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245 results for “Streptococcus pneumoniae”
Antibiotic tolerance indicative for persistence is pervasive among clinical Streptococcus pneumoniae isolates and shows strong condition dependence - dataset
<p>The dataset is linked to the article entitled 'Antibiotic tolerance indicative for persistence is pervasive among clinical <em>Streptococcus pneumoniae</em> isolates and shows strong condition dependence' with following abstract. </p> <p><em>Streptococcus pneumoniae</em> is an important human pathogen, being one of the most common causes of community-acquired pneumonia and otitis media. Antibiotic resistance in <em>S. pneumoniae</em> is an emerging problem as it depletes our arsenal of effective drugs. In addition, persistence also contributes to the antibiotic crisis in many other pathogens, yet, in <em>S. pneumonia</em>e little is known about antibiotic-tolerant persisters and robust experimental means are lacking. Persister cells are phenotypic variants that exist as a subpopulation within a clonal culture. Being tolerant to lethal antibiotics, they underly the chronic nature of a variety of infections and even help in acquiring genetic resistance. Here, we set out to identify and characterize persistence in <em>S. pneumoniae. </em>Specifically, we followed different strategies to overcome the self-limiting nature of<em> S. pneumoniae </em>as confounding factor in the prolonged monitoring of antibiotic survival needed to study persistence. In optimized conditions, we identified genuine persisters in various growth phases and for four relevant antibiotics through biphasic survival dynamics and heritability assays. Finally, we detected a high variety in antibiotic survival levels across a diverse collection of <em>S. pneumoniae</em> clinical isolates, which assumes that a high natural diversity in persistence is widely present in <em>S. pneumoniae</em>. Collectively, this proof-of-concept significantly progresses the understanding of the importance of antibiotic persistence in<em> S. pneumoniae</em> infections which will set stage for characterizing its relevance to clinical outcomes and advocates for increased attention to the phenotype in both fundamental and clinical research.</p>
Streptococcus Pneumonia: Effects of PCV13 on Pneumococcal Carriage
ClinicalTrials.gov study NCT01109108. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immunity to Serotype 19A Streptococcus Pneumoniae in Children Vaccinated With PCV10
ClinicalTrials.gov study NCT04912297. IPD Sharing: NO. Countries: 1. Publications: 0.
Prevalence of Nasopharyngeal Carriage of Streptococcus Pneumoniae in Healthy Children of 12-18 Months in 6 Cities, China
ClinicalTrials.gov study NCT00952367. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Nasopharyngeal Streptococcus Pneumoniae Carriage
ClinicalTrials.gov study NCT00471822. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Epidemiology and Household Transmission of Streptococcus Pneumoniae and Respiratory Syncytial Virus
ClinicalTrials.gov study NCT05017519. IPD Sharing: NO. Countries: 0. Publications: 40.
Data from: Competence increases survival during stress in Streptococcus pneumoniae.
Open the record for dataset details and reuse information.
Dual infection by respiratory syncytial virus and Streptococcus pneumoniae in an experimental lamb model
Open the record for dataset details and reuse information.
Impact of copY delation on the transcriptome of Streptococcus pneumoniae D39
GEO Series GSE30414. Streptococcus pneumoniae D39. 4 samples. Type: Expression profiling by array.
Changes in relative transcript amounts caused by ∆phoU2::kanrpsL+ and double ∆phoU2::kanrpsL+ ∆phoU1::Pcerm mutations in Streptococcus pneumoniae
GEO Series GSE80637. Streptococcus pneumoniae. 9 samples. Type: Expression profiling by high throughput sequencing.
Changes in relative transcript amounts caused by ∆tprA, ∆phrA, double ∆tprA ∆phrA mutation or the addition of PhrA peptide in Streptococcus pneumoniae
GEO Series GSE68598. Streptococcus pneumoniae. 15 samples. Type: Expression profiling by high throughput sequencing.
Impact of galR delation on the transcriptome of Streptococcus pneumoniae D39 in the presence of Galactose
GEO Series GSE74501. Streptococcus pneumoniae D39. 2 samples. Type: Expression profiling by array.
Impact of DFMO and AMXT 1501 on Gene Expression and Capsule Regulation in Streptococcus pneumoniae
GEO Series GSE252370. Streptococcus pneumoniae D39. 12 samples. Type: Expression profiling by high throughput sequencing.
Impact of lacT delation on the transcriptome of Streptococcus pneumoniae D39 in the presence of Lactose
GEO Series GSE58182. Streptococcus pneumoniae D39. 2 samples. Type: Expression profiling by array.
Redefining the sRNA transcriptome of Streptococcus pneumoniae serotype 2 strain D39
GEO Series GSE124170. Streptococcus pneumoniae D39. 10 samples. Type: Expression profiling by high throughput sequencing.
An in vivo atlas of host-pathogen transcriptomes during Streptococcus pneumoniae colonization and disease
GEO Series GSE150788. Mus musculus; Streptococcus pneumoniae. 44 samples. Type: Expression profiling by high throughput sequencing.
Impact of plfB delation on the transcriptome of Streptococcus pneumoniae D39
GEO Series GSE67668. Streptococcus pneumoniae D39. 2 samples. Type: Expression profiling by array.
Bulk RNAseq profiling of Streptococcus pneumoniae EF3030 and Influenza A virus (A/California/07/2009(H1N1)) mono/coinfection in the mouse lungs.
GEO Series GSE294560. Mus musculus. 60 samples. Type: Expression profiling by high throughput sequencing.
Changes in relative transcript amounts caused by heat in Streptococcus pneumoniae
GEO Series GSE103778. Streptococcus pneumoniae. 10 samples. Type: Expression profiling by high throughput sequencing.
IPTG-induced CRISPRi repression of firefly luciferase in Streptococcus pneumoniae
GEO Series GSE89763. Streptococcus pneumoniae. 6 samples. Type: Expression profiling by high throughput sequencing.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.