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84 results for “Schistosoma mansoni”
Repeated Controlled Human Schistosoma Mansoni Infection
ClinicalTrials.gov study NCT05085470. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Trial to Investigate the Effect of Schistosoma Mansoni Infection on the Response to Vaccination With MVA85A in BCG-vaccinated African Adolescents
ClinicalTrials.gov study NCT02178748. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Data from: Inbreeding within human Schistosoma mansoni: do host- specific factors shape the genetic composition of parasite populations?
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Schistosoma mansoni raw genotype calls from exome data
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Data from: Contrasting the distribution of phenotypic and molecular variation in the freshwater snail Biomphalaria pfeifferi, the intermediate host of Schistosoma mansoni
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Comparative Proteomics Reveals Characteristic Proteins on Praziquantel-resistance in Schistosoma mansoni
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Schistosoma mansoni IgG antibody response and Kato-Katz infection among pre-school aged children in Mbita, Western Kenya 2012-2014
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Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni
<p><span><span><span><span><span><span><span><span><span><span><span>Schistosomes kill 250,000 people every year. Treatment of schistosomiasis relies on a single drug (praziquantel). Unfortunately, a scarcity of molecular tools has hindered the discovery of new drug targets. Here, we describe a large-scale RNA interference screen in adult Schistosoma mansoni examining the function of 2,216 genes. We discovered 250 genes with phenotypes affecting neuromuscular function, tissue integrity, stem cell maintenance, and parasite survival. Leveraging these data, we prioritize compounds with activity against the parasites and uncover a pair of protein kinases (TAO and STK25) that cooperate to maintain muscle-specific mRNA transcription. Loss of either of these kinases results in paralysis and worm death in a mammalian host. These studies will expedite therapeutic development and invigorate studies of these neglected parasites. Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni.</span></span></span></span></span></span></span></span></span></span></span></p> <p> </p>
A single-cell RNAseq atlas of Schistosoma mansoni identifies a key regulator of blood feeding
<p>Schistosomiasis is a neglected tropical disease that infects 240 million people. With no vaccines and only one drug available, new therapeutic targets are needed. The causative agents, schistosomes, are intravascular flatworm parasites that feed on blood and lay eggs, causing pathology. The function of the parasite's various tissues in successful parasitism are poorly understood, hindering identification of novel therapeutic targets. Using single cell RNAseq we characterize 43,642 cells from the adult schistosome, identifying 68 distinct cell populations including specialized stem cells that maintain the parasite's blood-digesting gut. These stem cells express the gene hnf4, which is required for gut maintenance, blood feeding, and pathology in vivo. Together, these data provide molecular insights into the organ systems of this important pathogen and identify potential therapeutic targets.</p>
Figure 1 from: Acquah ME, Aboagye F, Ashong Y, Mosi L (2024) Development of a field diagnostic tool for Schistosoma mansoni Praziquantel resistant markers in selected endemic communities. Research Ideas and Outcomes 10: e120899. https://doi.org/10.3897/rio.10.e120899
Figure 1 Graphical Abstract. Adapted from Summers et al. (2022), available under the terms of the Creative Commons Attribution License 4.0 (CC BY 4.0).
A single-cell RNAseq atlas of Schistosoma mansoni identifies a key regulator of blood feeding
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Data from: Vertebrate host protective immunity drives genetic diversity and antigenic polymorphism in Schistosoma mansoni
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Data from: The effects of sub-curative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni
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Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni
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Transcriptional analysis of Schistosoma mansoni treated with sub-lethal doses of the anthelmintic drug praziquantel
GEO Series GSE29535. Schistosoma mansoni. 42 samples. Type: Expression profiling by array.
A single-cell RNA-seq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding [RNA-Seq]
GEO Series GSE146735. Schistosoma mansoni. 6 samples. Type: Expression profiling by high throughput sequencing.
Combinatory microarray and SuperSAGE analyses identify pairing-dependently transcribed genes in Schistosoma mansoni males, including follistatin [SuperSAGE]
GEO Series GSE45628. Schistosoma mansoni. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-cell analysis reveals regulation of germline stem cell fate in the human parasite Schistosoma mansoni
GEO Series GSE147355. Schistosoma mansoni. 29 samples. Type: Expression profiling by high throughput sequencing.
Sm29 is a protective surface protein from the tegument of lung-stage Schistosoma mansoni
GEO Series GSE10777. Schistosoma mansoni. 8 samples. Type: Expression profiling by array.
Temporal modulation of gene expression in a controlled Schistosoma mansoni human infection model
GEO Series GSE313156. Homo sapiens. 144 samples. Type: Expression profiling by high throughput sequencing.
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