chromosome arms A and E. a in Chironomus polonicus sp. n. (Diptera: Chironomidae) from southern Poland
FIGURE 2. Salivary gland chromosome arms A and E. a: Chromosome arm A of Chironomus piger Strenzke (according to Keyl, 1962); b: Chromosome arm A of Chironomus pseudothummi Strenzke (according to Keyl, 1962); c: Chromosome AE of Chironomus polonicus sp. n. [band patterns of arm A can compare with the same arm of C. piger (a) and C. pseudothummi (b); band patterns of arm E can compare with the same arm of C. pseudothummi (d)]; d: Chromosome arm of Chironomus pseudothummi Strenzke [according to Keyl (1962)]. The arrow indicates the localization of the centromere. Bar = 100 μm.
FIGURE 4. Salivary gland chromosome arms C, D and G. a in Chironomus polonicus sp. n. (Diptera: Chironomidae) from southern Poland
FIGURE 4. Salivary gland chromosome arms C, D and G. a: chromosome CD of C. polonicus sp. n; b: chromosome G of C. polonicus sp. n. BR—Balbiani Ring, NOR—Nucleolar organizer. The arrow indicates the position of the centromere. Bar = 100 μm.
The salivary gland transcriptome of Varroa destructor reveals suitable targets for RNAi-based mite control
<p><span>The mite <em>Varroa destructor</em> has a dramatic impact on beekeeping, and is one of the main causes of honey bee colony losses. This ectoparasite feeds on honey bees’ liquid tissues through a wound created on the host integument, which determines weight loss, a reduced lifespan and the transmission of viral pathogens. However, despite its importance, the mite feeding strategy and the host regulation role by the salivary secretions have been poorly explored. Here we contribute to fill this gap by identifying the salivary components of <em>V. destructor </em>and by studying their on mite feeding and survival. Our differential expression analysis identified 30 salivary gland genes encoding putatively secreted proteins, among which only 15 were found to be functionally annotated. These latter include proteins with putative antibacterial, antifungal, cytolytic, digestive and immunosuppressive function. To study the role of the identified genes on mite feeding we selected the three most highly transcribed genes coding for: a chitin-binding domain protein (CHIBIN), a Kazal domain serine protease inhibitor (KAZAL) and a papain-like cysteine protease (PAPA). Knockdown of CHIBIN was associated with a significant decrease of mite survival, likely interfering with the immune reaction to facilitate mite feeding. This work expands our knowledge of the host regulation and nutritional exploitation strategies adopted by ectoparasites of arthropods and allows the identification of novel targets for RNAi-based strategies <span> </span>of <em>Varroa </em>mite control. <span> </span></span></p>
Nivolumab in Recurrent or Metastatic Salivary Gland Carcinoma of the Head and Neck
ClinicalTrials.gov study NCT03132038. IPD Sharing: NO. Countries: 1. Publications: 1.
Imatinib Mesylate in Treating Patients With Salivary Gland Cancer
ClinicalTrials.gov study NCT00045669. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Evaluation of Salivary Gland Dysfunction
ClinicalTrials.gov study NCT00001196. IPD Sharing: Not stated. Countries: 1. Publications: 6.
A Stimulator of the Salivary Vibration of the Parotid Glands
ClinicalTrials.gov study NCT05129111. IPD Sharing: NO. Countries: 1. Publications: 2.
Postoperative Concurrent Chemoradiotherapy in Treating Patients With High-Risk Salivary Gland Carcinomas
ClinicalTrials.gov study NCT02776163. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.